TSC22D3
TSC22 domain family protein 3is aproteinthat in humans is encoded by theTSC22D3gene.[5][6]
Function
[edit]The protein encoded by this gene shares significant sequence identity with the murine TSC-22 and Drosophila shs, both of which are leucine zipper proteins, that function as transcriptional regulators. GILZ shows ubiquitous expression across tissues, including thymus, spleen, lung, fat, liver, kidney, heart, and skeletal muscle.[7][8]The expression of this gene is stimulated by glucocorticoids and interleukin 10, and it appears to play a key role in the anti-inflammatory and immunosuppressive effects of this steroid and chemokine. Transcript variants encoding different isoforms have been identified for this gene.[6]
Interactions
[edit]TSC22D3 has been shown tointeractwithC-Raf,[9]NFKB2[10]andNFKB1.[10]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000157514–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000031431–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Vogel P, Mägert HJ, Cieslak A, Adermann K, Forssmann WG (Dec 1996). "hDIP--a potential transcriptional regulator related to murine TSC-22 and Drosophila shortsighted (shs)--is expressed in a large number of human tissues".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1309(3): 200–4.doi:10.1016/s0167-4781(96)00177-7.PMID8982256.
- ^ab"Entrez Gene: TSC22D3 TSC22 domain family, member 3".
- ^Ayyar, Vivaswath S.; Almon, Richard R.; Jusko, William J.; DuBois, Debra C. (2015-06-01)."Quantitative tissue-specific dynamics of in vivo GILZ mRNA expression and regulation by endogenous and exogenous glucocorticoids".Physiological Reports.3(6): e12382.doi:10.14814/phy2.12382.PMC4510616.PMID26056061.
- ^Cannarile, L.; Zollo, O.; D'Adamio, F.; Ayroldi, E.; Marchetti, C.; Tabilio, A.; Bruscoli, S.; Riccardi, C. (2001-02-01)."Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene".Cell Death and Differentiation.8(2): 201–203.doi:10.1038/sj.cdd.4400798.ISSN1350-9047.PMID11313722.
- ^Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002)."Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1".Molecular and Cellular Biology.22(22): 7929–41.doi:10.1128/MCB.22.22.7929-7941.2002.PMC134721.PMID12391160.
- ^abAyroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB".Blood.98(3): 743–53.doi:10.1182/blood.V98.3.743.PMID11468175.
Further reading
[edit]- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A" double adaptor "method for improved shotgun library construction".Analytical Biochemistry.236(1): 107–13.doi:10.1006/abio.1996.0138.PMID8619474.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997)."Large-scale concatenation cDNA sequencing".Genome Research.7(4): 353–8.doi:10.1101/gr.7.4.353.PMC139146.PMID9110174.
- Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001)."Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs".Genome Research.11(3): 422–35.doi:10.1101/gr.GR1547R.PMC311072.PMID11230166.
- Cannarile L, Zollo O, D'Adamio F, Ayroldi E, Marchetti C, Tabilio A, Bruscoli S, Riccardi C (Feb 2001)."Cloning, chromosomal assignment and tissue distribution of human GILZ, a glucocorticoid hormone-induced gene".Cell Death and Differentiation.8(2): 201–3.doi:10.1038/sj.cdd.4400798.PMID11313722.
- Mittelstadt PR, Ashwell JD (Aug 2001)."Inhibition of AP-1 by the glucocorticoid-inducible protein GILZ".The Journal of Biological Chemistry.276(31): 29603–10.doi:10.1074/jbc.M101522200.PMID11397794.
- Ayroldi E, Migliorati G, Bruscoli S, Marchetti C, Zollo O, Cannarile L, D'Adamio F, Riccardi C (Aug 2001). "Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB".Blood.98(3): 743–53.doi:10.1182/blood.V98.3.743.PMID11468175.
- Ayroldi E, Zollo O, Macchiarulo A, Di Marco B, Marchetti C, Riccardi C (Nov 2002)."Glucocorticoid-induced leucine zipper inhibits the Raf-extracellular signal-regulated kinase pathway by binding to Raf-1".Molecular and Cellular Biology.22(22): 7929–41.doi:10.1128/MCB.22.22.7929-7941.2002.PMC134721.PMID12391160.
- Berrebi D, Bruscoli S, Cohen N, Foussat A, Migliorati G, Bouchet-Delbos L, Maillot MC, Portier A, Couderc J, Galanaud P, Peuchmaur M, Riccardi C, Emilie D (Jan 2003)."Synthesis of glucocorticoid-induced leucine zipper (GILZ) by macrophages: an anti-inflammatory and immunosuppressive mechanism shared by glucocorticoids and IL-10".Blood.101(2): 729–38.doi:10.1182/blood-2002-02-0538.PMID12393603.
- Shi X, Shi W, Li Q, Song B, Wan M, Bai S, Cao X (Apr 2003)."A glucocorticoid-induced leucine-zipper protein, GILZ, inhibits adipogenesis of mesenchymal cells".EMBO Reports.4(4): 374–80.doi:10.1038/sj.embor.embor805.PMC1319161.PMID12671681.
- Asselin-Labat ML, David M, Biola-Vidamment A, Lecoeuche D, Zennaro MC, Bertoglio J, Pallardy M (Jul 2004)."GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis".Blood.104(1): 215–23.doi:10.1182/blood-2003-12-4295.PMID15031210.
- Asselin-Labat ML, Biola-Vidamment A, Kerbrat S, Lombès M, Bertoglio J, Pallardy M (Jul 2005)."FoxO3 mediates antagonistic effects of glucocorticoids and interleukin-2 on glucocorticoid-induced leucine zipper expression".Molecular Endocrinology.19(7): 1752–64.doi:10.1210/me.2004-0206.PMID15705665.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
- Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D (Dec 2005)."A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport".The Journal of Biological Chemistry.280(48): 39970–81.doi:10.1074/jbc.M508658200.PMID16216878.
- Hamdi H, Godot V, Maillot MC, Prejean MV, Cohen N, Krzysiek R, Lemoine FM, Zou W, Emilie D (Jul 2007)."Induction of antigen-specific regulatory T lymphocytes by human dendritic cells expressing the glucocorticoid-induced leucine zipper".Blood.110(1): 211–9.doi:10.1182/blood-2006-10-052506.PMC2077304.PMID17356131.