3-Methyl-GABA

3-Methyl-GABA
Names
	IUPAC name 4-Amino-3-methylbutanoic acid
	Other names HMS3266K11; HMS3411G19;
Identifiers
CAS Number	71135-23-4;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:93881;
ChEMBL	ChEMBL275655;
ChemSpider	2778160;
PubChemCID	3539719;
	InChI InChI=1S/C5H11NO2/c1-4(3-6)2-5(7)8/h4H,2-3,6H2,1H3,(H,7,8) Key: CZGLBWZXGIAIBU-UHFFFAOYSA-N;
	SMILES CC(CC(=O)O)CN;
Properties
Chemical formula	C5H11NO2
Molar mass	117.148g·mol−1
	Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa). Infobox references

3-Methyl-GABA,also known asHMS3266K11,is ananticonvulsant alkaloid.

Pharmacology

3-Methyl-GABAis an activator ofGABA-T,an enzyme that transformsGABAtosuccinate semialdehydeandglutamate.

It also activatesglutamate decarboxylase,an enzyme that is needed in GABA synthesis. This is thought to be the primary mechanism of action behind its anticonvulsant action.^[1]

References

^Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase".Journal of Medicinal Chemistry.34(7): 2295–2298.doi:10.1021/jm00111a053.PMID 2067001.

[1] Silverman RB, Andruszkiewicz R, Nanavati SM, Taylor CP, Vartanian MG (July 1991). "3-Alkyl-4-aminobutyric acids: the first class of anticonvulsant agents that activates L-glutamic acid decarboxylase".Journal of Medicinal Chemistry.34(7): 2295–2298.doi:10.1021/jm00111a053.PMID 2067001.

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