Glutarimide
Appearance
![]() | |
![]() | |
Names | |
---|---|
Preferred IUPAC name
Piperidine-2,6-dione | |
Other names
2,6-Diketopiperidine
| |
Identifiers | |
3D model (JSmol)
|
|
ChemSpider | |
ECHA InfoCard | 100.013.038 |
PubChemCID
|
|
UNII | |
CompTox Dashboard(EPA)
|
|
| |
| |
Properties | |
C5H7NO2 | |
Molar mass | 113.11 g/mol |
Melting point | 155-157 °C[1] |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
|
Glutarimideis theorganic compoundwith the formula (CH2)3(CO)2NH. It is a white solid. The compound forms upon dehydration of the amide ofglutaric acid.[2]
![](https://upload.wikimedia.org/wikipedia/commons/thumb/1/11/Lenalidomide_substructures.svg/220px-Lenalidomide_substructures.svg.png)
Glutarimide is sometimes called 2,6-piperidinedione. It is the core of a variety ofdrugs,includinglenalidomide,a medication used to treatanemiaandmultiple myeloma;[3]andcycloheximide,a potent inhibitor of protein synthesis.[4]
References
[edit]- ^Glutarimide-Sigma-Aldrich
- ^Paris, G.; Berlinguet, L.; Gaudry, R.; English, Jr., J.; Dayan, J. E. (1957). "Glutaric Acid and Glutarimide".Organic Syntheses.37:47.doi:10.15227/orgsyn.037.0047.
- ^"A to Z List of Cancer Drugs: Lenalidomide".National Cancer Institute. 1 September 2022.Retrieved5 August2024.
- ^Sisler, Hugh D.; Siegel, Malcolm R. (1967)."Cycloheximide and Other Glutarimide Antibiotics".Mechanism of Action.pp. 283–307.doi:10.1007/978-3-642-46051-7_21.ISBN978-3-642-46053-1.