CCR1

CCR1
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 1Y5D
Identifiers
Aliases	CCR1,CD191, CKR-1, CKR1, CMKBR1, HM145, MIP1aR, SCYAR1, C-C motif chemokine receptor 1
External IDs	OMIM:601159;MGI:104618;HomoloGene:20344;GeneCards:CCR1;OMA:CCR1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 46,201,711bp End 46,208,313bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F4|9 75.05 cM Start 123,762,161bp End 123,768,729bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in monocyte blood granulocyte periodontal fiber buccal mucosa cell appendix spleen decidua bone marrow trabecular bone Top expressed in granulocyte stroma of bone marrow tibiofemoral joint blood ankle body of femur spleen ankle joint lumbar subsegment of spinal cord duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function C-C chemokine binding G protein-coupled receptor activity chemokine (C-C motif) ligand 5 binding signal transducer activity chemokine (C-C motif) ligand 7 binding protein binding chemokine receptor activity C-C chemokine receptor activity phosphatidylinositol phospholipase C activity chemokine binding Cellular component integral component of membrane membrane plasma membrane integral component of plasma membrane external side of plasma membrane cytoplasm Biological process negative regulation of bone mineralization positive regulation of cell migration positive regulation of cytosolic calcium ion concentration chemokine-mediated signaling pathway cell-cell signaling G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger positive regulation of monocyte chemotaxis cellular calcium ion homeostasis positive regulation of osteoclast differentiation dendritic cell chemotaxis negative regulation of gene expression chemotaxis cell surface receptor signaling pathway cell adhesion response to wounding immune response positive regulation of ERK1 and ERK2 cascade inflammatory response calcium ion transport signal transduction exocytosis positive regulation of calcium ion transport G protein-coupled receptor signaling pathway cytokine-mediated signaling pathway calcium-mediated signaling cell chemotaxis Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 1230 12768 Ensembl ENSG00000163823 ENSMUSG00000025804 UniProt P32246 P51675 RefSeq (mRNA) NM_001295 NM_009912 RefSeq (protein) NP_001286 NP_034042 Location (UCSC) Chr 3: 46.2 – 46.21 Mb Chr 9: 123.76 – 123.77 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

C-C chemokine receptor type 1is aproteinthat in humans is encoded by theCCR1gene.

CCR1 has also recently been designatedCD191(cluster of differentiation191).

Function

This gene encodes a member of thebeta chemokine receptorfamily, which belongs toG protein-coupled receptors.The ligands of this receptor includeCCL3(or MIP-1 alpha),CCL5(or RANTES),CCL7(or MCP-3), andCCL23(or MPIF-1).Chemokinesand their receptors, which mediatesignal transduction,are critical for the recruitment of effectorimmune cellsto the site ofinflammation.Knockoutstudies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, includingCCR2,CCRL2,CCR3,CCR5andCXCR1,are found to form a gene cluster on chromosome 3p.

Interactions

CCR1 has been shown tointeractwithCCL5.

Further reading

• Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor".Annual Review of Immunology.12(1): 775–808.doi:10.1146/annurev.iy.12.040194.004015.PMID8011297.
• Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (January 2004). "HIV-1 infection and chemokine receptor modulation".Current HIV Research.2(1): 39–50.doi:10.2174/1570162043484997.PMID15053339.
• Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors".International Immunology.5(10): 1239–49.doi:10.1093/intimm/5.10.1239.PMID7505609.
• Ben-Baruch A, Xu L, Young PR, Bengali K, Oppenheim JJ, Wang JM (September 1995)."Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3".The Journal of Biological Chemistry.270(38): 22123–8.doi:10.1074/jbc.270.38.22123.PMID7545673.
• Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (December 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors".Journal of Immunology.155(11): 5299–305.doi:10.4049/jimmunol.155.11.5299.PMID7594543.S2CID12074627.
• Gao JL, Kuhns DB, Tiffany HL, McDermott D, Li X, Francke U, Murphy PM (May 1993)."Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor".The Journal of Experimental Medicine.177(5): 1421–7.doi:10.1084/jem.177.5.1421.PMC2191019.PMID7683036.
• Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM (December 1995)."Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B".The Journal of Biological Chemistry.270(50): 29671–5.doi:10.1074/jbc.270.50.29671.PMID8530354.
• Kuang Y, Wu Y, Jiang H, Wu D (February 1996)."Selective G protein coupling by C-C chemokine receptors".The Journal of Biological Chemistry.271(8): 3975–8.doi:10.1074/jbc.271.8.3975.PMID8626727.
• Boring L, Gosling J, Monteclaro FS, Lusis AJ, Tsou CL, Charo IF (March 1996)."Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9".The Journal of Biological Chemistry.271(13): 7551–8.doi:10.1074/jbc.271.13.7551.PMID8631787.
• Gong X, Gong W, Kuhns DB, Ben-Baruch A, Howard OM, Wang JM (May 1997)."Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors".The Journal of Biological Chemistry.272(18): 11682–5.doi:10.1074/jbc.272.18.11682.PMID9115216.
• Daugherty BL, Springer MS (April 1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21".Genomics.41(2): 294–5.doi:10.1006/geno.1997.4626.PMID9143512.
• Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA (August 1997). "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5".Biochemistry.36(32): 9642–8.doi:10.1021/bi970593z.PMID9289016.
• Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN (September 1997)."Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines".European Journal of Biochemistry.248(2): 507–15.doi:10.1111/j.1432-1033.1997.00507.x.PMID9346309.
• Youn BS, Zhang SM, Broxmeyer HE, Cooper S, Antol K, Fraser M, Kwon BS (May 1998)."Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1".Blood.91(9): 3118–26.doi:10.1182/blood.V91.9.3118.PMID9558365.
• Nardelli B, Tiffany HL, Bong GW, Yourey PA, Morahan DK, Li Y, Murphy PM, Alderson RF (January 1999)."Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1".Journal of Immunology.162(1): 435–44.doi:10.4049/jimmunol.162.1.435.PMID9886417.
• Shaw KT, Greig NH (January 1999)."Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection".NeuroReport.10(1): 53–6.doi:10.1097/00001756-199901180-00010.PMID10094132.
• Zhang S, Youn BS, Gao JL, Murphy PM, Kwon BS (April 1999)."Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1".Journal of Immunology.162(8): 4938–42.doi:10.4049/jimmunol.162.8.4938.PMID10202040.
• Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G (December 1999). "Use of chemokine receptors by poxviruses".Science.286(5446): 1968–71.doi:10.1126/science.286.5446.1968.PMID10583963.

External links

• HumanCCR1genome location andCCR1gene details page in theUCSC Genome Browser.
• "Chemokine Receptors: CCR1".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2008-06-07.Retrieved2008-11-25.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.