CDH4
Cadherin-4is aproteinthat in humans is encoded by theCDH4gene.[5][6][7]
This gene is a classicalcadherinfrom the cadherin superfamily. The encoded protein is a calcium-dependentcell-cell adhesionglycoproteincomposed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[7]
Interactions
[edit]Cadherin-4 has been shown tointeractwith:
References
[edit]- ^abcENSG00000179242 GRCh38: Ensembl release 89: ENSG00000280641, ENSG00000179242–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000000305–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma".Genomics.57(1): 160–3.doi:10.1006/geno.1998.5717.PMID10191097.
- ^Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3".Cytogenet Cell Genet.86(1): 26–7.doi:10.1159/000015423.PMID10516427.S2CID27578498.
- ^ab"Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)".
- ^Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998)."Dynamic interaction of PTPmu with multiple cadherins in vivo".J Cell Biol.141(1): 287–96.doi:10.1083/jcb.141.1.287.PMC2132733.PMID9531566.
Further reading
[edit]- Tagliarini F (1977). "[Relations between social defense and criminological trends from the 1930s until today]".Quaderni di Criminologia Clinica.18(3): 289–352.PMID798233.
- Suzuki S, Sano K, Tanihara H (1991)."Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue".Cell Regul.2(4): 261–70.doi:10.1091/mbc.2.4.261.PMC361775.PMID2059658.
- Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin".Cell Adhes. Commun.2(1): 15–26.doi:10.3109/15419069409014199.PMID7982033.
- Shan WS, Tanaka H, Phillips GR, et al. (2000)."Functional cis-heterodimers of N- and R-cadherins".J. Cell Biol.148(3): 579–90.doi:10.1083/jcb.148.3.579.PMC2174798.PMID10662782.
- Lecanda F, Cheng SL, Shin CS, et al. (2000). "Differential regulation of cadherins by dexamethasone in human osteoblastic cells".J. Cell. Biochem.77(3): 499–506.doi:10.1002/(SICI)1097-4644(20000601)77:3<499::AID-JCB14>3.0.CO;2-0.PMID10760957.S2CID13331343.
- Kitagawa M, Natori M, Murase S, et al. (2000). "Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function".Biochem. Biophys. Res. Commun.271(2): 358–63.doi:10.1006/bbrc.2000.2636.PMID10799302.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002)."The DNA sequence and comparative analysis of human chromosome 20".Nature.414(6866): 865–71.Bibcode:2001Natur.414..865D.doi:10.1038/414865a.PMID11780052.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Johnson E, Theisen CS, Johnson KR, Wheelock MJ (2004)."R-cadherin influences cell motility via Rho family GTPases".J. Biol. Chem.279(30): 31041–9.doi:10.1074/jbc.M400024200.PMID15143071.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Miotto E, Sabbioni S, Veronese A, et al. (2005)."Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer".Cancer Res.64(22): 8156–9.doi:10.1158/0008-5472.CAN-04-3000.PMID15548679.
- Maeda M, Johnson E, Mandal SH, et al. (2006)."Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn)".Oncogene.25(33): 4595–604.doi:10.1038/sj.onc.1209396.PMID16786001.
External links
[edit]- CDH4human gene location in theUCSC Genome Browser.
- CDH4human gene details in theUCSC Genome Browser.