WIF1

Wnt inhibitory factor 1is aproteinthat in humans is encoded by theWIF1gene.WIF1 is alipid-binding protein that binds toWntproteins and prevents them from triggering signalling.

WIF1
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 2D3J,2YGN,2YGO,2YGP,2YGQ
Identifiers
Aliases	WIF1,WIF-1, WNT inhibitory factor 1
External IDs	OMIM:605186;MGI:1344332;HomoloGene:31430;GeneCards:WIF1;OMA:WIF1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q14.3 Start 65,050,626bp End 65,121,305bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 D2 Start 120,869,865bp End 120,936,555bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in lower lobe of lung periodontal fiber tibia parotid gland caudate nucleus putamen corpus epididymis tail of epididymis nucleus accumbens trabecular bone Top expressed in molar skin of external ear dermis body of femur seminal vesicula intercostal muscle trachea ankle calvaria conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Wnt-protein binding protein binding signaling receptor binding Cellular component extracellular region cell surface Biological process multicellular organism development negative regulation of Wnt signaling pathway Wnt signaling pathway signal transduction positive regulation of fat cell differentiation anatomical structure development Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 11197 24117 Ensembl ENSG00000156076 ENSMUSG00000020218 UniProt Q9Y5W5 Q9WUA1 RefSeq (mRNA) NM_007191 NM_011915 RefSeq (protein) NP_009122 NP_036045 Location (UCSC) Chr 12: 65.05 – 65.12 Mb Chr 10: 120.87 – 120.94 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Function

WNT proteins are extracellular signaling molecules involved in the control ofembryonic development.This gene encodes a secreted protein, which binds WNT proteins and inhibits their activities. This protein contains a WNT inhibitory factor (WIF) domain and 5 epidermal growth factor (EGF)-like domains. It may be involved inmesodermsegmentation. This protein is found to be present in fish, amphibia and mammals.

Further reading

• Shepelev MV, Korobko EV, Korobko IV (2006). "[WIF1: perspectives of application in oncology]".Mol. Gen. Mikrobiol. Virusol.(4): 3–7.PMID17094650.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Reguart N, He B, Xu Z, et al. (2004). "Cloning and characterization of the promoter of human Wnt inhibitory factor-1".Biochem. Biophys. Res. Commun.323(1): 229–34.doi:10.1016/j.bbrc.2004.08.075.PMID15351726.
• Esufali S, Bapat B (2004). "Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of beta-catenin and TCF/LEF-mediated transcriptional activation".Oncogene.23(50): 8260–71.doi:10.1038/sj.onc.1208007.PMID15377999.S2CID30877665.
• Ohigashi T, Mizuno R, Nakashima J, et al. (2005). "Inhibition of Wnt signaling downregulates Akt activity and induces chemosensitivity in PTEN-mutated prostate cancer cells".Prostate.62(1): 61–8.doi:10.1002/pros.20117.PMID15389810.S2CID1398615.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Simon M, Grandage VL, Linch DC, Khwaja A (2005)."Constitutive activation of the Wnt/beta-catenin signalling pathway in acute myeloid leukaemia".Oncogene.24(14): 2410–20.doi:10.1038/sj.onc.1208431.PMID15735743.
• Taniguchi H, Yamamoto H, Hirata T, et al. (2005)."Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers".Oncogene.24(53): 7946–52.doi:10.1038/sj.onc.1208910.PMID16007117.
• Lin YC, You L, Xu Z, et al. (2006). "Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines".Biochem. Biophys. Res. Commun.341(2): 635–40.doi:10.1016/j.bbrc.2005.12.220.PMID16427602.
• Urakami S, Shiina H, Enokida H, et al. (2006). "Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway".Clin. Cancer Res.12(2): 383–91.doi:10.1158/1078-0432.CCR-05-1344.PMID16428476.S2CID22202251.
• Liepinsh E, Bányai L, Patthy L, Otting G (2006). "NMR structure of the WIF domain of the human Wnt-inhibitory factor-1".J. Mol. Biol.357(3): 942–50.doi:10.1016/j.jmb.2006.01.047.PMID16476441.
• Batra S, Shi Y, Kuchenbecker KM, et al. (2006). "Wnt inhibitory factor-1, a Wnt antagonist, is silenced by promoter hypermethylation in malignant pleural mesothelioma".Biochem. Biophys. Res. Commun.342(4): 1228–32.doi:10.1016/j.bbrc.2006.02.084.PMID16516163.
• Chim CS, Chan WW, Pang A, Kwong YL (2006)."Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor".Leukemia.20(5): 907–9.doi:10.1038/sj.leu.2404176.PMID16525492.
• Urakami S, Shiina H, Enokida H, et al. (2006)."Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection".Clin. Cancer Res.12(7 Pt 1): 2109–16.doi:10.1158/1078-0432.CCR-05-2468.PMID16609023.
• Milutinovic S, D'Alessio AC, Detich N, Szyf M (2007)."Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes".Carcinogenesis.28(3): 560–71.doi:10.1093/carcin/bgl167.PMID17012225.
• Queimado L, Lopes CS, Reis AM (2007). "WIF1, an inhibitor of the Wnt pathway, is rearranged in salivary gland tumors".Genes Chromosomes Cancer.46(3): 215–25.doi:10.1002/gcc.20402.PMID17171686.S2CID34184943.
• Chan SL, Cui Y, van Hasselt A, et al. (2007)."The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas".Lab. Invest.87(7): 644–50.doi:10.1038/labinvest.3700547.PMID17384664.
• Veeck J, Wild PJ, Fuchs T, et al. (2009)."Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer".BMC Cancer.9:1–13.doi:10.1186/1471-2407-9-217.PMC2717119.PMID19570204.