Chloride transport protein 6is aproteinthat in humans is encoded by theCLCN6gene.[5][6]
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significantsequence homology.Chloride channel 6 and 7 belong to a subbranch of this family. Chloride channel 6 has four different alternatively spliced transcript variants. This gene is in close vicinity to two other kidney-specific chloride channel genes, CLCNKA and CLCNKB.[6]
Eggermont J (1998). "The exon-intron architecture of human chloride channel genes is not conserved".Biochim. Biophys. Acta.1397(2): 156–60.doi:10.1016/s0167-4781(98)00014-1.PMID9565675.
Lamb FS, Clayton GH, Liu BX, et al. (1999). "Expression of CLCN voltage-gated chloride channel genes in human blood vessels".J. Mol. Cell. Cardiol.31(3): 657–66.doi:10.1006/jmcc.1998.0901.PMID10198195.
Kornak U, Bösl MR, Kubisch C (1999). "Complete genomic structure of the CLCN6 and CLCN7 putative chloride channel genes(1)".Biochim. Biophys. Acta.1447(1): 100–6.doi:10.1016/s0167-4781(99)00128-1.PMID10500249.
Lamb FS, Graeff RW, Clayton GH, et al. (2001). "Ontogeny of CLCN3 chloride channel gene expression in human pulmonary epithelium".Am. J. Respir. Cell Mol. Biol.24(4): 376–81.doi:10.1165/ajrcmb.24.4.4114.PMID11306429.
Tran P, Leclerc D, Chan M, et al. (2003). "Multiple transcription start sites and alternative splicing in the methylenetetrahydrofolate reductase gene result in two enzyme isoforms".Mamm. Genome.13(9): 483–92.doi:10.1007/s00335-002-2167-6.PMID12370778.S2CID19722541.