CELSR3

CELSR3
Identifiers
Aliases	CELSR3,CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3
External IDs	OMIM:604264;MGI:1858236;HomoloGene:1077;GeneCards:CELSR3;OMA:CELSR3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 48,636,463bp End 48,662,886bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 108,703,519bp End 108,730,168bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right hemisphere of cerebellum ganglionic eminence pituitary gland paraflocculus of cerebellum Brodmann area 10 cerebellar vermis anterior pituitary right frontal lobe postcentral gyrus Region I of hippocampus proper Top expressed in cerebellar cortex hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity signal transducer activity protein binding transmembrane signaling receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process regulation of protein phosphorylation dopaminergic neuron axon guidance G protein-coupled receptor signaling pathway serotonergic neuron axon guidance neuron migration regulation of protein localization multicellular organism development Wnt signaling pathway, planar cell polarity pathway cell surface receptor signaling pathway cell adhesion axonal fasciculation signal transduction homophilic cell adhesion via plasma membrane adhesion molecules planar cell polarity pathway involved in axon guidance cilium assembly cell-cell adhesion Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 1951 107934 Ensembl ENSG00000008300 ENSMUSG00000023473 UniProt Q9NYQ7 Q91ZI0 RefSeq (mRNA) NM_001407 NM_080437 NM_001359572 NM_001359573 RefSeq (protein) NP_001398 NP_536685 NP_001346501 NP_001346502 Location (UCSC) Chr 3: 48.64 – 48.66 Mb Chr 9: 108.7 – 108.73 Mb PubMedsearch
Wikidata
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Cadherin EGF LAG seven-pass G-type receptor 3is aproteinthat in humans is encoded by theCELSR3gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

See also

• Flamingo (protein)

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID8889548.
• Wu Q, Maniatis T (1999)."A striking organization of a large family of human neural cadherin-like cell adhesion genes".Cell.97(6): 779–90.doi:10.1016/S0092-8674(00)80789-8.PMID10380929.S2CID6014717.
• Wu Q, Maniatis T (2000)."Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes".Proc. Natl. Acad. Sci. U.S.A.97(7): 3124–9.doi:10.1073/pnas.060027397.PMC16203.PMID10716726.
• Formstone CJ, Barclay J, Rees M, Little PF (2000). "Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9".Mamm. Genome.11(5): 392–4.doi:10.1007/s003350010073.PMID10790539.S2CID21333332.
• Nakayama M, Kikuno R, Ohara O (2003)."Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs".Genome Res.12(11): 1773–84.doi:10.1101/gr.406902.PMC187542.PMID12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84(1): 23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.

External links

• HumanCELSR3genome location andCELSR3gene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.