CA11

For theU.S. federal circuit court of appeals,seeUnited States Court of Appeals for the Eleventh Circuit.For the highway, seeCalifornia State Route 11.For the congressional district, seeCalifornia's 11th congressional district.

CA11
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 2W2J
Identifiers
Aliases	CA11,CARPX1, carbonic anhydrase 11, CA-RP II, CA-RP, CARP-2, CA-XI
External IDs	OMIM:604644;MGI:1336193;HomoloGene:36061;GeneCards:CA11;OMA:CA11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 48,637,946bp End 48,646,187bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 45,349,267bp End 45,354,106bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe nucleus accumbens amygdala caudate nucleus dorsolateral prefrontal cortex Brodmann area 9 prefrontal cortex cingulate gyrus anterior cingulate cortex Top expressed in superior frontal gyrus primary visual cortex olfactory tubercle nucleus accumbens dentate gyrus of hippocampal formation granule cell piriform cortex globus pallidus Region I of hippocampus proper prefrontal cortex primary motor cortex More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 770 12348 Ensembl ENSG00000063180 ENSMUSG00000003273 UniProt O75493 O70354 RefSeq (mRNA) NM_001217 NM_009800 NM_001368349 RefSeq (protein) NP_001208 NP_033930 NP_001355278 Location (UCSC) Chr 19: 48.64 – 48.65 Mb Chr 7: 45.35 – 45.35 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Carbonic anhydrase-related protein 11is aproteinthat in humans is encoded by theCA11gene.

Function

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XI is likely a secreted protein, however, radical changes at active site residues completely conserved in CA isozymes with catalytic activity, make it unlikely that it has carbonic anhydrase activity. It shares properties in common with two other acatalytic CA isoforms, CA VIII and CA X. CA XI is most abundantly expressed in brain, and may play a general role in the central nervous system.

Interactions

CA11 has been shown tointeractwithRIPK1.

Further reading

• Bellingham J, Gregory-Evans K, Gregory-Evans CY (1998). "Sequence and tissue expression of a novel human carbonic anhydrase-related protein, CARP-2, mapping to chromosome 19q13.3".Biochem. Biophys. Res. Commun.253(2): 364–7.doi:10.1006/bbrc.1998.9449.PMID9878543.
• Fujikawa-Adachi K, Nishimori I, Taguchi T, Yuri K, Onishi S (1999). "cDNA sequence, mRNA expression, and chromosomal localization of human carbonic anhydrase-related protein, CA-RP XI".Biochim. Biophys. Acta.1431(2): 518–24.doi:10.1016/S0167-4838(99)00067-9.PMID10350627.
• Okamoto N, Fujikawa-Adachi K, Nishimori I, Taniuchi K, Onishi S (2001). "cDNA sequence of human carbonic anhydrase-related protein, CA-RP X: mRNA expressions of CA-RP X and XI in human brain".Biochim. Biophys. Acta.1518(3): 311–6.doi:10.1016/s0167-4781(01)00193-2.PMID11311946.
• Taniuchi K, Nishimori I, Takeuchi T, Fujikawa-Adachi K, Ohtsuki Y, Onishi S (2002). "Developmental expression of carbonic anhydrase-related proteins VIII, X, and XI in the human brain".Neuroscience.112(1): 93–9.doi:10.1016/S0306-4522(02)00066-0.PMID12044474.S2CID31186391.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006)."Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry".J. Proteome Res.4(6): 2070–80.doi:10.1021/pr0502065.PMC1850943.PMID16335952.

External links

• HumanCA11genome location andCA11gene details page in theUCSC Genome Browser.