CALM2
Calmodulin 2is aproteinthat in humans is encoded by theCALM2gene.[3][4]A member of thecalmodulinfamily of signaling molecules, it is an intermediary between calcium ions, which act as asecond messenger,and many intracellular processes, such as the contraction ofcardiac muscle.[5]
Clinical significance[edit]
Mutations in CALM2 are associated withcardiac arrhythmias.[6]In particular, severalsingle-nucleotide polymorphismsof CALM2 have been reported as potential causes ofsudden infant death syndrome.Due to their heritability, CALM2 mutations can affect multiple children in a family,[7]and the discovery of the deadly consequences of these mutations has led to challenges against the murder convictions of mothers of multiple deceased infants, as in the case ofKathleen Folbigg,acquitted after more than 20 years imprisonment, in Australia.[8]
Interactions[edit]
CALM2 has been shown tointeractwithAKAP9.[9][10]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000143933–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Entrez Gene: CALM2 Calmodulin 2 (phosphorylase kinase, delta)".
- ^SenGupta B, Friedberg F, Detera-Wadleigh SD (December 1987)."Molecular analysis of human and rat calmodulin complementary DNA clones. Evidence for additional active genes in these species".The Journal of Biological Chemistry.262(34): 16663–16670.doi:10.1016/S0021-9258(18)49306-4.PMID2445749.
- ^"Entry - *114205 - CALCIUM CHANNEL, VOLTAGE-DEPENDENT, L TYPE, ALPHA-1C SUBUNIT; CACNA1C - OMIM".omim.org.Retrieved2023-06-01.
- ^Makita N, Yagihara N, Crotti L, Johnson CN, Beckmann BM, Roh MS, et al. (August 2014)."Novel calmodulin mutations associated with congenital arrhythmia susceptibility".Circulation: Cardiovascular Genetics.7(4): 466–474.doi:10.1161/CIRCGENETICS.113.000459.PMC4140998.PMID24917665.
- ^Brohus M, Arsov T, Wallace DA, Jensen HH, Nyegaard M, Crotti L, et al. (March 2021)."Infanticide vs. inherited cardiac arrhythmias".Europace.Volume 23, Issue 3.23(3). European Heart Rhythm Association (published 17 November 2020): 441–450.doi:10.1093/europace/euaa272.PMC7947592.PMID33200177.
- ^Schwartz O."4 Dead Infants, a Convicted Mother, and a Genetic Mystery".Wired.ISSN1059-1028.Retrieved2023-06-01.
- ^Takahashi M, Yamagiwa A, Nishimura T, Mukai H, Ono Y (September 2002)."Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex".Molecular Biology of the Cell.13(9): 3235–3245.doi:10.1091/mbc.E02-02-0112.PMC124155.PMID12221128.
- ^Berchtold MW, Egli R, Rhyner JA, Hameister H, Strehler EE (May 1993). "Localization of the human bona fide calmodulin genes CALM1, CALM2, and CALM3 to chromosomes 14q24-q31, 2p21.1-p21.3, and 19q13.2-q13.3".Genomics.16(2): 461–465.doi:10.1006/geno.1993.1211.PMID8314583.
External links[edit]
- HumanCALM2genome location andCALM2gene details page in theUCSC Genome Browser.
Further reading[edit]
- Zhang M, Yuan T (1998). "Molecular mechanisms of calmodulin's functional versatility".Biochemistry and Cell Biology.76(2–3): 313–323.doi:10.1139/bcb-76-2-3-313.PMID9923700.
- Gusev NB (October 2001). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation".Biochemistry. Biokhimiia.66(10): 1112–1121.doi:10.1023/A:1012480829618.PMID11736632.S2CID310781.
- Benaim G, Villalobo A (August 2002)."Phosphorylation of calmodulin. Functional implications".European Journal of Biochemistry.269(15): 3619–3631.doi:10.1046/j.1432-1033.2002.03038.x.hdl:10261/79981.PMID12153558.
- Koller M, Schnyder B, Strehler EE (October 1990). "Structural organization of the human CaMIII calmodulin gene".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1087(2): 180–189.doi:10.1016/0167-4781(90)90203-e.PMID2223880.
