ATP2B1
Plasma membrane calcium-transporting ATPase 1also known asPlasma membrane calcium pump isoform 1is aplasma membraneCa2+
ATPase,anenzymethat in humans is encoded by theATP2B1gene.[5][6]It's atransport protein,atranslocase,acalcium pumpEC7.2.2.10.
The protein encoded by this gene belongs to the family ofP-type primary ion transport ATPasescharacterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellularcalcium homeostasis.The mammalianplasma membranecalcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased byalternative splicingof transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues.[6]
Clinical significance
[edit]ATP2B1 is a critical host factor supportingcytotoxicitycaused byChironex fleckeri(a type ofbox jellyfish) stings. Blocking ATP2B1 is believed to have therapeutic potential for treating pain and skin necrosis caused by these stings.[7]
Mutations of the ATP2B1 gene cause a neurodevelopmental delay with mild to moderately impaired intellectual development and mild speech delay.[8]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000070961–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000019943–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Olson S, Wang MG, Carafoli E, Strehler EE, McBride OW (April 1991). "Localization of two genes encoding plasma membrane Ca2(+)-transporting ATPases to human chromosomes 1q25-32 and 12q21-23".Genomics.9(4): 629–41.doi:10.1016/0888-7543(91)90356-J.PMID1674727.
- ^ab"Entrez Gene: ATP2B1 ATPase, Ca++ transporting, plasma membrane 1".
- ^Lau MT, Manion J, Littleboy JB, Oyston L, Khuong TM, Wang QP, Nguyen DT, Hesselson D, Seymour JE, Neely GG (April 2019)."Molecular dissection of box jellyfish venom cytotoxicity highlights an effective venom antidote".Nature Communications.10(1): 1655.Bibcode:2019NatCo..10.1655L.doi:10.1038/s41467-019-09681-1.PMC6491561.PMID31040274.
- ^Rahimi MJ, Urban N, Wegler M, Sticht H, Schaefer M, Popp B, Gaunitz F, Morleo M, Nigro V, Maitz S, Mancini GM, Ruivenkamp C, Suk EK, Bartolomaeus T, Merkenschlager A, Koboldt D, Bartholomew D, Stegmann AP, Sinnema M, Duynisveld I, Salvarinova R, Race S, de Vries BB, Trimouille A, Naudion S, Marom D, Hamiel U, Henig N, Demurger F, Rahner N, Bartels E, Hamm JA, Putnam AM, Person R, Abou Jamra R, Oppermann H (May 2022)."De novo variants in ATP2B1 lead to neurodevelopmental delay".American Journal of Human Genetics.109(5): 944–952.doi:10.1016/j.ajhg.2022.03.009.PMC9118097.PMID35358416.
External links
[edit]- HumanATP2B1genome location andATP2B1gene details page in theUCSC Genome Browser.
Further reading
[edit]- Møller JV, Juul B, le Maire M (May 1996). "Structural organization, ion transport, and energy transduction of P-type ATPases".Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes.1286(1): 1–51.doi:10.1016/0304-4157(95)00017-8.PMID8634322.
- Strehler EE, Zacharias DA (January 2001). "Role of alternative splicing in generating isoform diversity among plasma membrane calcium pumps".Physiological Reviews.81(1): 21–50.doi:10.1152/physrev.2001.81.1.21.PMID11152753.S2CID9062253.
- Strehler EE, Treiman M (May 2004). "Calcium pumps of plasma membrane and cell interior".Current Molecular Medicine.4(3): 323–35.doi:10.2174/1566524043360735.PMID15101689.
- Kessler F, Falchetto R, Heim R, Meili R, Vorherr T, Strehler EE, Carafoli E (December 1992). "Study of calmodulin binding to the alternatively spliced C-terminal domain of the plasma membrane Ca2+ pump".Biochemistry.31(47): 11785–92.doi:10.1021/bi00162a016.PMID1332771.
