ATP1B1

ATP1B1
Identifiers
Aliases	ATP1B1,ATP1B, ATPase Na+/K+ transporting subunit beta 1
External IDs	OMIM:182330;MGI:88108;HomoloGene:37509;GeneCards:ATP1B1;OMA:ATP1B1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.2 Start 169,105,697bp End 169,310,992bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H2.2|1 71.75 cM Start 164,264,678bp End 164,285,924bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in pars compacta lateral nuclear group of thalamus renal medulla pars reticulata pons Epithelium of choroid plexus superior vestibular nucleus external globus pallidus Brodmann area 23 postcentral gyrus Top expressed in olfactory tubercle medial vestibular nucleus lateral septal nucleus left colon amygdala nucleus accumbens subiculum medial dorsal nucleus cerebellar vermis prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase binding potassium ion binding sodium ion binding P-type sodium:potassium-exchanging transporter activity ATPase activity protein C-terminus binding protein binding MHC class II protein complex binding ATPase activator activity ATP binding protein kinase binding Cellular component extracellular vesicle integral component of membrane membrane intercalated disc myelin sheath plasma membrane intracellular anatomical structure sodium:potassium-exchanging ATPase complex basolateral plasma membrane apical plasma membrane caveola sarcolemma extracellular exosome Biological process regulation of cardiac conduction regulation of cardiac muscle contraction by calcium ion signaling response to hypoxia positive regulation of ATP-dependent activity cardiac muscle contraction positive regulation of sodium ion export across plasma membrane sodium ion transport cellular sodium ion homeostasis sodium ion export across plasma membrane metal ion transport cell communication by electrical coupling involved in cardiac conduction protein stabilization positive regulation of potassium ion import across plasma membrane cellular calcium ion homeostasis ion transport cellular potassium ion homeostasis potassium ion transport membrane repolarization ion transmembrane transport ATP metabolic process cell adhesion regulation of gene expression positive regulation of calcium:sodium antiporter activity protein localization to plasma membrane membrane repolarization during cardiac muscle cell action potential relaxation of cardiac muscle regulation of calcium ion transmembrane transport leukocyte migration positive regulation of potassium ion transmembrane transporter activity protein transport into plasma membrane raft potassium ion import across plasma membrane establishment or maintenance of transmembrane electrochemical gradient transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 481 11931 Ensembl ENSG00000143153 ENSMUSG00000026576 UniProt P05026 P14094 RefSeq (mRNA) NM_001677 NM_001001787 NM_009721 RefSeq (protein) NP_001668 NP_033851 Location (UCSC) Chr 1: 169.11 – 169.31 Mb Chr 1: 164.26 – 164.29 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Sodium/potassium-transporting ATPase subunit beta-1is anenzymethat in humans is encoded by theATP1B1gene.

