Aquaporin-8

AQP8
Identifiers
Aliases	AQP8,AQP-8, aquaporin 8
External IDs	OMIM:603750;MGI:1195271;HomoloGene:68166;GeneCards:AQP8;OMA:AQP8 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16p12.1 Start 25,215,731bp End 25,228,932bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 F3|7 67.42 cM Start 123,061,514bp End 123,067,227bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in mucosa of transverse colon body of pancreas mucosa of ileum rectum mucosa of sigmoid colon testicle pancreatic epithelial cell epithelium of colon islet of Langerhans cerebellar hemisphere Top expressed in left colon left lobe of liver lacrimal gland spermatocyte blastocyst yolk sac embryo parotid gland seminiferous tubule spermatid More reference expression data BioGPS More reference expression data
Gene ontology Molecular function water channel activity channel activity Cellular component integral component of membrane plasma membrane apical part of cell integral component of plasma membrane membrane mitochondrion mitochondrial membranes Biological process ion transmembrane transport cellular response to cAMP water transport transmembrane transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 343 11833 Ensembl ENSG00000103375 ENSMUSG00000030762 UniProt O94778 P56404 RefSeq (mRNA) NM_001169 NM_001109045 NM_007474 RefSeq (protein) NP_001160 NP_001102515 NP_031500 Location (UCSC) Chr 16: 25.22 – 25.23 Mb Chr 7: 123.06 – 123.07 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Aquaporin-8is aproteinthat in humans is encoded by theAQP8gene.

Aquaporin-8 (AQP-8) is a water channel protein.Aquaporinsare a family of small integral membrane proteins related to themajor intrinsic protein(MIP or AQP0). Aquaporin-8 mRNA is found in pancreas and colon but not other tissues.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Harrington DJ, Adachi K, Royer WE (1997)."The high resolution crystal structure of deoxyhemoglobin S".J. Mol. Biol.272(3): 398–407.doi:10.1006/jmbi.1997.1253.PMID9325099.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Fischer H, Stenling R, Rubio C, Lindblom A (2003)."Differential expression of Aquaporin 8 in human colonic epithelial cells and colorectal tumors".BMC Physiol.1:1.doi:10.1186/1472-6793-1-1.PMC32180.PMID11231887.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression".Nat. Biotechnol.19(5): 440–5.doi:10.1038/88107.PMID11329013.S2CID25064683.
• Wang S, Kallichanda N, Song W, et al. (2001). "Expression of aquaporin-8 in human placenta and chorioamniotic membranes: evidence of molecular mechanism for intramembranous amniotic fluid resorption".Am. J. Obstet. Gynecol.185(5): 1226–31.doi:10.1067/mob.2001.117971.PMID11717661.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in human WISH cells".Am. J. Obstet. Gynecol.188(4): 997–1001.doi:10.1067/mob.2003.214.PMID12712100.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Zahn A, Moehle C, Langmann T, et al. (2007)."Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis".World J. Gastroenterol.13(11): 1687–95.doi:10.3748/wjg.v13.i11.1687.PMC4146947.PMID17461471.

External links

• AQP8+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• HumanAQP8genome location andAQP8gene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.