BD1063
(Redirected fromBD-1063)
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| ECHA InfoCard | 100.229.843 |
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| Formula | C13H18Cl2N2 |
| Molar mass | 273.20g·mol−1 |
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BD1063or1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazineis a selectivesigma receptorantagonist,with a reportedbinding affinityofKi= 9 ± 1 nM for thesigma-1 receptorand more than 49 times selectivity over thesigma-2 receptor.[1]
Consistent with other reportedsigma receptorantagonists,pretreating Swiss Webster mice with BD1063 significantly decreases the convulsivity and lethality of cocaine.[1]
In other animal studies, BD1063 blocks the effects ofMDMA,[2]and reduces alcohol intake in rodent models ofalcoholism.[3]
See also
[edit]References
[edit]- ^abMatsumoto RR, McCracken KA, Friedman MJ, Pouw B, De Costa BR, Bowen WD (2001). "Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice".Eur. J. Pharmacol.419(2–3): 163–74.doi:10.1016/s0014-2999(01)00968-2.PMID11426838.
- ^Brammer MK, Gilmore DL, Matsumoto RR (December 2006)."Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors".European Journal of Pharmacology.553(1–3): 141–5.doi:10.1016/j.ejphar.2006.09.038.PMC1780037.PMID17070798.
- ^Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP (May 2009)."The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking".Neuropsychopharmacology.34(6): 1482–93.doi:10.1038/npp.2008.192.PMC2669694.PMID18946467.