ATP2A3

ATP2A3
Identifiers
Aliases	ATP2A3,SERCA3, ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
External IDs	OMIM:601929;MGI:1194503;HomoloGene:69131;GeneCards:ATP2A3;OMA:ATP2A3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17p13.2 Start 3,923,870bp End 3,964,464bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B4 Start 72,851,995bp End 72,883,870bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in granulocyte olfactory zone of nasal mucosa spleen mucosa of transverse colon thymus lymph node blood bone marrow cells beta cell appendix Top expressed in submandibular gland parotid gland granulocyte islet of Langerhans pyloric antrum crypt of lieberkuhn of small intestine colon left colon thymus tibiofemoral joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding P-type calcium transporter activity metal ion binding hydrolase activity ATP binding P-type proton-exporting transporter activity Cellular component integral component of membrane nuclear membrane endoplasmic reticulum membrane membrane sarcoplasmic reticulum platelet dense tubular network membrane endoplasmic reticulum nucleus sarcoplasmic reticulum membrane Biological process regulation of cardiac conduction ion transport ion transmembrane transport calcium ion transmembrane transport calcium ion transport cellular calcium ion homeostasis proton transmembrane transport Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 489 53313 Ensembl ENSG00000074370 ENSMUSG00000020788 UniProt Q93084 Q64518 RefSeq (mRNA) NM_005173 NM_174953 NM_174954 NM_174955 NM_174956 NM_174957 NM_174958 NM_001163336 NM_001163337 NM_016745 RefSeq (protein) NP_005164 NP_777613 NP_777614 NP_777615 NP_777616 NP_777617 NP_777618 NP_001156808 NP_001156809 NP_058025 Location (UCSC) Chr 17: 3.92 – 3.96 Mb Chr 11: 72.85 – 72.88 Mb PubMedsearch
Wikidata
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Sarcoplasmic/endoplasmic reticulum calcium ATPase 3is anenzymethat inhumansis encoded by theATP2A3gene.

This gene encodes one of the SERCA Ca²⁺-ATPases, which are intracellular pumps located in thesarcoplasmicorendoplasmic reticulaof cells. SERCA3 expression was originally described as non-muscular, but was recently observed incardiomyocyte.This enzyme catalyzes the hydrolysis of ATP coupled with the translocation ofcalciumfrom thecytosolto the sarcoplasmic reticulumlumen,and is involved in calcium sequestration associated with muscular excitation and contraction. Alternative splicing results in 6 transcript variants encoding different isoforms named SERCA3a to SERCA3f.

Cancer

ATP2A3 gene has been observed progressively downregulated inHuman papillomavirus-positiveneoplastic keratinocytesderived from uterine cervicalpreneoplastic lesionsat different levels of malignancy.For this reason, ATP2A3 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervicalpreneoplastic lesionsprogression.

External links

• HumanATP2A3genome location andATP2A3gene details page in theUCSC Genome Browser.

Further reading

• Wuytack F, Papp B, Verboomen H, et al. (1994)."A sarco/endoplasmic reticulum Ca²⁺-ATPase 3-type Ca²⁺pump is expressed in platelets, in lymphoid cells, and in mast cells ".J. Biol. Chem.269(2): 1410–6.doi:10.1016/S0021-9258(17)42273-3.PMID8288608.
• Dode L, De Greef C, Mountain I, et al. (1998)."Structure of the human sarco/endoplasmic reticulum Ca²⁺-ATPase 3 gene. Promoter analysis and alternative splicing of the SERCA3 pre-mRNA ".J. Biol. Chem.273(22): 13982–94.doi:10.1074/jbc.273.22.13982.PMID9593748.
• Poch E, Leach S, Snape S, et al. (1999)."Functional characterization of alternatively spliced human SERCA3 transcripts".Am. J. Physiol.275(6 Pt 1): C1449–58.doi:10.1152/ajpcell.1998.275.6.C1449.PMID9843705.
• Martin V, Bredoux R, Corvazier E, et al. (2002)."Three novel sarco/endoplasmic reticulum Ca²⁺-ATPase (SERCA) 3 isoforms. Expression, regulation, and function of the membranes of the SERCA3 family ".J. Biol. Chem.277(27): 24442–52.doi:10.1074/jbc.M202011200.PMID11956212.
• Gélébart P, Kovács T, Brouland JP, et al. (2002)."Expression of endomembrane calcium pumps in colon and gastric cancer cells. Induction of SERCA3 expression during differentiation".J. Biol. Chem.277(29): 26310–20.doi:10.1074/jbc.M201747200.PMID11986315.
• Dode L, Vilsen B, Van Baelen K, et al. (2003)."Dissection of the functional differences between sarco(endo)plasmic reticulum Ca²⁺-ATPase (SERCA) 1 and 3 isoforms by steady-state and transient kinetic analyses ".J. Biol. Chem.277(47): 45579–91.doi:10.1074/jbc.M207778200.PMID12207029.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Houston R (2003). "Longitudinal sections of unfixed muscle".Biotechnic & Histochemistry.77(4): 229–30.PMID12503734.
• Borge PD, Wolf BA (2003)."Insulin receptor substrate 1 regulation of sarco-endoplasmic reticulum calcium ATPase 3 in insulin-secreting beta-cells".J. Biol. Chem.278(13): 11359–68.doi:10.1074/jbc.M209521200.PMID12524443.
• Chandrasekera CP, Lytton J (2003)."Inhibition of human SERCA3 by PL/IM430. Molecular analysis of the interaction".J. Biol. Chem.278(14): 12482–8.doi:10.1074/jbc.M212745200.PMID12540840.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides".Nat. Biotechnol.21(5): 566–9.doi:10.1038/nbt810.PMID12665801.S2CID23783563.
• Bobe R, Bredoux R, Corvazier E, et al. (2004)."Identification, expression, function, and localization of a novel (sixth) isoform of the human sarco/endoplasmic reticulum Ca²⁺ATPase 3 gene ".J. Biol. Chem.279(23): 24297–306.doi:10.1074/jbc.M314286200.PMID15028735.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Brouland JP, Gélébart P, Kovàcs T, et al. (2005)."The loss of sarco/endoplasmic reticulum calcium transport ATPase 3 expression is an early event during the multistep process of colon carcinogenesis".Am. J. Pathol.167(1): 233–42.doi:10.1016/S0002-9440(10)62968-9.PMC1603437.PMID15972967.
• Hadri L, Pavoine C, Lipskaia L, et al. (2006)."Transcription of the sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase type 3 gene, ATP2A3, is regulated by the calcineurin/NFAT pathway in endothelial cells ".Biochem. J.394(Pt 1): 27–33.doi:10.1042/BJ20051387.PMC1385999.PMID16250893.
• Wootton LL, Michelangeli F (2006)."The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca²⁺ATPase (SERCA) Ca²⁺pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors ".J. Biol. Chem.281(11): 6970–6.doi:10.1074/jbc.M510978200.PMID16410239.
• Chaâbane C, Corvazier E, Bredoux R, et al. (2006). "Sarco/endoplasmic reticulum Ca²⁺ATPase type 3 isoforms (SERCA3b and SERCA3f): distinct roles in cell adhesion and ER stress ".Biochem. Biophys. Res. Commun.345(4): 1377–85.doi:10.1016/j.bbrc.2006.05.054.PMID16725111.
• Bredoux R, Corvazier E, Dally S, et al. (2006). "Human platelet Ca²⁺-ATPases: new markers of cell differentiation as illustrated in idiopathic scoliosis ".Platelets.17(6): 421–33.doi:10.1080/09537100600758719.PMID16973504.S2CID24473757.
• Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.