Wikipedia

Wim Crusio

Wim E. Crusio(bornWilhelmus Elisabeth Crusioon 20 December 1954) is aDutchbehavioralneurogeneticistand adirecteur de recherche(research director) with theFrench National Centre for Scientific ResearchinTalence,France.

Wim E. Crusio
Wilhelmus Elisabeth Crusio
Wim Crusio, August 2006
Born(1954-12-20)20 December 1954(age 69)
Bergen op Zoom,TheNetherlands
CitizenshipDutch
Alma materRadboud University Nijmegen
Known forBehavioral neurogenetics of thehippocampus,mousemodelsofneuropsychiatric disorders
AwardsIBANGS Distinguished Service Award
Scientific career
Fieldsbehavioralandneuralgenetics,behavioral neuroscience
InstitutionsRadboud University Nijmegen,University of Heidelberg,French National Centre for Scientific Research(CNRS;Paris,Orleans,andTalence (Bordeaux)),University of Massachusetts Medical School
ThesisOlfaction and behavioral responses to novelty in mice: a quantitative-genetic analysis(1984)
Doctoral advisorHans van Abeelen
Other academic advisorsBram van Overbeeke,
Hendrik de Wit,
Victor Westhoff
Author abbrev. (botany)Crusio
Wikispecieshas information related toWim Crusio.

Education and career

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Crusio received his bachelor's degree in biology fromRadboud University Nijmegenin 1975, where he went on to obtain amaster's degreeand then aPhDin 1979 and 1984, respectively.[1]HisAnubiasrevision, which was originally published in 1979,[1]was translated in German[2]and continues to engender interest.[3]For his PhD thesis, Crusio studied the inheritance of the effects ofanosmiaonexploratory behaviorof mice, and more in general thegenetic architectureof exploratory behavior, usingquantitative-geneticmethods such as thediallel cross.[4]From 1984 to 1987, Crusio worked as apostdocat theUniversity of Heidelberg,supported by aNATOScience Fellowship[5]and anAlexander von Humboldt Research Fellowship.[6]During 1988, Crusio spent a year inParis,France,supported by a fellowship from theFyssen Foundation.[7]He then returned to Heidelberg as a senior research scientist before being recruited aschargé de rechercheby the CNRS, initially working in an institute of theUniversité René Descartes(Paris V) and later moving to the CNRScampusinOrléans,having been promoted todirecteur de recherche.[5]In 2000 he became fullprofessorofpsychiatryat theUniversity of Massachusetts Medical SchoolinWorcester, Massachusetts,returning to the CNRS in 2005 as a group leader in theCentre de Neurosciences Intégratives et CognitivesinTalence,a suburb ofBordeaux.[5][8][9]He is currently adjunct director of the Institut de Neurosciences Cognitives et Intégratives d'Aquitaine.[10]

Research

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Hippocampal mossy fibers

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Crusio and his collaborators found thatneuroanatomicalvariations in the mousehippocampus,in particular the sizes of their intra- and infrapyramidalmossy fibers(IIPMF) correlated with learning performance.[11]Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found forspatial learningin aradial arm mazetask.[12][13][14]Taken together, Crusio and collaborators think that it is highly likely that this correlation iscausal,[15]although this is not universally accepted.[16]

Mouse model of depression

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When mice are exposed to unpredictablechronicmildstress(UCMS), they start exhibiting symptoms reminiscent ofmajor depressive disorderin humans.[17]As it had been suggested that deficits in hippocampalneurogenesismight underlie depression,[18]Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels ofaggression,[19]anxiety,[20][21]depressive-like behaviors,[20]and learning,[22]with a concomitant drop in neurogenesis.[22]However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.[22]

Mouse model of autism

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More recently, Crusio has been investigating the possibility thatFmr1knockout micemight perhaps be used as amodelforautism.This idea is based on the fact that patients suffering from theFragile X syndrome,caused by a deficiency of theFMR1gene often show autisticsymptoms.A good mouse model for the Fragile X syndrome is available in the form of mice in which theFmr1gene (the mousehomologueof the humanFMR1gene) has been invalidated.[23]A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms,[24]especially changes insocial behavior,a key symptom of autism.[25][26]

