Alprazolam triazolobenzophenone
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Formula | C17H15ClN4O |
Molar mass | 326.78g·mol−1 |
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Alprazolam triazolobenzophenoneis a chemical compound that is aprodrugfor thebenzodiazepinederivativealprazolam.At neutral pH it readily cyclizes to alprazolam, while in acidic conditions alprazolam undergoes a ring-opening reaction back to the ketone. A series of relatedacylderivatives was researched in the 1980s as injectable water-soluble prodrugs of alprazolam,[1]but were never developed for medical use. Subsequently, this compound has been detected as adesigner drug,first being identified from a seizure in Spain in March 2014.[2]
See also
[edit]References
[edit]- ^Cho MJ, Sethy VH, Haynes LC (August 1986). "Sequentially labile water-soluble prodrugs of alprazolam".Journal of Medicinal Chemistry.29(8): 1346–50.doi:10.1021/jm00158a004.PMID3016261.
- ^"Novel Benzodiazepines. A review of the evidence of use and harms of Novel Benzodiazepines"(PDF).Advisory Council on the Misuse of Drugs. April 2020.