CCL19
Chemokine (C-C motif) ligand 19(CCL19) is aproteinthat in humans is encoded by theCCL19gene.[5][6]
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptorCCR7.[6]
Chemokine (C-C motif) ligand 19 (CCL19) is a smallcytokinebelonging to the CCchemokinefamily that is also known asEBI1 ligand chemokine(ELC) andmacrophage inflammatory protein-3-beta(MIP-3-beta). CCL19 is expressed abundantly inthymusandlymph nodes,with moderate levels intracheaandcolonand low levels in stomach,small intestine,lung,kidneyandspleen.[7]The gene for CCL19 is located on humanchromosome 9.[8]This chemokine elicits its effects on its target cells by binding to the chemokine receptorchemokine receptorCCR7.[7]It attracts certain cells of theimmune system,includingdendritic cellsand antigen-engagedB cells,[9][10]CCR7+central-memory T-Cells.[11]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000172724–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000118633–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Yoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (Jul 1997)."Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7".J Biol Chem.272(21): 13803–9.doi:10.1074/jbc.272.21.13803.PMID9153236.
- ^ab"Entrez Gene: CCL19 chemokine (C-C motif) ligand 19".
- ^abYoshida R, Imai T, Hieshima K, Kusuda J, Baba M, Kitaura M, Nishimura M, Kakizaki M, Nomiyama H, Yoshie O (1997)."Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7".J. Biol. Chem.272(21): 13803–9.doi:10.1074/jbc.272.21.13803.PMID9153236.
- ^Rossi DL, Vicari AP, Franz-Bacon K, McClanahan TK, Zlotnik A (1997)."Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta".J. Immunol.158(3): 1033–6.doi:10.4049/jimmunol.158.3.1033.PMID9013939.S2CID39291729.
- ^Robbiani DF, Finch RA, Jäger D, Muller WA, Sartorelli AC, Randolph GJ (2000)."The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes".Cell.103(5): 757–68.doi:10.1016/S0092-8674(00)00179-3.PMID11114332.S2CID15592251.
- ^Reif K, Ekland EH, Ohl L, Nakano H, Lipp M, Förster R, Cyster JG (2002). "Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position".Nature.416(6876): 94–9.Bibcode:2002Natur.416...94R.doi:10.1038/416094a.PMID11882900.S2CID4403093.
- ^Bromley SK, Thomas SY, Luster AD (2005). "Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics".Nat. Immunol.6(9): 895–901.doi:10.1038/ni1240.PMID16116469.S2CID443455.
Further reading
[edit]- Weber C, Koenen RR (2006). "Fine-tuning leukocyte responses: towards a chemokine 'interactome'".Trends Immunol.27(6): 268–73.doi:10.1016/j.it.2006.04.002.PMID16678487.
- Rossi DL, Vicari AP, Franz-Bacon K, et al. (1997)."Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta".J. Immunol.158(3): 1033–6.doi:10.4049/jimmunol.158.3.1033.PMID9013939.S2CID39291729.
- Nagira M, Imai T, Hieshima K, et al. (1997)."Molecular cloning of a novel human CC chemokine secondary lymphoid-tissue chemokine that is a potent chemoattractant for lymphocytes and mapped to chromosome 9p13".J. Biol. Chem.272(31): 19518–24.doi:10.1074/jbc.272.31.19518.PMID9235955.
- Kim CH, Pelus LM, White JR, et al. (1998)."CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells".J. Immunol.160(5): 2418–24.doi:10.4049/jimmunol.160.5.2418.PMID9498785.S2CID82739698.
- Yanagihara S, Komura E, Nagafune J, et al. (1998)."EBI1/CCR7 is a new member of dendritic cell chemokine receptor that is up-regulated upon maturation".J. Immunol.161(6): 3096–102.doi:10.4049/jimmunol.161.6.3096.PMID9743376.S2CID26084149.
- Gosling J, Dairaghi DJ, Wang Y, et al. (2000)."Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK".J. Immunol.164(6): 2851–6.doi:10.4049/jimmunol.164.6.2851.PMID10706668.
- Annunziato F, Romagnani P, Cosmi L, et al. (2000)."Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection".J. Immunol.165(1): 238–46.doi:10.4049/jimmunol.165.1.238.PMID10861057.
- Ueno T, Hara K, Willis MS, et al. (2002)."Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus".Immunity.16(2): 205–18.doi:10.1016/S1074-7613(02)00267-4.PMID11869682.
- Phillips R, Ager A (2002)."Activation of pertussis toxin-sensitive CXCL12 (SDF-1) receptors mediates transendothelial migration of T lymphocytes across lymph node high endothelial cells".Eur. J. Immunol.32(3): 837–47.doi:10.1002/1521-4141(200203)32:3<837::AID-IMMU837>3.0.CO;2-Q.PMID11870628.S2CID41323072.
- Till KJ, Lin K, Zuzel M, Cawley JC (2002)."The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes".Blood.99(8): 2977–84.doi:10.1182/blood.V99.8.2977.PMID11929789.
- Townson JR, Nibbs RJ (2002). "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR".Eur. J. Immunol.32(5): 1230–41.doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L.PMID11981810.S2CID21911348.
- Page G, Lebecque S, Miossec P (2002)."Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synovium".J. Immunol.168(10): 5333–41.doi:10.4049/jimmunol.168.10.5333.PMID11994492.
- Katou F, Ohtani H, Nakayama T, et al. (2003). "Differential expression of CCL19 by DC-Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skin".J. Pathol.199(1): 98–106.doi:10.1002/path.1255.PMID12474232.S2CID25424987.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Scandella E, Men Y, Legler DF, et al. (2004)."CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2".Blood.103(5): 1595–601.doi:10.1182/blood-2003-05-1643.PMID14592837.
- Corcione A, Arduino N, Ferretti E, et al. (2004). "CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells".Clin. Cancer Res.10(3): 964–71.doi:10.1158/1078-0432.CCR-1182-3.PMID14871974.S2CID9041635.
- Daikoku N, Kitaya K, Nakayama T, et al. (2004)."Expression of macrophage inflammatory protein-3beta in human endometrium throughout the menstrual cycle".Fertil. Steril.81(Suppl 1): 876–81.doi:10.1016/j.fertnstert.2003.09.036.PMID15019823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Paoletti S, Petkovic V, Sebastiani S, et al. (2005)."A rich chemokine environment strongly enhances leukocyte migration and activities".Blood.105(9): 3405–12.doi:10.1182/blood-2004-04-1648.PMID15546958.
External links
[edit]- HumanCCL19genome location andCCL19gene details page in theUCSC Genome Browser.