Barnidipine

Barnidipine

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	C08CA12(WHO)
Identifiers
IUPAC name 3-(3R)-1-Benzylpyrrolidin-3-yl 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number	104713-75-9N
PubChemCID	443869
ChemSpider	391959N
UNII	2VBY96ASWJ
ChEMBL	ChEMBL2103761N
CompTox Dashboard(EPA)	DTXSID20909147
Chemical and physical data
Formula	C27H29N3O6
Molar mass	491.544g·mol−1
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c1cccc(c1)[C@H]4C(/C(=O)OC)=C(\N\C(=C4\C(=O)O[C@H]3CCN(Cc2ccccc2)C3)C)C
InChI InChI=1S/C27H29N3O6/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3/t22-,25-/m0/s1N Key:VXMOONUMYLCFJD-DHLKQENFSA-NN
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Barnidipine(INN;also known asmepirodipine) is acalcium channel blockerwhich belongs to thedihydropyridine(DHP) group ofcalcium channel blockers.It is used in the treatment ofhypertension.

Pharmacodynamics

Barnidipine is a pure S,S isomer, a lipophilic 1,4-dihydropyridine calcium channel blocker, which, like other compounds in the class, shows a high affinity for calcium channels, particularly the L-type slow channels of smooth muscle cells found in the vessel wall.Calcium channel blocking drugs have the characteristic of interfering with the flow of calcium ions into the interior of cells through the slow channels of the plasma membrane.