Editorial activities

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Crusio is the foundingeditor-in-chiefofGenes, Brain and Behavior,which he edited from 2001 to 2011.[27]The standards for the publication of mouse mutant studies that he and his co-editors developed for this journal[28]are gradually being accepted in the field.[29][30][31]Since 2017, Crusio is the editor-in-chief ofBehavioral and Brain Functions[32]and since 2019 co-editor ofAdvances in Experimental Medicine and Biology.[33]He is also an academic editor ofPLoS ONEand served as associate editor ofBehavioral and Brain Sciences(1991–2008) andThe Scientific World Journal(2002-2011). Crusio serves or has served on theeditorial boardsofBehavioral and Brain Functions,Behavior Genetics(1991–1995),Behavioural Brain Research(1997–2007),BMC Neuroscience,BMC Research Notes,Frontiers in Behavioral Neuroscience,Journal of Visualized Experiments,Molecular Brain(2012-2017),Neurogenetics(1998–2006),Physiology and Behavior,andCurrent Opinion in Behavioral Sciences.He edited special issues for the journalsBehavior Genetics,[34]Behavioural Brain Research,[35]Physiology and Behavior(withRobert Gerlai),[36]Hippocampus(withAryeh Routtenberg),[37]andBrain Research Bulletin(with Catherine Belzung and Robert Gerlai).[38]Together with Robert Gerlai he also edited ahandbookonmolecular genetictechniques forbehavioral neuroscience.[39][40][41]Currently, he is editing theCambridge Handbooks in Behavioral Genetics,a series of handbooks published byCambridge University Press,[42]of which the first volume,Behavioral Genetics of the Mouse: Genetics of Behavioral Phenotypes,appeared in 2013.[43][44]Since then, two more volumes have appeared.[45]

Community service

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In 1996, Crusio was one of two co-founders of theInternational Behavioural and Neural Genetics Society,[46]for which he served as member-at-large of the executive committee,treasurer,andpresident(1998–2001).[47]In 2011 he received from this society the "Distinguished Service Award",[48]which is given for exceptional contributions to the field of behavioral neurogenetics.[49]Crusio also served on the executive committees of theBehavior Genetics Association(from which he resigned in protest toGlayde Whitney's 1995 presidential address),[50][51]theEuropean Brain and Behaviour Society,[52]and theInternational Behavioral Neuroscience Society,[53]and has been a President of the Dutch Behavior Genetics Contact Group.[54]He has been a member of several program committees for scientific meetings, most notably the 8th and 10th[55]World Congresses of Psychiatric Geneticsand the 2008, 2009 (co-chair), 2010 (chair), and 2011 (chair) Annual Meetings of the IBNS.[56]

Significant papers

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Scholiahas a profile forWim Crusio(Q120981).

According toGoogle Scholar,Crusio's works have been cited over 10,000 times and he has anh-indexof 46.[57]Some significant papers are:

  • Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse".Journal of Neurogenetics.21(4, Special Retrospective Issue:The Origins of Neurogenetics): 197–208.doi:10.1080/01677060701715827.PMID18161583.S2CID7334116.Original publication:Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (July 1986). "A quantitative-genetic analysis of hippocampal variation in the mouse".Journal of Neurogenetics.3(4): 203–214.doi:10.3109/01677068609106850.PMID3746523.
  • Crusio, W. E.; Schwegler, H.; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution".Brain Research.425(1): 182–185.doi:10.1016/0006-8993(87)90498-7.PMID3427419.S2CID39198617.
  • Crusio, W. E.; Schwegler, H.; van Abeelen, J. H. F. (February 1989). "Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis".Behavioural Brain Research.32(1): 81–88.doi:10.1016/S0166-4328(89)80075-0.PMID2930637.S2CID42291976.
  • Crusio W. E. (November 2001). "Genetic dissection of mouse exploratory behaviour".Behavioural Brain Research.125(1–2): 127–132.doi:10.1016/S0166-4328(01)00280-7.PMID11682103.S2CID28031277.
  • Crusio, W. E.; Goldowitz, D.; Holmes, A.; Wolfer, D. (February 2009)."Standards for the publication of mouse mutant studies".Genes, Brain and Behavior.8(1): 1–4.doi:10.1111/j.1601-183X.2008.00438.x.PMID18778401.S2CID205853147.

