Aglepristone

Aglepristone
Clinical data
Trade names	Alizin
Other names	RU-46534; RU-534; 11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17α-[(Z)-propenyl]estra-4,9-dien-3-one
Drug class	Antiprogestogen;Antiglucocorticoid
ATC code	G03XB90(WHO);
Identifiers
	IUPAC name (8S,11R,13S,14S,17R)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-[(Z)-prop-1-enyl]-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one;
CAS Number	124478-60-0;
PubChemCID	14153279;
ChemSpider	16736563;
UNII	0UT4JLE1CM;
KEGG	D07096;
ChEMBL	ChEMBL2103998;
CompTox Dashboard(EPA)	DTXSID001016632;
ECHA InfoCard	100.211.372
Chemical and physical data
Formula	C29H37NO2
Molar mass	431.620g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C/C=C\[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O;
	InChI InChI=1S/C29H37NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h5-7,9-10,15,17,24-26,32H,8,11-14,16,18H2,1-4H3/b15-5-/t24-,25+,26-,28-,29-/m0/s1; Key:RTCKAOKDXNYXEH-FWSJOHTJSA-N;

Aglepristone(INNTooltip International Nonproprietary Name) (brand nameAlizin;former developmental code namesRU-46534,RU-534) is asynthetic,steroidal antiprogestogenrelated tomifepristonewhich is marketed byVirbacin severalEuropeancountries for use inveterinary medicine.^[1]^[2]^[3]It is specifically used as anabortifacientinpregnantanimals.^[1]^[3]^[4]Aglepristone, similarly to mifepristone, also possesses someantiglucocorticoidactivity.^[5]^[6]

References

^^a ^bKaufman LK, Baldwin CJ (1 December 2013)."Pregnancy Loss in the Bitch and Queen".In Bonagura JD, Twedt DC (eds.).Kirk's Current Veterinary Therapy XV.Elsevier Health Sciences. pp. 3009–.ISBN 978-0-323-22762-9.
^Squires EJ (2010)."Endocrine manipulation of reproduction.".Applied Animal Endocrinology.CABI. pp. 207–.ISBN 978-1-84593-755-3.
^^a ^bPapich MC (3 November 2010)."Aglepristone".Saunders Handbook of Veterinary Drugs: Small and Large Animal.Elsevier Health Sciences. pp. 120–.ISBN 978-1-4377-0192-0.
^Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001). Concannon PW (ed.). "Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)".Journal of Reproduction and Fertility. Supplement.Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000.57:243–8.ISBN 978-0-906545-37-9.PMID 11787157.
^Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat".Reproduction in Domestic Animals = Zuchthygiene.46(5): 882–888.doi:10.1111/j.1439-0531.2011.01759.x.PMID 21320179.
^Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs".Theriogenology.69(4): 399–407.doi:10.1016/j.theriogenology.2007.10.008.PMID 18054071.

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[BonaguraTwedt2013-1] Kaufman LK, Baldwin CJ (1 December 2013)."Pregnancy Loss in the Bitch and Queen".In Bonagura JD, Twedt DC (eds.).Kirk's Current Veterinary Therapy XV.Elsevier Health Sciences. pp. 3009–.ISBN 978-0-323-22762-9.

[Squires2010-2] Squires EJ (2010)."Endocrine manipulation of reproduction.".Applied Animal Endocrinology.CABI. pp. 207–.ISBN 978-1-84593-755-3.

[Papich2010-3] Papich MC (3 November 2010)."Aglepristone".Saunders Handbook of Veterinary Drugs: Small and Large Animal.Elsevier Health Sciences. pp. 120–.ISBN 978-1-4377-0192-0.

[Concannon2001-4] Fieni F, Martal J, Marnet PG, Siliart B, Bernard F, Riou M, Bruyas JF, Tainturier D (2001). Concannon PW (ed.). "Hormonal variation in bitches after early or mid-pregnancy termination with aglepristone (RU534)".Journal of Reproduction and Fertility. Supplement.Advances in reproduction in dogs, cats and exotic carnivores: proceedings of the fourth International Symposium on Canine and Feline Reproduction, Oslo, Norway, 29 June-1 July 2000.57:243–8.ISBN 978-0-906545-37-9.PMID 11787157.

[pmid21320179-5] Batista M, Reyes R, Santana M, Alamo D, Vilar J, González F, et al. (October 2011). "Induction of parturition with aglepristone in the Majorera goat".Reproduction in Domestic Animals = Zuchthygiene.46(5): 882–888.doi:10.1111/j.1439-0531.2011.01759.x.PMID 21320179.

[pmid18054071-6] Baan M, Taverne MA, de Gier J, Kooistra HS, Kindahl H, Dieleman SJ, Okkens AC (March 2008). "Hormonal changes in spontaneous and aglépristone-induced parturition in dogs".Theriogenology.69(4): 399–407.doi:10.1016/j.theriogenology.2007.10.008.PMID 18054071.

[1]

[2]

[3]

[4]

[5]

[6]

v t e Other sex hormones and modulators of the genital system (G03X)
Antigonadotropins(G03XA)	Danazol Gestrinone Anti-Pmsg
Antiprogestogens(G03XB)	Mifepristone Ulipristal Aglepristone
Selective estrogen receptor modulators(G03XC)	Raloxifene Bazedoxifene Lasofoxifene Ormeloxifene Ospemifene
Others (G03XX)	Prasterone

See also

References