ARID2
AT-rich interactive domain-containing protein 2(ARID2) is aproteinthat in humans is encoded by theARID2gene.[5]
Function[edit]
ARID2 is asubunitof the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activationby nuclear receptors.[5]
Structure[edit]
The ARID2 protein contains twoconservedC-terminalC2H2zinc fingersmotifs, a region rich in theamino acidresiduesprolineandglutamine,a RFX (regulatory factor X)-type winged-helixDNA-binding domain,and a conservedN-terminalAT-rich DNA interaction domain—the last domain for which the protein is named.[6]
Clinical significance[edit]
Mutation studies have revealed ARID2 to be a significanttumor suppressorin many cancer subtypes.ARID2mutations are prevalent inhepatocellular carcinoma[7]andmelanoma.[8][9]Mutations are present in a smaller but significant fraction in a wide range of other tumors.[10]ARID2mutations are enriched inhepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overallmutation frequency.[6]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000189079–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000033237–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: ARID2 AT rich interactive domain 2 (ARID, RFX-like)".
- ^abZhao H, Wang J, Han Y, Huang Z, Ying J, Bi X, Zhao J, Fang Y, Zhou H, Zhou J, Li Z, Zhang Y, Yang X, Yan T, Wang L, Torbenson MS, Cai J (Nov 2011)."ARID2: a new tumor suppressor gene in hepatocellular carcinoma".Oncotarget.2(11): 886–91.doi:10.18632/oncotarget.355.PMC3259997.PMID22095441.
- ^Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW (Sep 2011)."Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma".Nature Genetics.43(9): 828–9.doi:10.1038/ng.903.PMC3163746.PMID21822264.
- ^Hodis E, Watson IR, Kryukov GV, Arold ST, Imielinski M, Theurillat JP, Nickerson E, Auclair D, Li L, Place C, Dicara D, Ramos AH, Lawrence MS, Cibulskis K, Sivachenko A, Voet D, Saksena G, Stransky N, Onofrio RC, Winckler W, Ardlie K, Wagle N, Wargo J, Chong K, Morton DL, Stemke-Hale K, Chen G, Noble M, Meyerson M, Ladbury JE, Davies MA, Gershenwald JE, Wagner SN, Hoon DS, Schadendorf D, Lander ES, Gabriel SB, Getz G, Garraway LA, Chin L (Jul 2012)."A landscape of driver mutations in melanoma".Cell.150(2): 251–63.doi:10.1016/j.cell.2012.06.024.PMC3600117.PMID22817889.
- ^Krauthammer M, Kong Y, Ha BH, Evans P, Bacchiocchi A, McCusker JP, Cheng E, Davis MJ, Goh G, Choi M, Ariyan S, Narayan D, Dutton-Regester K, Capatana A, Holman EC, Bosenberg M, Sznol M, Kluger HM, Brash DE, Stern DF, Materin MA, Lo RS, Mane S, Ma S, Kidd KK, Hayward NK, Lifton RP, Schlessinger J, Boggon TJ, Halaban R (Sep 2012)."Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma".Nature Genetics.44(9): 1006–14.doi:10.1038/ng.2359.PMC3432702.PMID22842228.
- ^Shain AH, Pollack JR (2013)."The spectrum of SWI/SNF mutations, ubiquitous in human cancers".PLOS ONE.8(1): e55119.Bibcode:2013PLoSO...855119S.doi:10.1371/journal.pone.0055119.PMC3552954.PMID23355908.
Further reading[edit]
- Martens JA, Winston F (Apr 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes".Current Opinion in Genetics & Development.13(2): 136–42.doi:10.1016/S0959-437X(03)00022-4.PMID12672490.
- Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000)."Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Research.7(4): 273–81.doi:10.1093/dnares/7.4.271.PMID10997877.
- Mohrmann L, Langenberg K, Krijgsveld J, Kal AJ, Heck AJ, Verrijzer CP (Apr 2004)."Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes".Molecular and Cellular Biology.24(8): 3077–88.doi:10.1128/MCB.24.8.3077-3088.2004.PMC381637.PMID15060132.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation".Nature Biotechnology.22(6): 707–16.doi:10.1038/nbt971.PMID15146197.S2CID27764390.
- Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (Aug 2004)."Identification of interaction partners and substrates of the cyclin A1-CDK2 complex".The Journal of Biological Chemistry.279(32): 33727–41.doi:10.1074/jbc.M401708200.PMID15159402.
- Patsialou A, Wilsker D, Moran E (2005)."DNA-binding properties of ARID family proteins".Nucleic Acids Research.33(1): 66–80.doi:10.1093/nar/gki145.PMC546134.PMID15640446.
- Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW, Moran E (Aug 2005). "Nomenclature of the ARID family of DNA-binding proteins".Genomics.86(2): 242–51.doi:10.1016/j.ygeno.2005.03.013.PMID15922553.
- Yan Z, Cui K, Murray DM, Ling C, Xue Y, Gerstein A, Parsons R, Zhao K, Wang W (Jul 2005)."PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes".Genes & Development.19(14): 1662–7.doi:10.1101/gad.1323805.PMC1176002.PMID15985610.
- Zhang X, Azhar G, Zhong Y, Wei JY (Aug 2006). "Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation".Biochemical and Biophysical Research Communications.346(3): 794–801.doi:10.1016/j.bbrc.2006.05.211.PMID16782067.
External links[edit]
- ARID2+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- HumanARID2genome location andARID2gene details page in theUCSC Genome Browser.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.