Beta-ureidopropionase
| beta-ureidopropionase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.5.1.6 | ||||||||
| CAS no. | 9027-27-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDBstructures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO/QuickGO | ||||||||
| |||||||||
Inenzymology,abeta-ureidopropionase(EC3.5.1.6) is anenzymethatcatalyzesthechemical reaction
- N-carbamoyl-beta-alanine + H2Obeta-alanine + CO2+ NH3
Thus, the twosubstratesof this enzyme areN-carbamoyl-beta-alanineandH2O,whereas its 3productsarebeta-alanine,CO2,andNH3.
This enzyme belongs to the family ofhydrolases,those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. Thesystematic nameof this enzyme class isN-carbamoyl-beta-alanine amidohydrolase.This enzyme participates in 3metabolic pathways:pyrimidine metabolism,beta-alanine metabolism,andpantothenateandcoenzyme Abiosynthesis.
Structural studies
[edit]As of late 2007, 6structureshave been solved for this class of enzymes, withPDBaccession codes1R3N,1R43,2V8D,2V8G,2V8H,and2V8V.
References
[edit]- CAMPBELL LL (1960)."Reductive degradation of pyrimidines. 5. Enzymatic conversion of N-carbamyl-beta-alanine to beta-alanine, carbon dioxide, and ammonia".J. Biol. Chem.235:2375–8.doi:10.1016/S0021-9258(18)64630-7.PMID13849303.
- CARAVACA J, GRISOLIA S (1958)."Enzymatic decarbamylation of carbamyl beta-alanine and carbamyl beta-aminoisobutyric acid".J. Biol. Chem.231(1): 357–65.doi:10.1016/S0021-9258(19)77312-8.PMID13538975.
- Traut TW, Loechel S (1984). "Pyrimidine catabolism: individual characterization of the three sequential enzymes with a new assay".Biochemistry.23(11): 2533–9.doi:10.1021/bi00306a033.PMID6433973.
