4-Dimethylaminophenol
Appearance
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Names | |
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Preferred IUPAC name
4-(Dimethylamino)phenol | |
Identifiers | |
3D model (JSmol)
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ChemSpider | |
ECHA InfoCard | 100.009.642 |
PubChemCID
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UNII | |
CompTox Dashboard(EPA)
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Properties | |
C8H11NO | |
Molar mass | 137.179 g/mol |
Boiling point | 165 °C (329 °F; 438 K) (0.040 bar) |
Pharmacology | |
V03AB27(WHO) | |
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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4-Dimethylaminophenol(DMAP) is an aromatic compound containing bothphenolandaminefunctional groups. It has the molecular formula C8H11NO.
Uses
[edit]4-Dimethylaminophenol has been used as anantidoteforcyanide poisoning.[1]It has also been shown to be effective in treatinghydrogen sulfidetoxicity.[2]
It works by generatingmethemoglobin.[3]
This is suitable as an emergency treatment only; treatment must be followed up withsodium thiosulfateorcobalamin.
In an animal model, it has shown effectiveness when givenintramuscularly.[4]Though,intramuscular injectionshould be avoid due to the probability ofmuscular necrosisafter injection.Intravenous injectionis recommended in a dose of 250 mg.[5]
See also
[edit]References
[edit]- ^Kampe S, Iffland R, Korenkov M, Diefenbach C (December 2000)."Survival from a lethal blood concentration of cyanide with associated alcohol intoxication: Case report".Anaesthesia.55(12): 1189–1191.doi:10.1046/j.1365-2044.2000.01628.x.PMID11121929.S2CID32892580.
- ^Lindenmann J, Matzi V, Neuboeck N, Ratzenhofer-Komenda B, Maier A, Smolle-Juettner FM (December 2010)."Severe hydrogen sulphide poisoning treated with 4-dimethylaminophenol and hyperbaric oxygen".Diving and Hyperbaric Medicine.40(4): 213–217.ISSN1833-3516.PMID23111938.Retrieved2023-10-08.
- ^Vick JA, Von Bredow JD (1996)."Effectiveness of intramuscularly administered cyanide antidotes on methemoglobin formation and survival".J Appl Toxicol.16(6): 509–16.doi:10.1002/(SICI)1099-1263(199611)16:6<509::AID-JAT382>3.0.CO;2-V.PMID8956097.S2CID36140034.
- ^Vick JA, Froehlich H (July 1991)."Treatment of cyanide poisoning".Mil Med.156(7): 330–9.doi:10.1093/milmed/156.7.330.PMID1922842.
- ^Federation of American Scientists (1 February 1996).NATO HANDBOOK ON THE MEDICAL ASPECTS OF NBC DEFENSIVE OPERATIONS(PDF).p. 334.