References

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  1. ^ab"Wim E. Crusio Curriculum Vitae"(PDF).Wim E. Crusio Blog.February 2016. Archived fromthe original(PDF)on 7 November 2017.Retrieved15 August2018.
  2. ^Brünner, Gerhard (1987). "Crusio, Wim: Die Gattung Anubias (Araceae)". Für Ihre Bücherei.Aquarien Magazin(in German).21(7).
  3. ^Klix, Wolf-Dieter (2009)."Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden".Aqua Planta(in German).34(4): 150–151. Archived fromthe originalon 7 October 2010.Retrieved22 August2010.Announcement of re-issue on CD of 1987 German edition ofAnubiasrevision
  4. ^Crusio, WE (1984).Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis.Meppel:Krips Repro. pp. viii+146+78.Archivedfrom the original on 14 August 2016.Retrieved31 July2016.
  5. ^abc"Curriculum Vitae Wim E. Crusio".Archived fromthe originalon 30 January 2017.Retrieved15 August2018.
  6. ^"Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences".Archived fromthe originalon 27 September 2011.Retrieved11 August2009.
  7. ^"Liste des boursiers 1987/1988".Annales de la Fondation Fyssen.4.1989.
  8. ^"CNIC UMR5228 – Equipe 3 – Neurogénétique comportementale"(in French). Archived fromthe originalon 30 October 2007.Retrieved15 August2009.
  9. ^Deris, Yves."Nouvel arrivant à l'INB, aujourd'hui: Wim CRUSIO"(in French). Institut des Neurosciences de Bordeaux. Archived fromthe originalon 17 July 2009.Retrieved23 August2009.
  10. ^"Crusio Wim".The Aquitaine Institute for Cognitive and Integrative Neuroscience.Archivedfrom the original on 21 October 2014.Retrieved29 December2012.
  11. ^Chapouthier, Georges(1994).La Biologie de la Mémoire.Que sais-je? (in French).Presses Universitaires de France.p. 128.ISBN2-13-046261-8.
  12. ^Crusio, W. E.; Schwegler, H; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution".Brain Research.425(1): 182–185.doi:10.1016/0006-8993(87)90498-7.PMID3427419.S2CID39198617.
  13. ^Schwegler, H; Crusio, W. E.; Brust, I (1990). "Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory".Neuroscience.34(2): 293–298.doi:10.1016/0306-4522(90)90139-U.PMID2333144.S2CID9557091.
  14. ^Crawley, Jacqueline(2007).What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice.John Wiley & Sons. p. 138.ISBN9780470119044.Archivedfrom the original on 10 May 2016.Retrieved8 February2015.
  15. ^Crusio, W. E.; Schwegler, H (April 2005)."Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice".Behavioral and Brain Functions.1(3): 3.doi:10.1186/1744-9081-1-3.PMC1143776.PMID15916698.
  16. ^Morris, R. (2007). "Theories of hippocampal function". InAndersen, P.;Morris, R.;Amaral, D.;Bliss, T.;O'Keefe, J.(eds.).The Hippocampus Book.Oxford, UK: Oxford University Press. pp. 581–713.ISBN978-0-19-510027-3.
  17. ^Willner P (December 1997)."Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation".Psychopharmacology.134(4): 319–329.doi:10.1007/s002130050456.PMID9452163.S2CID40941720.Archivedfrom the original on 30 April 1999.Retrieved15 August2009.
  18. ^Kempermann, G; Kronenberg, G (September 2003). "Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression".Biological Psychiatry.54(5): 499–503.doi:10.1016/S0006-3223(03)00319-6.PMID12946878.S2CID26823096.
  19. ^Mineur, Y. S.; Prasol, D. J.; Belzung, C; Crusio, W. E. (September 2003)."Agonistic behavior and unpredictable chronic mild stress in mice"(PDF).Behavior Genetics.33(5): 513–519.doi:10.1023/A:1025770616068.PMID14574128.S2CID20402648.Retrieved16 August2009.[permanent dead link]
