CDH16

CDH16
Identifiers
Aliases	CDH16,cadherin 16
External IDs	OMIM:603118;MGI:106671;HomoloGene:2997;GeneCards:CDH16;OMA:CDH16 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) Band 16q22.1 Start 66,908,122bp End 66,918,917bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 D3|8 53.04 cM Start 105,328,543bp End 105,351,028bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in renal medulla kidney tubule left lobe of thyroid gland right lobe of thyroid gland glomerulus metanephric glomerulus human kidney muscle of thigh caput epididymis gonad Top expressed in human kidney right kidney medullary collecting duct proximal tubule efferent ductule vas deferens renal corpuscle left lung lobe renal pelvis trachea More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding metal ion binding Cellular component integral component of membrane plasma membrane extracellular exosome membrane integral component of plasma membrane basolateral plasma membrane Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules cell adhesion homophilic cell adhesion via plasma membrane adhesion molecules cell-cell signaling nervous system development Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 1014 12556 Ensembl ENSG00000166589 ENSMUSG00000031881 UniProt O75309 O88338 RefSeq (mRNA) NM_001204744 NM_001204745 NM_001204746 NM_004062 NM_001252627 NM_001252628 NM_007663 RefSeq (protein) NP_001191673 NP_001191674 NP_001191675 NP_004053 NP_001239556 NP_001239557 NP_031689 Location (UCSC) Chr 16: 66.91 – 66.92 Mb Chr 8: 105.33 – 105.35 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-16is a protein that in humans is encoded by theCDH16gene.

This gene is a member of thecadherinsuperfamily, genes encoding calcium-dependent, membrane-associatedglycoproteins.Mapped to a previously identified cluster of cadherin genes onchromosome 16q22.1, the gene localizes with superfamily membersCDH1,CDH3,CDH5,CDH8andCDH11.The protein consists of anextracellular domaincontaining 6 cadherin domains, atransmembrane regionand a truncatedcytoplasmicdomain but lacks theprosequenceandtripeptideHAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in the kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in themorphogenicdirection of tissue development.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Thomson RB, Aronson PS (1999). "Immunolocalization of Ksp-cadherin in the adult and developing rabbit kidney".Am. J. Physiol.277(1 Pt 2): F146–56.doi:10.1152/ajprenal.1999.277.1.F146.PMID10409308.
• Baudry D, Jeanpierre C (2000). "Assignment of E-cadherin (CDH1) and KSP-cadherin (CDH16) to chromosome 16q22.1 by radiation hybrid mapping".Cytogenet. Cell Genet.88(3–4): 253–4.doi:10.1159/000015531.PMID10828602.S2CID83989085.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Thomson RB, Mentone S, Kim R, et al. (2003). "Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD".Am. J. Physiol. Renal Physiol.285(5): F870–80.doi:10.1152/ajprenal.00153.2003.PMID12851251.
• Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Wendeler MW, Praus M, Jung R, et al. (2004). "Ksp-cadherin is a functional cell-cell adhesion molecule related to LI-cadherin".Exp. Cell Res.294(2): 345–55.doi:10.1016/j.yexcr.2003.11.022.PMID15023525.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Hishikawa K, Marumo T, Miura S, et al. (2005). "Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16".Biochem. Biophys. Res. Commun.328(1): 288–91.doi:10.1016/j.bbrc.2004.12.167.PMID15670782.
• Thedieck C, Kuczyk M, Klingel K, et al. (2005)."Expression of Ksp-cadherin during kidney development and in renal cell carcinoma".Br. J. Cancer.92(11): 2010–7.doi:10.1038/sj.bjc.6602597.PMC2361784.PMID15886705.
• Kuehn A, Paner GP, Skinnider BF, et al. (2007). "Expression analysis of kidney-specific cadherin in a wide spectrum of traditional and newly recognized renal epithelial neoplasms: diagnostic and histogenetic implications".Am. J. Surg. Pathol.31(10): 1528–33.doi:10.1097/PAS.0b013e318058818c.PMID17895753.S2CID46401984.

External links

• CDH16human gene location in theUCSC Genome Browser.
• CDH16human gene details in theUCSC Genome Browser.