ILF2

ILF2
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4AT7,4AT8,4AT9,4ATB
Identifiers
Aliases	ILF2,NF45, PRO3063, interleukin enhancer binding factor 2
External IDs	OMIM:603181;MGI:1915031;HomoloGene:26894;GeneCards:ILF2;OMA:ILF2 - orthologs
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 F1 Start 90,383,433bp End 90,395,686bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in ganglionic eminence islet of Langerhans anterior pituitary rectum body of pancreas skin of abdomen left lobe of thyroid gland left uterine tube right lobe of thyroid gland right adrenal gland Top expressed in ventricular zone tail of embryo genital tubercle ganglionic eminence neural tube abdominal wall medial ganglionic eminence neural layer of retina epiblast embryo More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity DNA binding double-stranded RNA binding protein binding ATP binding RNA binding Cellular component cytoplasm nucleolus membrane nucleus specific granule lumen tertiary granule lumen ficolin-1-rich granule lumen extracellular region ribonucleoprotein complex Biological process positive regulation of transcription, DNA-templated regulation of transcription, DNA-templated immune response transcription, DNA-templated neutrophil degranulation Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 3608 67781 Ensembl n/a ENSMUSG00000001016 UniProt Q12905 Q9CXY6 RefSeq (mRNA) NM_004515 NM_001267809 NM_026374 RefSeq (protein) NP_001254738 NP_004506 NP_080650 Location (UCSC) n/a Chr 3: 90.38 – 90.4 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Interleukin enhancer-binding factor 2is aproteinthat in humans is encoded by theILF2gene.

Function

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component forencapsidationand protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.

Interactions

ILF2 has been shown tointeractwithCDC5LandDNA-PKcs.

ILF2 and ILF3 have been identified as autoantigens in mice with induced lupus,in canine systemic rheumatic autoimmune disease,and as a rare finding in humans with autoimmune disease.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Marcoulatos P, Koussidis G, Mamuris Z, Velissariou V, Vamvakopoulos NC (December 1996). "Mapping interleukin enhancer binding factor 2 gene (ILF2) to human chromosome 1 (1q11-qter and 1p11-p12) by polymerase chain reaction amplification of human-rodent somatic cell hybrid DNA templates".Journal of Interferon & Cytokine Research.16(12): 1035–8.doi:10.1089/jir.1996.16.1035.PMID8974006.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Ting NS, Kao PN, Chan DW, Lintott LG, Lees-Miller SP (January 1998)."DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45".The Journal of Biological Chemistry.273(4): 2136–45.CiteSeerX10.1.1.615.1747.doi:10.1074/jbc.273.4.2136.PMID9442054.
• Langland JO, Kao PN, Jacobs BL (May 1999). "Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR".Biochemistry.38(19): 6361–8.doi:10.1021/bi982410u.PMID10320367.
• Satoh M, Shaheen VM, Kao PN, Okano T, Shaw M, Yoshida H, Richards HB, Reeves WH (December 1999)."Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity".The Journal of Biological Chemistry.274(49): 34598–604.doi:10.1074/jbc.274.49.34598.PMID10574923.
• Ajuh P, Kuster B, Panov K, Zomerdijk JC, Mann M, Lamond AI (December 2000)."Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry".The EMBO Journal.19(23): 6569–81.doi:10.1093/emboj/19.23.6569.PMC305846.PMID11101529.
• Parker LM, Fierro-Monti I, Mathews MB (August 2001)."Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase".The Journal of Biological Chemistry.276(35): 32522–30.doi:10.1074/jbc.M104408200.PMID11438540.
• Reichman TW, Muñiz LC, Mathews MB (January 2002)."The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells".Molecular and Cellular Biology.22(1): 343–56.doi:10.1128/MCB.22.1.343-356.2002.PMC134226.PMID11739746.
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (January 2002)."Directed proteomic analysis of the human nucleolus".Current Biology.12(1): 1–11.Bibcode:2002CBio...12....1A.doi:10.1016/S0960-9822(01)00650-9.PMID11790298.S2CID14132033.
• Shin HJ, Kim SS, Cho YH, Lee SG, Rho HM (March 2002)."Host cell proteins binding to the encapsidation signal epsilon in hepatitis B virus RNA".Archives of Virology.147(3): 471–91.doi:10.1007/s007050200001.PMID11958450.S2CID23653290.
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (November 2002)."Functional proteomic analysis of human nucleolus".Molecular Biology of the Cell.13(11): 4100–9.doi:10.1091/mbc.E02-05-0271.PMC133617.PMID12429849.
• Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG (November 2003)."Regulation of alternative splicing by SRrp86 and its interacting proteins".Molecular and Cellular Biology.23(21): 7437–47.doi:10.1128/MCB.23.21.7437-7447.2003.PMC207616.PMID14559993.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). "Nucleolar proteome dynamics".Nature.433(7021): 77–83.Bibcode:2005Natur.433...77A.doi:10.1038/nature03207.PMID15635413.S2CID4344740.
• Zhao G, Shi L, Qiu D, Hu H, Kao PN (May 2005). "NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function".Experimental Cell Research.305(2): 312–23.doi:10.1016/j.yexcr.2004.12.030.PMID15817156.
• Nie Y, Ding L, Kao PN, Braun R, Yang JH (August 2005)."ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing".Molecular and Cellular Biology.25(16): 6956–63.doi:10.1128/MCB.25.16.6956-6963.2005.PMC1190226.PMID16055709.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY,Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.

External links

• ILF2+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• PDBe-KBprovides an overview of all the structure information available in the PDB for Mouse Interleukin enhancer-binding factor 2 (ILF2)

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.