Integrin alpha 5
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Integrin alpha-5is aproteinthat in humans is encoded by theITGA5gene.[5]
The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.[6]
Interactions
[edit]ITGA5 has been shown tointeractwithGIPC1.[7]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000161638–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000000555–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Sosnoski DM, Emanuel BS, Hawkins AL, van Tuinen P, Ledbetter DH, Nussbaum RL, Kaos FT, Schwartz E, Phillips D, Bennett JS, et al. (Aug 1988)."Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and IIIa".J Clin Invest.81(6): 1993–8.doi:10.1172/JCI113548.PMC442653.PMID2454952.
- ^"Entrez Gene: ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)".
- ^Tani TT, Mercurio A M (Sep 2001)."PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B".J. Biol. Chem.276(39). United States: 36535–42.doi:10.1074/jbc.M105785200.ISSN0021-9258.PMID11479315.
Further reading
[edit]- Ruoslahti E (1996). "Integrin signaling and matrix assembly".Tumour Biol.17(2): 117–24.doi:10.1159/000217975.PMID8658014.
- Coulombel L, Auffray I, Gaugler MH, Rosemblatt M (1997). "Expression and function of integrins on hematopoietic progenitor cells".Acta Haematol.97(1–2): 13–21.doi:10.1159/000203655.PMID8980606.
- Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors".Trends Cell Biol.8(10): 390–6.doi:10.1016/S0962-8924(98)01344-0.PMID9789327.
- Evans JP (2001). "Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization".BioEssays.23(7): 628–39.doi:10.1002/bies.1088.PMID11462216.S2CID23712246.
External links
[edit]- CD49e+Antigenat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- ITGA5Info with links in theCell Migration GatewayArchived2014-12-11 at theWayback Machine
- Overview of all the structural information available in thePDBforUniProt:P08648(Human Integrin alpha-5) at thePDBe-KB.