CARM1
| coactivator-associated arginine methyltransferase 1 | |||||||
|---|---|---|---|---|---|---|---|
 Crystal Structure of Coactivator Associated Arginine Methyltransferase 1[1] | |||||||
| Identifiers | |||||||
| Symbol | CARM1 | ||||||
| NCBI gene | 10498 | ||||||
| HGNC | 23393 | ||||||
| OMIM | 603934 | ||||||
| RefSeq | XM_032719 | ||||||
| UniProt | Q86X55 | ||||||
| Other data | |||||||
| EC number | 2.1.1.125 | ||||||
| Locus | Chr. 19p13.2 | ||||||
| |||||||
| coactivator associated arginine methyltransferase 1-like | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CARM1L | ||||||
| NCBI gene | 256280 | ||||||
| HGNC | 23392 | ||||||
| RefSeq | XM_171224 | ||||||
| UniProt | Q5SZY8 | ||||||
| Other data | |||||||
| Locus | Chr. 9p24.2 | ||||||
| |||||||
CARM1(coactivator-associated arginine methyltransferase 1), also known as PRMT4 (protein arginine N-methyltransferase 4), is anenzyme(EC2.1.1.125) encoded by theCARM1gene found in human beings, as well as many other mammals.[2]It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets.[3]Its main function includes catalyzing the transfer of a methyl group fromS-Adenosyl methionineto the side chain nitrogens ofarginineresidues within proteins to form methylated arginine derivatives andS-Adenosyl-L-homocysteine.[4]CARM1 is a secondarycoactivatorthrough its association with p160 family (SRC-1,GRIP1,AIB) of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.[5]
Clinical significance
[edit]CARM1 plays an important role in androgen receptors and may play a role in prostate cancer progression.[6][7]
CARM1 exerts both oncogenic and tumor-suppressive functions. In breast cancer, CARM1 methylateschromatin remodelingfactor BAF155 to enhance tumor progression and metastasis.[8]Inpancreatic cancer,CARM1 methylates and inhibitsMDH1by disrupting its dimerization, which represses mitochondria respiration and inhibits glutamine utilization. CARM1-mediated MDH1 methylation reduces cellularNADPHlevel and sensitizes cells tooxidative stress,thereby suppressing cell proliferation and colony formation.[9]
See also
[edit]External links
[edit]- coactivator-associated arginine methyltransferase 1at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- NURSAC30
References
[edit]- ^"RCSB Protein Data Bank - Structure Summary for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR".
- ^Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR (1999). "Regulation of transcription by a protein methyltransferase".Science.284(5423): 2174–7.doi:10.1126/science.284.5423.2174.PMID10381882.
- ^"RCSB Protein Data Bank - Sequence / Structure Details for 2Y1W - CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR".Archived fromthe originalon 2015-09-24.Retrieved2011-04-13.
- ^"CARM1 Gene - GeneCards | CARM1 Protein | CARM1 Antibody".
- ^Torres-Padilla ME, Parfitt DE, Kouzarides T, Zernicka-Goetz M (2007)."Histone arginine methylation regulates pluripotency in the early mouse embryo".Nature.445(7124): 214–8.Bibcode:2007Natur.445..214T.doi:10.1038/nature05458.PMC3353120.PMID17215844.
- ^Hong H, Kao C, Jeng MH, Eble JN, Koch MO, Gardner TA, Zhang S, Li L, Pan CX, Hu Z, MacLennan GT, Cheng L (2004). "Aberrant expression of CARM1, a transcriptional coactivator of androgen receptor, in the development of prostate carcinoma and androgen-independent status".Cancer.101(1): 83–9.doi:10.1002/cncr.20327.PMID15221992.S2CID274474.
- ^Majumder S, Liu Y, Ford OH, Mohler JL, Whang YE (2006). "Involvement of arginine methyltransferase CARM1 in androgen receptor function and prostate cancer cell viability".Prostate.66(12): 1292–301.doi:10.1002/pros.20438.PMID16705743.S2CID23950904.
- ^Wang L, Zhao Z, Meyer MB, Saha S, Yu M, Guo A, Wisinski KB, Huang W, Cai W, Pike JW, Yuan M, Ahlquist P, Xu W (Jul 2016)."CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis".Cancer Cell.30(1): 179–180.doi:10.1016/j.ccr.2013.12.007.PMC4004525.PMID24434208.
- ^Wang YP, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, Cheng JK, Lei QY (Nov 2016)."Arginine Methylation of MDH1 by CARM1 Inhibits Glutamine Metabolism and Suppresses Pancreatic Cancer".Molecular Cell.64(4): 673–87.doi:10.1016/j.molcel.2016.09.028.PMID27840030.
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