Alkaline phosphatase, intestinalalso known asALPIis a type ofalkaline phosphatasethat in humans is encoded by theALPIgene.[5][6]
Intestinal alkaline phosphatase is an endogenous protein that plays an essential function in the maintenance of gut homeostasis. The protein is responsible for detoxifying bacterial toxins, dephosphorylating phosphorylated nucleotides, regulating lipid absorption in the intestine, and regulating the microbiome in the intestine.[7]In addition to these functions, intestinal alkaline phosphatase can also modulate bicarbonate secretion and can modulate the pH of the duodenum.[8]
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Wada A, Wang AP, Isomoto H, Satomi Y, Takao T, Takahashi A, et al. (January 2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin".International Journal of Medical Microbiology.294(7): 427–435.doi:10.1016/j.ijmm.2004.09.012.PMID15715171.
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Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (December 2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity".Seminars in Oncology.29(6 Suppl 19): 14–21.doi:10.1053/sonc.2002.37356.PMID12577238.
Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease".Pathology, Research and Practice.203(6): 485–487.doi:10.1016/j.prp.2007.02.003.PMID17498884.
Hinnebusch BF, Siddique A, Henderson JW, Malo MS, Zhang W, Athaide CP, et al. (January 2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor".American Journal of Physiology. Gastrointestinal and Liver Physiology.286(1): G23–G30.doi:10.1152/ajpgi.00203.2003.PMID12919939.
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