BCCIP
BRCA2 and CDKN1A-interacting proteinis aproteinthat is encoded by theBCCIPgenein humans.[5][6][7]
This gene product was isolated based on its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. Several transcript variants encoding different isoforms have been described for this gene.[7]
Interactions
[edit]BCCIP has been shown tointeractwithBRCA2,[5]P21,[6]and PTPmu (PTPRM)[8]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000107949–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000030983–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^abLiu J, Yuan Y, Huan J, Shen Z (Apr 2001)."Inhibition of breast and brain cancer cell growth by BCCIPalpha, an evolutionarily conserved nuclear protein that interacts with BRCA2".Oncogene.20(3): 336–45.doi:10.1038/sj.onc.1204098.PMID11313963.
- ^abOno T, Kitaura H, Ugai H, Murata T, Yokoyama KK, Iguchi-Ariga SM, Ariga H (Oct 2000)."TOK-1, a novel p21Cip1-binding protein that cooperatively enhances p21-dependent inhibitory activity toward CDK2 kinase".J Biol Chem.275(40): 31145–54.doi:10.1074/jbc.M003031200.PMID10878006.
- ^ab"Entrez Gene: BCCIP BRCA2 and CDKN1A interacting protein".
- ^Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM (2008)."BCCIP associates with the receptor protein tyrosine phosphatase PTPmu".J Cell Biochem.105(4): 1059–72.doi:10.1002/jcb.21907.PMC2758318.PMID18773424.
External links
[edit]- HumanBCCIPgenome location andBCCIPgene details page in theUCSC Genome Browser.
Further reading
[edit]- Coleman RA, Rao P, Fogelsong RJ, Bardes ES (1992). "2-Bromopalmitoyl-CoA and 2-bromopalmitate: promiscuous inhibitors of membrane-bound enzymes".Biochim. Biophys. Acta.1125(2): 203–9.doi:10.1016/0005-2760(92)90046-X.PMID1571364.
- Machackova E, Damborsky J, Valik D, Foretova L (2002)."Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic".Hum. Mutat.18(6): 545.doi:10.1002/humu.1232.PMID11748848.S2CID8549550.
- Armakolas A, Ladopoulou A, Konstantopoulou I, et al. (2002)."BRCA2 gene mutations in Greek patients with familial breast cancer".Hum. Mutat.19(1): 81–2.doi:10.1002/humu.9003.PMID11754111.S2CID25598124.
- Robson M, Scheuer L, Nafa K, et al. (2002)."Unique de novo mutation of BRCA2 in a woman with early onset breast cancer".J. Med. Genet.39(2): 126–8.doi:10.1136/jmg.39.2.126.PMC1735025.PMID11836363.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Meng X, Liu J, Shen Z (2003). "Genomic structure of the human BCCIP gene and its expression in cancer".Gene.302(1–2): 139–46.doi:10.1016/S0378-1119(02)01098-3.PMID12527204.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Meng X, Liu J, Shen Z (2004)."Inhibition of G1 to S cell cycle progression by BCCIP beta".Cell Cycle.3(3): 343–8.doi:10.4161/cc.3.3.672.PMID14726710.
- Deloukas P, Earthrowl ME, Grafham DV, et al. (2004)."The DNA sequence and comparative analysis of human chromosome 10".Nature.429(6990): 375–81.Bibcode:2004Natur.429..375D.doi:10.1038/nature02462.PMID15164054.
- Colland F, Jacq X, Trouplin V, et al. (2004)."Functional proteomics mapping of a human signaling pathway".Genome Res.14(7): 1324–32.doi:10.1101/gr.2334104.PMC442148.PMID15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Meng X, Lu H, Shen Z (2007)."BCCIP functions through p53 to regulate the expression of p21Waf1/Cip1".Cell Cycle.3(11): 1457–62.doi:10.4161/cc.3.11.1213.PMID15539944.
- Lu H, Guo X, Meng X, et al. (2005)."The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair".Mol. Cell. Biol.25(5): 1949–57.doi:10.1128/MCB.25.5.1949-1957.2005.PMC549367.PMID15713648.
- Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome".Cell.122(6): 957–68.doi:10.1016/j.cell.2005.08.029.hdl:11858/00-001M-0000-0010-8592-0.PMID16169070.S2CID8235923.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
- Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID17081983.S2CID7827573.
- Meng X, Yue J, Liu Z, Shen Z (2007)."Abrogation of the transactivation activity of p53 by BCCIP down-regulation".J. Biol. Chem.282(3): 1570–6.doi:10.1074/jbc.M607520200.PMC2679999.PMID17135243.
- Ewing RM, Chu P, Elisma F, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Mol. Syst. Biol.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.
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