The protein encoded by this gene belongs to the family of Na⁺/K⁺and H⁺/K⁺ATPases beta chain proteins, and to the subfamily of Na⁺/K⁺-ATPases. Na⁺/K⁺-ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transportof a variety of organic and inorganic molecules, and forelectrical excitabilityof nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na⁺/K⁺-ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Lingrel JB, Orlowski J, Shull MM, Price EM (1990). "Molecular genetics of Na,K-ATPase".Prog. Nucleic Acid Res. Mol. Biol.Progress in Nucleic Acid Research and Molecular Biology.38:37–89.doi:10.1016/S0079-6603(08)60708-4.ISBN978-0-12-540038-1.PMID2158121.
• Oakey RJ, Watson ML, Seldin MF (1993). "Construction of a physical map on mouse and human chromosome 1: comparison of 13 Mb of mouse and 11 Mb of human DNA".Hum. Mol. Genet.1(8): 613–20.doi:10.1093/hmg/1.8.613.PMID1301170.
• Martin-Vasallo P, Dackowski W, Emanuel JR, Levenson R (1989)."Identification of a putative isoform of the Na,K-ATPase beta subunit. Primary structure and tissue-specific expression".J. Biol. Chem.264(8): 4613–8.doi:10.1016/S0021-9258(18)83787-5.PMID2538450.
• Ushkaryov YuA, Monastyrskaya GS, Broude NE, et al. (1990). "Human Na⁺,K⁺-ATPase genes. Beta-subunit gene family contains at least one gene and one pseudogene ".FEBS Lett.257(2): 439–42.doi:10.1016/0014-5793(89)81591-1.PMID2555225.S2CID13623201.
• Lane LK, Shull MM, Whitmer KR, Lingrel JB (1990). "Characterization of two genes for the human Na,K-ATPase beta subunit".Genomics.5(3): 445–53.doi:10.1016/0888-7543(89)90008-6.PMID2559024.
• Yang-Feng TL, Schneider JW, Lindgren V, et al. (1988). "Chromosomal localization of human Na⁺,K⁺-ATPase alpha- and beta-subunit genes ".Genomics.2(2): 128–38.doi:10.1016/0888-7543(88)90094-8.PMID2842249.
• Sverdlov ED, Broude NE, Sverdlov VE, et al. (1987). "Family of Na⁺,K⁺-ATPase genes. Intra-individual tissue-specific restriction fragment length polymorphism ".FEBS Lett.221(1): 129–33.doi:10.1016/0014-5793(87)80366-6.PMID2887455.S2CID32756405.
• Kawakami K, Nojima H, Ohta T, Nagano K (1986)."Molecular cloning and sequence analysis of human Na,K-ATPase beta-subunit".Nucleic Acids Res.14(7): 2833–44.doi:10.1093/nar/14.7.2833.PMC339706.PMID3008098.
• Coca-Prados M, Fernández-Cabezudo MJ, Sánchez-Torres J, et al. (1996). "Cell-specific expression of the human Na⁺,K⁺-ATPase beta 2 subunit isoform in the nonpigmented ciliary epithelium ".Invest. Ophthalmol. Vis. Sci.36(13): 2717–28.PMID7499094.
• Ruiz A, Bhat SP, Bok D (1995). "Characterization and quantification of full-length and truncated Na,K-ATPase alpha 1 and beta 1 RNA transcripts expressed in human retinal pigment epithelium".Gene.155(2): 179–84.doi:10.1016/0378-1119(94)00812-7.PMID7536695.
• Mobasheri A, Oukrif D, Dawodu SP, et al. (2001). "Isoforms of Na⁺,K⁺-ATPase in human prostate; specificity of expression and apical membrane polarization ".Histol. Histopathol.16(1): 141–54.PMID11193188.
• Gamaleĭ IA, Polozov IuS, Aksenov ND, et al. (2001). "[Cell cycle and formation of active form of oxygen in rodent fibroblasts]".Tsitologiia.43(6): 602–12.PMID11534180.
• Béguin P, Crambert G, Monnet-Tschudi F, et al. (2002)."FXYD7 is a brain-specific regulator of Na,K-ATPase α1–β isozymes".EMBO J.21(13): 3264–73.doi:10.1093/emboj/cdf330.PMC125393.PMID12093728.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry".Nat. Biotechnol.21(6): 660–6.doi:10.1038/nbt827.PMID12754519.S2CID581283.
• Fuller W, Eaton P, Bell JR, Shattock MJ (2004)."Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase".FASEB J.18(1): 197–9.doi:10.1096/fj.03-0213fje.PMID14597563.S2CID41768501.
• Li J, Codina J, Petroske E, et al. (2004)."The carboxy terminus of the colonic H⁺,K⁺-ATPase alpha-subunit is required for stable beta subunit assembly and function ".Kidney Int.65(4): 1301–10.doi:10.1111/j.1523-1755.2004.00507.x.PMID15086469.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Wickham L, Benjannet S, Marcinkiewicz E, et al. (2005)."Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin".J. Neurochem.92(1): 93–102.doi:10.1111/j.1471-4159.2004.02840.x.PMID15606899.

External links

• HumanATP1B1genome location andATP1B1gene details page in theUCSC Genome Browser.