ALPI

ALPI
Identifiers
Aliases	ALPI,IAP, alkaline phosphatase, intestinal
External IDs	OMIM:171740;MGI:87984;HomoloGene:134333;GeneCards:ALPI;OMA:ALPI - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q37.1 Start 232,456,125bp End 232,460,753bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 C5|1 44.06 cM Start 87,052,695bp End 87,055,634bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in jejunal mucosa duodenum mucosa of ileum mucosa of transverse colon rectum human kidney muscle tissue smooth muscle tissue appendix gallbladder Top expressed in duodenum embryo jejunum temporal muscle upper arm secretory cell colon triceps brachii muscle mucous cell of stomach midbrain tectum More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding phosphatase activity zinc ion binding protein binding catalytic activity hydrolase activity magnesium ion binding metal ion binding alkaline phosphatase activity Cellular component integral component of membrane anchored component of membrane membrane extracellular region plasma membrane Biological process metabolism dephosphorylation phosphatidic acid biosynthetic process digestion Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 248 11648 Ensembl ENSG00000163295 ENSMUSG00000036500 UniProt P09923 P24822 RefSeq (mRNA) NM_001631 NM_007432 RefSeq (protein) NP_001622 n/a Location (UCSC) Chr 2: 232.46 – 232.46 Mb Chr 1: 87.05 – 87.06 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Alkaline phosphatase, intestinalalso known asALPIis a type ofalkaline phosphatasethat in humans is encoded by theALPIgene.

Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine.In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.

External links

• HumanALPIgenome location andALPIgene details page in theUCSC Genome Browser.

Further reading

• Hirasaka K, Tokuoka K, Nakao R, Yamada C, Oarada M, Imagawa T, et al. (April 2008)."Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells".The Journal of Physiological Sciences.58(2): 105–111.doi:10.2170/physiolsci.RP013007.PMID18307834.
• Mahmood A, Shao JS, Alpers DH (August 2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding".American Journal of Physiology. Gastrointestinal and Liver Physiology.285(2): G433–G441.doi:10.1152/ajpgi.00466.2002.PMID12660142.S2CID30731288.
• Wada A, Wang AP, Isomoto H, Satomi Y, Takao T, Takahashi A, et al. (January 2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin".International Journal of Medical Microbiology.294(7): 427–435.doi:10.1016/j.ijmm.2004.09.012.PMID15715171.
• Nakano T, Inoue I, Alpers DH, Akiba Y, Katayama S, Shinozaki R, et al. (July 2009)."Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration".American Journal of Physiology. Gastrointestinal and Liver Physiology.297(1): G207–G214.doi:10.1152/ajpgi.90590.2008.PMC3817256.PMID19407215.
• Malo MS, Zhang W, Alkhoury F, Pushpakaran P, Abedrapo MA, Mozumder M, et al. (August 2004)."Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element".Molecular Endocrinology.18(8): 1941–1962.doi:10.1210/me.2003-0351.PMID15143152.
• Rump A, Kasper G, Hayes C, Wen G, Starke H, Liehr T, et al. (April 2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1".Genomics.73(1): 50–55.doi:10.1006/geno.2000.6504.PMID11352565.
• Nauli AM, Zheng S, Yang Q, Li R, Jandacek R, Tso P (April 2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation".American Journal of Physiology. Gastrointestinal and Liver Physiology.284(4): G583–G587.doi:10.1152/ajpgi.00482.2002.PMID12466148.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Research.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID16344560.
• Alkhoury F, Malo MS, Mozumder M, Mostafa G, Hodin RA (August 2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2".American Journal of Physiology. Gastrointestinal and Liver Physiology.289(2): G285–G290.doi:10.1152/ajpgi.00037.2005.PMID15774940.
• Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (December 2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity".Seminars in Oncology.29(6 Suppl 19): 14–21.doi:10.1053/sonc.2002.37356.PMID12577238.
• Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease".Pathology, Research and Practice.203(6): 485–487.doi:10.1016/j.prp.2007.02.003.PMID17498884.
• Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, et al. (January 2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor".American Journal of Physiology. Gastrointestinal and Liver Physiology.286(1): G23–G30.doi:10.1152/ajpgi.00203.2003.PMID12919939.
• Le Du MH, Millan JL (December 2002)."Structural evidence of functional divergence in human alkaline phosphatases".The Journal of Biological Chemistry.277(51): 49808–49814.doi:10.1074/jbc.M207394200.PMID12372831.
• Goldberg RF, Austen WG, Zhang X, Munene G, Mostafa G, Biswas S, et al. (March 2008)."Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition".Proceedings of the National Academy of Sciences of the United States of America.105(9): 3551–3556.Bibcode:2008PNAS..105.3551G.doi:10.1073/pnas.0712140105.PMC2265168.PMID18292227.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proceedings of the National Academy of Sciences of the United States of America.101(33): 12130–12135.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC514446.PMID15302935.
• Olsen L, Bressendorff S, Troelsen JT, Olsen J (August 2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells".American Journal of Physiology. Gastrointestinal and Liver Physiology.289(2): G220–G226.doi:10.1152/ajpgi.00449.2004.PMID15831710.S2CID16852841.
• Fumoto K,Hoogenraad CC,Kikuchi A (December 2006)."GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome".The EMBO Journal.25(24): 5670–5682.doi:10.1038/sj.emboj.7601459.PMC1698904.PMID17139249.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Molecular Systems Biology.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.