Cadherin-12is aproteinthat in humans is encoded by theCDH12gene.[5][6]
This gene encodes a type II classicalcadherinfrom the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and itstemporal patternof expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[6]
Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin".Cell Adhes. Commun.2(1): 15–26.doi:10.3109/15419069409014199.PMID7982033.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity".Genomics.49(3): 467–71.doi:10.1006/geno.1998.5281.PMID9615235.
Chalmers IJ, Höfler H, Atkinson MJ (1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma".Genomics.57(1): 160–3.doi:10.1006/geno.1998.5717.PMID10191097.
