CCR1
C-C chemokine receptor type 1is aproteinthat in humans is encoded by theCCR1gene.[5]
CCR1 has also recently been designatedCD191(cluster of differentiation191).
Function
[edit]This gene encodes a member of thebeta chemokine receptorfamily, which belongs toG protein-coupled receptors.The ligands of this receptor includeCCL3(or MIP-1 alpha),CCL5(or RANTES),CCL7(or MCP-3), andCCL23(or MPIF-1).Chemokinesand their receptors, which mediatesignal transduction,are critical for the recruitment of effectorimmune cellsto the site ofinflammation.Knockoutstudies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, includingCCR2,CCRL2,CCR3,CCR5andCXCR1,are found to form a gene cluster on chromosome 3p.[6]
Interactions
[edit]CCR1 has been shown tointeractwithCCL5.[7][8]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000163823–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000025804–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Neote K, DiGregorio D, Mak JY, Horuk R, Schall TJ (February 1993). "Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor".Cell.72(3): 415–25.doi:10.1016/0092-8674(93)90118-A.PMID7679328.S2CID38479816.
- ^"Entrez Gene: CCR1 chemokine (C-C motif) receptor 1".
- ^Struyf S, Menten P, Lenaerts JP, Put W, D'Haese A, De Clercq E, Schols D, Proost P, Van Damme J (July 2001)."Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils".European Journal of Immunology.31(7): 2170–8.doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D.PMID11449371.
- ^Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, Trkola A, Marchant D, Clapham PR, Wells TN (April 2001)."The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity".The Journal of Biological Chemistry.276(14): 10620–6.doi:10.1074/jbc.M010867200.PMID11116158.
Further reading
[edit]- Gerard C, Gerard NP (1994). "C5A anaphylatoxin and its seven transmembrane-segment receptor".Annual Review of Immunology.12(1): 775–808.doi:10.1146/annurev.iy.12.040194.004015.PMID8011297.
- Ruibal-Ares BH, Belmonte L, Baré PC, Parodi CM, Massud I, de Bracco MM (January 2004). "HIV-1 infection and chemokine receptor modulation".Current HIV Research.2(1): 39–50.doi:10.2174/1570162043484997.PMID15053339.
- Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors".International Immunology.5(10): 1239–49.doi:10.1093/intimm/5.10.1239.PMID7505609.
- Ben-Baruch A, Xu L, Young PR, Bengali K, Oppenheim JJ, Wang JM (September 1995)."Monocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3".The Journal of Biological Chemistry.270(38): 22123–8.doi:10.1074/jbc.270.38.22123.PMID7545673.
- Post TW, Bozic CR, Rothenberg ME, Luster AD, Gerard N, Gerard C (December 1995). "Molecular characterization of two murine eosinophil beta chemokine receptors".Journal of Immunology.155(11): 5299–305.doi:10.4049/jimmunol.155.11.5299.PMID7594543.S2CID12074627.
- Gao JL, Kuhns DB, Tiffany HL, McDermott D, Li X, Francke U, Murphy PM (May 1993)."Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor".The Journal of Experimental Medicine.177(5): 1421–7.doi:10.1084/jem.177.5.1421.PMC2191019.PMID7683036.
- Combadiere C, Ahuja SK, Van Damme J, Tiffany HL, Gao JL, Murphy PM (December 1995)."Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B".The Journal of Biological Chemistry.270(50): 29671–5.doi:10.1074/jbc.270.50.29671.PMID8530354.
- Kuang Y, Wu Y, Jiang H, Wu D (February 1996)."Selective G protein coupling by C-C chemokine receptors".The Journal of Biological Chemistry.271(8): 3975–8.doi:10.1074/jbc.271.8.3975.PMID8626727.
- Boring L, Gosling J, Monteclaro FS, Lusis AJ, Tsou CL, Charo IF (March 1996)."Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1alpha receptors: evidence for two closely linked C-C chemokine receptors on chromosome 9".The Journal of Biological Chemistry.271(13): 7551–8.doi:10.1074/jbc.271.13.7551.PMID8631787.
- Gong X, Gong W, Kuhns DB, Ben-Baruch A, Howard OM, Wang JM (May 1997)."Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptors".The Journal of Biological Chemistry.272(18): 11682–5.doi:10.1074/jbc.272.18.11682.PMID9115216.
- Daugherty BL, Springer MS (April 1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21".Genomics.41(2): 294–5.doi:10.1006/geno.1997.4626.PMID9143512.
- Pakianathan DR, Kuta EG, Artis DR, Skelton NJ, Hébert CA (August 1997). "Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5".Biochemistry.36(32): 9642–8.doi:10.1021/bi970593z.PMID9289016.
- Coulin F, Power CA, Alouani S, Peitsch MC, Schroeder JM, Moshizuki M, Clark-Lewis I, Wells TN (September 1997)."Characterisation of macrophage inflammatory protein-5/human CC cytokine-2, a member of the macrophage-inflammatory-protein family of chemokines".European Journal of Biochemistry.248(2): 507–15.doi:10.1111/j.1432-1033.1997.00507.x.PMID9346309.
- Youn BS, Zhang SM, Broxmeyer HE, Cooper S, Antol K, Fraser M, Kwon BS (May 1998)."Characterization of CKbeta8 and CKbeta8-1: two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1".Blood.91(9): 3118–26.doi:10.1182/blood.V91.9.3118.PMID9558365.
- Nardelli B, Tiffany HL, Bong GW, Yourey PA, Morahan DK, Li Y, Murphy PM, Alderson RF (January 1999)."Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1".Journal of Immunology.162(1): 435–44.doi:10.4049/jimmunol.162.1.435.PMID9886417.
- Shaw KT, Greig NH (January 1999)."Chemokine receptor mRNA expression at the in vitro blood-brain barrier during HIV infection".NeuroReport.10(1): 53–6.doi:10.1097/00001756-199901180-00010.PMID10094132.
- Zhang S, Youn BS, Gao JL, Murphy PM, Kwon BS (April 1999)."Differential effects of leukotactin-1 and macrophage inflammatory protein-1 alpha on neutrophils mediated by CCR1".Journal of Immunology.162(8): 4938–42.doi:10.4049/jimmunol.162.8.4938.PMID10202040.
- Lalani AS, Masters J, Zeng W, Barrett J, Pannu R, Everett H, Arendt CW, McFadden G (December 1999). "Use of chemokine receptors by poxviruses".Science.286(5446): 1968–71.doi:10.1126/science.286.5446.1968.PMID10583963.
External links
[edit]- HumanCCR1genome location andCCR1gene details page in theUCSC Genome Browser.
- "Chemokine Receptors: CCR1".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2008-06-07.Retrieved2008-11-25.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.