RCS-8

RCS-8
Legal status
Legal status	CA:Schedule II; DE:NpSG(Industrial and scientific use only); UK:Class B; US:Schedule I;
Identifiers
	IUPAC name 2-(2-Methoxyphenyl)-1-[1-(2-cyclohexylethyl)indol-3-yl]ethanone;
CAS Number	1345970-42-4[SciFinder];
ChemSpider	24751863;
UNII	11030I5W3R;
CompTox Dashboard(EPA)	DTXSID30158821;
Chemical and physical data
Formula	C25H29NO2
Molar mass	375.512g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1ccccc1CC(=O)c2cn(c3c2cccc3)CCC4CCCCC4;
	InChI InChI=1S/C25H29NO2/c1-28-25-14-8-5-11-20(25)17-24(27)22-18-26(23-13-7-6-12-21(22)23)16-15-19-9-3-2-4-10-19/h5-8,11-14,18-19H,2-4,9-10,15-17H2,1H3; Key:BSQFBMXCQIKYNI-UHFFFAOYSA-N;
	(what is this?)(verify)

RCS-8(also known as1-(2-cyclohexylethyl)-3-(2-methoxyphenylacetyl)indole,SR-18,andBTM-8) is asynthetic cannabinoidthat has been found as an ingredient of "herbal"synthetic cannabisblends. It can be described as an analogue ofJWH-250with the 1-pentyl group replaced by 1-(2-cyclohexylethyl), and can be expected to be less potent than JWH-250 (cf.JWH-007and its cyclohexylethyl analogue).^[1]Despite not having been reported in the scientific or patent literature as yet, reputed recreational use of RCS-8 in the United States has led to it being specifically listed in a proposed 2011 amendment to theControlled Substances Act,aiming to add a number of synthetic drugs intoSchedule I.^[2]In addition, all CB₁receptor agonists of the 3-phenylacetylindole class such as RCS-8 areSchedule I Controlled Substances.^[3]

References

^Huffman JW, Dai D, Martin BR, Compton DR (1994). "Design, Synthesis and Pharmacology of Cannabimimetic Indoles".Bioorganic & Medicinal Chemistry Letters.4(4): 563–566.doi:10.1016/S0960-894X(01)80155-4.
^Synthetic Drug Control Act of 2011
^21 U.S.C.§ 812:Schedules of controlled substances

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[1] Huffman JW, Dai D, Martin BR, Compton DR (1994). "Design, Synthesis and Pharmacology of Cannabimimetic Indoles".Bioorganic & Medicinal Chemistry Letters.4(4): 563–566.doi:10.1016/S0960-894X(01)80155-4.

[2] Synthetic Drug Control Act of 2011

[3] 21 U.S.C.§ 812:Schedules of controlled substances

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See also

References