- Wang KK, Wright LC, Machan CL, Allen BG, Conigrave AD, Roufogalis BD (May 1991)."Protein kinase C phosphorylates the carboxyl terminus of the plasma membrane Ca(2+)-ATPase from human erythrocytes".The Journal of Biological Chemistry.266(14): 9078–85.doi:10.1016/S0021-9258(18)31554-0.PMID1827443.
- Strehler EE, Strehler-Page MA, Vogel G, Carafoli E (September 1989)."mRNAs for plasma membrane calcium pump isoforms differing in their regulatory domain are generated by alternative splicing that involves two internal donor sites in a single exon".Proceedings of the National Academy of Sciences of the United States of America.86(18): 6908–12.Bibcode:1989PNAS...86.6908S.doi:10.1073/pnas.86.18.6908.PMC297959.PMID2528729.
- James PH, Pruschy M, Vorherr TE, Penniston JT, Carafoli E (May 1989). "Primary structure of the cAMP-dependent phosphorylation site of the plasma membrane calcium pump".Biochemistry.28(10): 4253–8.doi:10.1021/bi00436a020.PMID2548572.
- Verma AK, Filoteo AG, Stanford DR, Wieben ED, Penniston JT, Strehler EE, Fischer R, Heim R, Vogel G, Mathews S (October 1988)."Complete primary structure of a human plasma membrane Ca2+ pump".The Journal of Biological Chemistry.263(28): 14152–9.doi:10.1016/S0021-9258(18)68198-0.PMID2844759.
- Howard A, Legon S, Walters JR (November 1993). "Human and rat intestinal plasma membrane calcium pump isoforms".The American Journal of Physiology.265(5 Pt 1): G917-25.doi:10.1152/ajpgi.1993.265.5.G917.PMID7694502.
- Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (December 1993)."Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes".The Journal of Biological Chemistry.268(34): 25993–6003.doi:10.1016/S0021-9258(19)74484-6.PMID8245032.
- Stauffer TP, Hilfiker H, Carafoli E, Strehler EE (December 1994)."Quantitative analysis of alternative splicing options of human plasma membrane calcium pump genes".The Journal of Biological Chemistry.269(50): 32022.doi:10.1016/S0021-9258(18)31797-6.PMID7989379.
- Kumar R, Haugen JD, Penniston JT (April 1993). "Molecular cloning of a plasma membrane calcium pump from human osteoblasts".Journal of Bone and Mineral Research.8(4): 505–13.doi:10.1002/jbmr.5650080415.PMID8386431.S2CID43674131.
- Hilfiker H, Strehler-Page MA, Stauffer TP, Carafoli E, Strehler EE (September 1993)."Structure of the gene encoding the human plasma membrane calcium pump isoform 1".The Journal of Biological Chemistry.268(26): 19717–25.doi:10.1016/S0021-9258(19)36574-3.PMID8396145.
- Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A" double adaptor "method for improved shotgun library construction".Analytical Biochemistry.236(1): 107–13.doi:10.1006/abio.1996.0138.PMID8619474.
- Bonaldo MF, Lennon G, Soares MB (September 1996)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Research.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID8889548.
- Benkwitz C, Kubisch C, Kraft K, Neyses L (January 1997). "Investigation of the Met-267 Arg exchange in isoform 1 of the human plasma membrane calcium pump in patients with essential hypertension by the amplification-created restriction site technique".Journal of Molecular Medicine.75(1): 62–6.doi:10.1007/s001090050088.PMID9020386.S2CID7041799.
- Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997)."Large-scale concatenation cDNA sequencing".Genome Research.7(4): 353–8.doi:10.1101/gr.7.4.353.PMC139146.PMID9110174.
- Elshorst B, Hennig M, Försterling H, Diener A, Maurer M, Schulte P, Schwalbe H, Griesinger C, Krebs J, Schmid H, Vorherr T, Carafoli E (September 1999). "NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump".Biochemistry.38(38): 12320–32.doi:10.1021/bi9908235.PMID10493800.S2CID24440343.