CFU-Meg
| CFU-Meg | |
|---|---|
| Details | |
| Gives rise to | Megakaryocytesand those toplatelets |
| Location | Bone marrow |
| Function | Colony forming unit |
| Identifiers | |
| TH | H2.00.04.3.02013 |
| Anatomical terms of microanatomy | |
CFU-Megis acolony forming unit. Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production ofmegakaryocytes.[1][2][3]
Some sources prefer the term "CFU-Mega".[4]
See also
[edit]References
[edit]- ^Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S (1988). "Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes".Acta Haematol.79(1): 1–6.doi:10.1159/000205681.PMID3124455.
- ^Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S (January 1987). "Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg".Am. J. Hematol.24(1): 23–30.doi:10.1002/ajh.2830240104.PMID3799592.S2CID20893511.
- ^Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (December 1991)."Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells".J. Leukoc. Biol.50(6): 580–6.doi:10.1002/jlb.50.6.580.PMID1940611.S2CID9700067.[permanent dead link]
- ^Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005).Robbins and Cotran pathologic basis of disease.St. Louis, Mo: Elsevier Saunders. p. 621.ISBN0-7216-0187-1.
External links
[edit]- Megakaryocyte+Progenitor+Cellsat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
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