  20. ^abMineur, Y. S.; Belzung, C; Crusio, W. E. (November 2006)."Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice".Behavioural Brain Research.175(1): 43–50.doi:10.1016/j.bbr.2006.07.029.PMID17023061.S2CID28014881.
  21. ^Wahlsten, Douglas (2010).Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience.Academic Press. p. 166.ISBN9780123756756.Archivedfrom the original on 3 June 2016.Retrieved6 February2015.
  22. ^abcMineur, Y. S.; Belzung, C; Crusio, W. E. (December 2007). "Functional implications of decreases in neurogenesis following chronic mild stress in mice".Neuroscience.150(2): 251–259.doi:10.1016/j.neuroscience.2007.09.045.PMID17981399.S2CID25560162.
  23. ^The Dutch-Belgian Fragile X Consortium (July 1994). "Fmr1knockout mice: a model to study fragile X mental retardation ".Cell.78(1): 23–33.doi:10.1016/0092-8674(94)90569-X.PMID8033209.S2CID29674883.
  24. ^Bernardet, M; Crusio, W. E. (2006)."Fmr1 KO mice as a possible model of autistic features".The Scientific World Journal.6:1164–1176.doi:10.1100/tsw.2006.220.PMC5917219.PMID16998604.
  25. ^Mineur, Y. S.; Huynh, L. X.; Crusio, W. E. (March 2006). "Social behavior deficits in theFmr1mutant mouse ".Behavioural Brain Research.168(1): 172–175.doi:10.1016/j.bbr.2005.11.004.PMID16343653.S2CID45731129.
  26. ^Spencer, C. M.; Alekseyenko, O; Serysheva, E; Yuva-Paylor, L. A.; Paylor, R (October 2005)."Altered anxiety-related and social behaviors in theFmr1knockout mouse model of fragile X syndrome ".Genes, Brain and Behavior.4(7): 420–430.doi:10.1111/j.1601-183X.2005.00123.x.PMID16176388.S2CID9094269.
  27. ^Pagel, Mark (7 May 2004)."The order in a billion sequences".Times Higher Education.Archivedfrom the original on 3 April 2012.Retrieved9 July2010.
  28. ^Crusio, W. E.; Goldowitz, D; Holmes, A; Wolfer, D (February 2009)."Standards for the publication of mouse mutant studies".Genes, Brain and Behavior.8(1): 1–4.doi:10.1111/j.1601-183X.2008.00438.x.PMID18778401.S2CID205853147.
  29. ^"Author Guidelines".European Journal of Neuroscience.CiteSeerX10.1.1.721.6506.doi:10.1111/(ISSN)1460-9568.
  30. ^Editorial (September 2009)."Troublesome variability in mouse studies".Nature Neuroscience.12(9): 1075.doi:10.1038/nn0909-1075.PMID19710643.
  31. ^"Preparing your manuscript – Research – Criteria".Behavioral and Brain Functions.BioMed Central.Archivedfrom the original on 3 June 2021.Retrieved5 May2020.
  32. ^"Editorial Board".Behavioral and Brain Functions.BioMed Central.Archivedfrom the original on 19 September 2020.Retrieved25 August2017.
  33. ^"Advances in Experimental Medicine and Biology".Springer Nature.Archivedfrom the original on 30 November 2019.Retrieved30 October2019.
  34. ^Crusio, Wim E. (September 1996). Crusio WE (ed.)."Special issue: The neurobehavioral genetics of aggression".Behavior Genetics.26(5): 459–504.doi:10.1007/BF02359749.PMID8917943.S2CID31579336.Archivedfrom the original on 25 August 2017.Retrieved14 August2009.
  35. ^Crusio WE, ed. (September 1998)."Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics".Behavioural Brain Research.95(1): 1–142.doi:10.1016/S0166-4328(97)00203-9.S2CID208791454.Archivedfrom the original on 13 March 2013.Retrieved14 August2009.
  36. ^Gerlai RT (August 2001). Gerlai RT, Crusio WE (eds.)."Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology".Physiology and Behavior.73(5): 671–886.doi:10.1016/S0031-9384(01)00583-2.S2CID54311109.Archivedfrom the original on 24 September 2015.Retrieved14 August2009.
