From Wikipedia, the free encyclopedia
BIDN
Names
IUPAC name
3,3-Bis(trifluoromethyl)bicyclo[2.2.1]heptane-2,2-dicarbonitrile
Other names
Flucybene
Identifiers
ChemSpider
InChI=1S/C11H8F6N2/c12-10(13,14)9(11(15,16)17)7-2-1-6(3-7)8(9,4-18)5-19/h6-7H,1-3H2
Key: MUIBMWREADMFQF-UHFFFAOYSA-N
C1CC2CC1C(C2(C(F)(F)F)C(F)(F)F)(C#N)C#N
Properties
C 11 H 8 F 6 N 2
Molar mass
282.189 g·mol−1
Hazards
GHS labelling :
Danger
H300
P264 ,P270 ,P301+P310 ,P321 ,P330 ,P405 ,P501
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
BIDN is aGABA receptor antagonist andconvulsant .[ 1]
^ Rauh, James J; Holyoke, Caleb W; Kleier, Daniel A; Presnail, James K; Benner, Eric A; Cordova, Daniel; Howard, Michael H; Hosie, Alastair M; Buckingham, Steven D; Baylis, Howard A; Sattelle, David B (1997). "Polycyclic dinitriles: a novel class of potent GABAergic insecticides provides a new radioligand, [3H]BIDN".Invertebrate Neuroscience .3 (2–3): 261–8.doi :10.1007/bf02480383 .PMID 9783448 .S2CID 33478021 .
Ionotropic
GABAA Tooltip γ-Aminobutyric acid A receptor
Positive modulators (abridged; seehere for a full list): α-EMTBL
Alcohols (e.g.,drinking alcohol ,2M2B )
Anabolic steroids
Avermectins (e.g.,ivermectin )
Barbiturates (e.g.,phenobarbital )
Benzodiazepines (e.g.,diazepam )
Bromide compounds (e.g.,potassium bromide )
Carbamates (e.g.,meprobamate )
Carbamazepine
Chloralose
Chlormezanone
Clomethiazole
Dihydroergolines (e.g.,ergoloid (dihydroergotoxine) )
Etazepine
Etifoxine
Fenamates (e.g.,mefenamic acid )
Flavonoids (e.g.,apigenin ,hispidulin )
Fluoxetine
Flupirtine
Imidazoles (e.g.,etomidate )
Kava constituents (e.g.,kavain )
Lanthanum
Loreclezole
Monastrol
Neuroactive steroids (e.g.,allopregnanolone ,cholesterol ,THDOC )
Niacin
Niacinamide
Nonbenzodiazepines (e.g.,β-carbolines (e.g.,abecarnil ),cyclopyrrolones (e.g.,zopiclone ),imidazopyridines (e.g.,zolpidem ),pyrazolopyrimidines (e.g.,zaleplon ))
Norfluoxetine
Petrichloral
Phenols (e.g.,propofol )
Phenytoin
Piperidinediones (e.g.,glutethimide )
Propanidid
Pyrazolopyridines (e.g.,etazolate )
Quinazolinones (e.g.,methaqualone )
Retigabine (ezogabine)
ROD-188
Skullcap constituents (e.g.,baicalin )
Stiripentol
Sulfonylalkanes (e.g.,sulfonmethane (sulfonal) )
Topiramate
Valerian constituents (e.g.,valerenic acid )
Volatiles /gases (e.g.,chloral hydrate ,chloroform ,diethyl ether ,paraldehyde ,sevoflurane )
Negative modulators: 1,3M1B
3M2B
11-Ketoprogesterone
17-Phenylandrostenol
α3IA
α5IA (LS-193,268)
β-CCB
β-CCE
β-CCM
β-CCP
β-EMGBL
Anabolic steroids
Amiloride
Anisatin
β-Lactams (e.g.,penicillins ,cephalosporins ,carbapenems )
Basmisanil
Bemegride
Bicyclic phosphates (TBPS ,TBPO ,IPTBO )
BIDN
Bilobalide
Bupropion
CHEB
Chlorophenylsilatrane
Cicutoxin
Cloflubicyne
Cyclothiazide
DHEA
DHEA-S
Dieldrin
(+)-DMBB
DMCM
DMPC
EBOB
Etbicyphat
FG-7142 (ZK-31906)
Fiproles (e.g.,fipronil )
Flavonoids (e.g.,amentoflavone ,oroxylin A )
Flumazenil
Fluoroquinolones (e.g.,ciprofloxacin )
Flurothyl
Furosemide
Golexanolone
Iomazenil (123 I)
IPTBO
Isopregnanolone (sepranolone)
L-655,708
Laudanosine
Lindane
MaxiPost
Morphine
Morphine-3-glucuronide
MRK-016
Naloxone
Naltrexone
Nicardipine
Nonsteroidal antiandrogens (e.g.,apalutamide ,bicalutamide ,enzalutamide ,flutamide ,nilutamide )
Oenanthotoxin
Pentylenetetrazol (pentetrazol)
Phenylsilatrane
Picrotoxin (i.e.,picrotin ,picrotoxinin anddihydropicrotoxinin )
Pregnenolone sulfate
Propybicyphat
PWZ-029
Radequinil
Ro 15-4513
Ro 19-4603
RO4882224
RO4938581
Sarmazenil
SCS
Suritozole
TB-21007
TBOB
TBPS
TCS-1105
Terbequinil
TETS
Thujone
U-93631
Zinc
ZK-93426
GABAA -ρ Tooltip γ-Aminobutyric acid A-rho receptor
Metabotropic
GABAB Tooltip γ-Aminobutyric acid B receptor