5-IAI
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| Routes of administration | Oral,Insufflated,Rectal |
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| Formula | C9H10IN |
| Molar mass | 259.090g·mol−1 |
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5-Iodo-2-aminoindane(5-IAI) is adrugwhich acts as areleasing agentofserotonin,norepinephrine,anddopamine.[2]It was developed in the 1990s by a team led byDavid E. NicholsatPurdue University.[3]5-IAI fully substitutes forMDMAin rodents and is a putativeentactogenin humans.[3]Unlike relatedaminoindanederivatives likeMDAIandMMAI,5-IAI causes someserotonergicneurotoxicityin rats, but is substantially less toxic than its correspondingamphetaminehomologuepIA,with the damage observed barely reaching statistical significance.[2]
Legal status
[edit]Sweden's public health agency suggested classifying 5-IAI as a hazardous substance, on September 25, 2019.[4]
References
[edit]- ^Anvisa(2023-07-24)."RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial"[Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese).Diário Oficial da União(published 2023-07-25).Archivedfrom the original on 2023-08-27.Retrieved2023-08-27.
- ^abJohnson MP, Conarty PF, Nichols DE (July 1991). "[3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues".European Journal of Pharmacology.200(1): 9–16.doi:10.1016/0014-2999(91)90659-E.PMID1685125.
- ^abNichols DE, Johnson MP, Oberlender R (January 1991). "5-Iodo-2-aminoindan, a nonneurotoxic analogue of p-iodoamphetamine".Pharmacology Biochemistry and Behavior.38(1): 135–9.doi:10.1016/0091-3057(91)90601-W.PMID1826785.S2CID20485505.
- ^"Tretton ämnen föreslås klassas som narkotika eller hälsofarlig vara"(in Swedish). Folkhälsomyndigheten. 25 September 2019. Archived fromthe originalon 31 October 2019.Retrieved11 November2019.