  37. ^Crusio WE, Routtenberg A (February 2001). Routtenberg A, Crusio WE (eds.)."Special Issue: Gene Targeting and Hippocampal Function".Hippocampus.12(1): 2–3.doi:10.1002/hipo.10001.PMID11918284.S2CID37535269.Archivedfrom the original on 22 October 2012.Retrieved14 August2009.
  38. ^Belzung C, Crusio WE, Gerlai RT (January 2002). Belzung C, Crusio WE, Gerlai RT (eds.)."Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior".Brain Research Bulletin.57(1): 1–131.doi:10.1016/S0361-9230(01)00629-3.PMID11827730.S2CID9742148.Archivedfrom the original on 24 September 2015.Retrieved14 August2009.
  39. ^Crusio, WE; Gerlai, RT (1999).Handbook of Molecular-Genetic Techniques for Brain and Behavior Research.Amsterdam:Elsevier.pp. xxvii+965.ISBN978-0-444-50239-1.
  40. ^"Crusio, W.E. [WorldCat Identities]".Archivedfrom the original on 17 December 2013.Retrieved11 August2009.
  41. ^Skoulakis, Efthimios M.C. (2001). "A tool for synthesis".Trends in Neurosciences.24(2): 127.doi:10.1016/S0166-2236(00)01670-2.S2CID53185722.Reprinted in:Skoulakis, Efthimios M.C (2001). "A tool for synthesis".Trends in Molecular Medicine.7(3): 139.doi:10.1016/S1471-4914(01)01956-6.
  42. ^"Series – Cambridge Handbooks in Behavioral Genetics".Cambridge University Press.Archivedfrom the original on 25 September 2015.Retrieved25 November2012.
  43. ^Mandillo, Silvia (2014)."Book review: Behavioral Genetics of the Mouse".Genes, Brain and Behavior.13(5): 517.doi:10.1111/gbb.12125.
  44. ^Michetti, Caterina (2014)."BEHAVIORAL GENETICS OF THE MOUSE. Genetics of Behavioral Phenotypes. Volume 1"(PDF).Annali dell'Istituto Superiore di Sanità.50(4): 378–379.doi:10.4415/ANN_14_04_14.Archived(PDF)from the original on 8 August 2016.Retrieved31 July2016.
  45. ^"Cambridge Handbooks in Behavioral Genetics".Cambridge, United Kingdom: Cambridge University Press.Archivedfrom the original on 2 October 2021.Retrieved29 October2015.
  46. ^"IBANGS History".IBANGS Homepage.Archived fromthe originalon 26 July 2011.Retrieved1 April2009.
  47. ^"Past Officers and Executive Committee Members".Archivedfrom the original on 9 March 2012.Retrieved9 March2012.
  48. ^"IBANGS Awards".IBANGS Homepage.Archived fromthe originalon 1 October 2011.Retrieved25 November2011.
  49. ^"Call for 2011 IBANGS award nominations".IBANGS Homepage.Archived fromthe originalon 1 October 2011.Retrieved25 November2011.
  50. ^Loehlin, John (1 April 2009)."History of behavior genetics".In Kim, Yong-Kyu (ed.).Handbook of Behavior Genetics.Berlin: Springer. pp. 3–11.ISBN978-0-387-76726-0.Archivedfrom the original on 2 October 2021.Retrieved17 December2020.
  51. ^Panofsky, Aaron (2014).Misbehaving Science. Controversy and the Development of Behavior Genetics.Chicago:University of Chicago Press.pp. 3–4.ISBN978-0-226-05831-3.
  52. ^"Past committee members".Archivedfrom the original on 14 March 2012.Retrieved11 August2009.
  53. ^"IBNS History of Officers".Archived fromthe originalon 21 November 2008.Retrieved11 August2009.
  54. ^Crusio, W.E. (1991)."Obituary Sjeng Kerbusch (1947-1991)".Behavior Genetics.21(5): 431–432.doi:10.1007/BF01066721.S2CID148069790.
  55. ^"Xth World Congress on Psychiatric Genetics – Committees".Archived fromthe originalon 30 September 2002.Retrieved9 July2010.
  56. ^"IBNS Committees/Mission Statements".Archived fromthe originalon 4 May 2009.Retrieved11 August2009.
  57. ^"Wim Crusio".Google Scholar.Retrieved16 May2022.
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