CAMK2D
Appearance
Calcium/calmodulin-dependent protein kinase type II delta chainis anenzymethat in humans is encoded by theCAMK2Dgene.[5]
The product of this gene belongs to theserine/threonine protein kinasefamily and to theCa2+/calmodulin-dependent protein kinasesubfamily.Calcium signalingis crucial for several aspects ofplasticityatglutamatergic synapses.In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Fouralternatively splicedtranscript variants that encode three differentisoformshave been characterized to date. Distinct isoforms of this chain have different expression patterns.[5]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000145349–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000053819–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: CAMK2D calcium/calmodulin-dependent protein kinase (CaM kinase) II delta".
Further reading
[edit]- Hook SS, Means AR (2001). "Ca2+/CaM-dependent kinases: from activation to function ".Annu. Rev. Pharmacol. Toxicol.41(1): 471–505.doi:10.1146/annurev.pharmtox.41.1.471.PMID11264466.
- Yamamoto H (2002). "[Molecular mechanisms of the intracellular localizations of Ca2+/calmodulin-dependent protein kinase II isoforms, and their physiological functions] ".Tanpakushitsu Kakusan Koso.47(3): 241–7.PMID11889801.
- de Groot RP, den Hertog J, Vandenheede JR, et al. (1993)."Multiple and cooperative phosphorylation events regulate the CREM activator function".EMBO J.12(10): 3903–11.doi:10.1002/j.1460-2075.1993.tb06068.x.PMC413673.PMID8404858.
- Tombes RM, Krystal GW (1997)."Identification of novel human tumor cell-specific CaMK-II variants".Biochim. Biophys. Acta.1355(3): 281–92.doi:10.1016/S0167-4889(96)00141-3.PMID9060999.
- Moyers JS, Bilan PJ, Zhu J, Kahn CR (1997)."Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II".J. Biol. Chem.272(18): 11832–9.doi:10.1074/jbc.272.18.11832.PMID9115241.
- Möhlig M, Wolter S, Mayer P, et al. (1997)."Insulinoma cells contain an isoform of Ca2+/calmodulin-dependent protein kinase II delta associated with insulin secretion vesicles ".Endocrinology.138(6): 2577–84.doi:10.1210/endo.138.6.5168.PMID9165051.
- Bauch A, Campbell KS, Reth M (1998)."Interaction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdelta ".Eur. J. Immunol.28(7): 2167–77.doi:10.1002/(SICI)1521-4141(199807)28:07<2167::AID-IMMU2167>3.0.CO;2-L.PMID9692886.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999)."Toward a complete human genome sequence".Genome Res.8(11): 1097–108.doi:10.1101/gr.8.11.1097.PMID9847074.
- Hoch B, Meyer R, Hetzer R, et al. (1999)."Identification and expression of delta-isoforms of the multifunctional Ca2+/calmodulin-dependent protein kinase in failing and nonfailing human myocardium ".Circ. Res.84(6): 713–21.doi:10.1161/01.res.84.6.713.PMID10189359.
- Tombes RM, Mikkelsen RB, Jarvis WD, Grant S (1999)."Downregulation of delta CaM kinase II in human tumor cells".Biochim. Biophys. Acta.1452(1): 1–11.doi:10.1016/S0167-4889(99)00113-5.PMID10525155.
- Rochlitz H, Voigt A, Lankat-Buttgereit B, et al. (2000)."Cloning and quantitative determination of the human Ca2+/calmodulin-dependent protein kinase II (CaMK II) isoforms in human beta cells ".Diabetologia.43(4): 465–73.doi:10.1007/s001250051330.PMID10819240.
- Inagaki N, Nishizawa M, Arimura N, et al. (2000)."Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons ".J. Biol. Chem.275(35): 27165–71.doi:10.1074/jbc.M003751200.PMID10852918.
- Nair JS, DaFonseca CJ, Tjernberg A, et al. (2002)."Requirement of Ca2+and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma ".Proc. Natl. Acad. Sci. U.S.A.99(9): 5971–6.Bibcode:2002PNAS...99.5971N.doi:10.1073/pnas.052159099.PMC122886.PMID11972023.
- Mishra-Gorur K, Singer HA, Castellot JJ (2002)."The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II ".J. Biol. Chem.277(37): 33537–40.doi:10.1074/jbc.C200342200.PMID12145273.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Gaertner TR, Kolodziej SJ, Wang D, et al. (2004)."Comparative analyses of the three-dimensional structures and enzymatic properties of alpha, beta, gamma and delta isoforms of Ca2+-calmodulin-dependent protein kinase II ".J. Biol. Chem.279(13): 12484–94.doi:10.1074/jbc.M313597200.PMID14722083.
- Ballif BA, Villén J, Beausoleil SA, et al. (2005)."Phosphoproteomic analysis of the developing mouse brain".Mol. Cell. Proteomics.3(11): 1093–101.doi:10.1074/mcp.M400085-MCP200.PMID15345747.
External links
[edit]- HumanCAMK2Dgenome location andCAMK2Dgene details page in theUCSC Genome Browser.