- Baudier J, Mochly-Rosen D, Newton A, Lee SH, Koshland DE, Cole RD (May 1987). "Comparison of S100b protein with calmodulin: interactions with melittin and microtubule-associated tau proteins and inhibition of phosphorylation of tau proteins by protein kinase C".Biochemistry.26(10): 2886–2893.doi:10.1021/bi00384a033.PMID3111527.
- Matoba R, Okubo K, Hori N, Fukushima A, Matsubara K (September 1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression".Gene.146(2): 199–207.doi:10.1016/0378-1119(94)90293-3.PMID8076819.
- Srinivas SK, Srinivas RV, Anantharamaiah GM, Compans RW, Segrest JP (October 1993)."Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins".The Journal of Biological Chemistry.268(30): 22895–22899.doi:10.1016/S0021-9258(18)41610-9.PMID8226798.
- Miller MA, Mietzner TA, Cloyd MW, Robey WG, Montelaro RC (November 1993). "Identification of a calmodulin-binding and inhibitory peptide domain in the HIV-1 transmembrane glycoprotein".AIDS Research and Human Retroviruses.9(11): 1057–1066.doi:10.1089/aid.1993.9.1057.PMID8312049.
- Radding W, Pan ZQ, Hunter E, Johnston P, Williams JP, McDonald JM (January 1996). "Expression of HIV-1 envelope glycoprotein alters cellular calmodulin".Biochemical and Biophysical Research Communications.218(1): 192–197.doi:10.1006/bbrc.1996.0034.PMID8573130.
- Pan Z, Radding W, Zhou T, Hunter E, Mountz J, McDonald JM (September 1996)."Role of calmodulin in HIV-potentiated Fas-mediated apoptosis".The American Journal of Pathology.149(3): 903–910.PMC1865159.PMID8780394.
- Sasaki M, Uchiyama J, Ishikawa H, Matsushita S, Kimura G, Nomoto K, Koga Y (October 1996)."Induction of apoptosis by calmodulin-dependent intracellular Ca2+ elevation in CD4+ cells expressing gp 160 of HIV".Virology.224(1): 18–24.doi:10.1006/viro.1996.0502.PMID8862395.
- Brigino E, Haraguchi S, Koutsonikolis A, Cianciolo GJ, Owens U, Good RA, Day NK (April 1997)."Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway".Proceedings of the National Academy of Sciences of the United States of America.94(7): 3178–3182.Bibcode:1997PNAS...94.3178B.doi:10.1073/pnas.94.7.3178.PMC20342.PMID9096366.
- Minakami R, Jinnai N, Sugiyama H (August 1997)."Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro".The Journal of Biological Chemistry.272(32): 20291–20298.doi:10.1074/jbc.272.32.20291.PMID9242710.
- Miyawaki A, Llopis J, Heim R, McCaffery JM, Adams JA, Ikura M, Tsien RY (August 1997)."Fluorescent indicators for Ca2+ based on green fluorescent proteins and calmodulin".Nature.388(6645): 882–887.doi:10.1038/42264.PMID9278050.S2CID13745050.
- Malvoisin E, Wild F (August 1997). "Inhibition of HIV-1, HIV-2 and SIV envelope glycoprotein-mediated cell fusion by calmodulin".Virus Research.50(2): 119–127.doi:10.1016/S0168-1702(97)00060-9.PMID9282777.
- Martoglio B, Graf R, Dobberstein B (November 1997)."Signal peptide fragments of preprolactin and HIV-1 p-gp160 interact with calmodulin".The EMBO Journal.16(22): 6636–6645.doi:10.1093/emboj/16.22.6636.PMC1170268.PMID9362478.
- Ishikawa H, Sasaki M, Noda S, Koga Y (August 1998)."Apoptosis induction by the binding of the carboxyl terminus of human immunodeficiency virus type 1 gp160 to calmodulin".Journal of Virology.72(8): 6574–6580.doi:10.1128/JVI.72.8.6574-6580.1998.PMC109834.PMID9658102.
- Toutenhoofd SL, Foletti D, Wicki R, Rhyner JA, Garcia F, Tolon R, Strehler EE (May 1998). "Characterization of the human CALM2 calmodulin gene and comparison of the transcriptional activity of CALM1, CALM2 and CALM3".Cell Calcium.23(5): 323–338.doi:10.1016/S0143-4160(98)90028-8.PMID9681195.