CISH (protein)
Cytokine-inducible SH2-containing proteinis aproteinthat in humans is encoded by theCISHgene.[5][6][7]CISHorthologs[8]have been identified in mostmammalswith sequenced genomes. CISH controls T cell receptor (TCR) signaling, and variations ofCISHwith certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.[9]
Function[edit]
The protein encoded by this gene contains aSH2 domainand aSOCS box domain.The protein thus belongs to thecytokine-induced STAT inhibitor(CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family.CIS familymembers are known to be cytokine-inducible negative regulators of cytokine signaling.
The expression of this gene can be induced by IL-2, IL-3, GM-CSF and EPO inhematopoieticcells.Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of theerythropoietin receptor.[7]
CISH is induced byT cell receptor(TCR) ligation and negatively regulates it by targeting the critical signaling intermediatePLC-gamma-1for degradation.[10]The deletion of Cish in effector T cells has been shown to augment TCR signaling and subsequent effector cytokine release, proliferation and survival. The adoptive transfer of tumor-specific effector T cells knocked out or knocked down for CISH resulted in a significant increase in functional avidity and long-term tumor immunity. There are no changes in activity or phosphorylation of Cish's purported target,STAT5in either the presence or absence of Cish.
In human tumor-infiltrating lymphocytes (TIL), CISH expression has been reported to be inversely expressed with known T cell activation/exhaustion markers and regulates their expression and neoantigen reactivity. Combination therapy with checkpoint blockade synergistically results in profound tumor regressing in a pre-clinical tumor model[11]
Interactions[edit]
CISH has been shown tointeractwithIL2RB[12]andGrowth hormone receptor.[13]andPLCG1.[10]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000114737–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000032578–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Uchida K, Yoshimura A, Inazawa J, Yanagisawa K, Osada H, Masuda A, Saito T, Takahashi T, Miyajima A, Takahashi T (Mar 1998). "Molecular cloning of CISH, chromosome assignment to 3p21.3, and analysis of expression in fetal and adult tissues".Cytogenetics and Cell Genetics.78(3–4): 209–12.doi:10.1159/000134658.PMID9465889.
- ^Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (Jun 1995)."A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors".The EMBO Journal.14(12): 2816–26.doi:10.1002/j.1460-2075.1995.tb07281.x.PMC398400.PMID7796808.
- ^ab"Entrez Gene: CISH cytokine inducible SH2-containing protein".
- ^"OrthoMaM phylogenetic marker: CISH coding sequence".Archived fromthe originalon 2016-03-04.Retrieved2010-02-17.
- ^Khor CC, Vannberg FO, Chapman SJ, Guo H, Wong SH, Walley AJ, Vukcevic D, Rautanen A, Mills TC, Chang KC, Kam KM, Crampin AC, Ngwira B, Leung CC, Tam CM, Chan CY, Sung JJ, Yew WW, Toh KY, Tay SK, Kwiatkowski D, Lienhardt C, Hien TT, Day NP, Peshu N, Marsh K, Maitland K, Scott JA, Williams TN, Berkley JA, Floyd S, Tang NL, Fine PE, Goh DL, Hill AV (Jun 2010)."CISH and susceptibility to infectious diseases".The New England Journal of Medicine.362(22): 2092–101.doi:10.1056/NEJMoa0905606.PMC3646238.PMID20484391.[Free Text]
- ^abPalmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP (Nov 2015)."Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance".The Journal of Experimental Medicine.212(12): 2095–113.doi:10.1084/jem.20150304.PMC4647263.PMID26527801.
- ^Palmer D, et al. (2020)."Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade".doi:10.21203/rs.3.rs-80800/v1.S2CID234737847.
{{cite journal}}:Cite journal requires|journal=(help) - ^Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu MH, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ (Oct 1999)."CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling".The Journal of Biological Chemistry.274(42): 30266–72.doi:10.1074/jbc.274.42.30266.PMID10514520.
- ^Ram PA, Waxman DJ (Dec 1999)."SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms".The Journal of Biological Chemistry.274(50): 35553–61.doi:10.1074/jbc.274.50.35553.PMID10585430.
Further reading[edit]
- Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation".Trends in Biochemical Sciences.27(5): 235–41.doi:10.1016/S0968-0004(02)02085-6.PMID12076535.
- Verdier F, Chrétien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C, Mayeux P (Oct 1998)."Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein".The Journal of Biological Chemistry.273(43): 28185–90.doi:10.1074/jbc.273.43.28185.PMID9774439.
- Okabe S, Tauchi T, Morita H, Ohashi H, Yoshimura A, Ohyashiki K (Oct 1999)."Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway".Experimental Hematology.27(10): 1542–7.doi:10.1016/S0301-472X(99)00094-6.PMID10517496.
- Jiang C, Yu L, Zhao Y, Zhang M, Liu Q, Mao N, Geng Z, Zhao S (2000). "Cloning and characterization of CIS 1b (cytokine inducible SH2-containing protein 1b), an alternative splicing form of CIS 1 gene".DNA Sequence.11(1–2): 149–54.doi:10.3109/10425170009033983.PMID10902923.S2CID7986394.
- Dogusan Z, Hooghe-Peters EL, Berus D, Velkeniers B, Hooghe R (Sep 2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines".Journal of Neuroimmunology.109(1): 34–9.doi:10.1016/S0165-5728(00)00300-3.PMID10969179.S2CID23752435.
- Yousefi S, Cooper PR, Mueck B, Potter SL, Jarai G (Oct 2000). "cDNA representational difference analysis of human neutrophils stimulated by GM-CSF".Biochemical and Biophysical Research Communications.277(2): 401–9.doi:10.1006/bbrc.2000.3678.PMID11032736.
- Dif F, Saunier E, Demeneix B, Kelly PA, Edery M (Dec 2001)."Cytokine-inducible SH2-containing protein suppresses PRL signaling by binding the PRL receptor".Endocrinology.142(12): 5286–93.doi:10.1210/endo.142.12.8549.PMID11713228.
- Federici M, Giustizieri ML, Scarponi C, Girolomoni G, Albanesi C (Jul 2002)."Impaired IFN-gamma-dependent inflammatory responses in human keratinocytes overexpressing the suppressor of cytokine signaling 1".Journal of Immunology.169(1): 434–42.doi:10.4049/jimmunol.169.1.434.PMID12077274.
- Du L, Frick GP, Tai LR, Yoshimura A, Goodman HM (Mar 2003)."Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes".Endocrinology.144(3): 868–76.doi:10.1210/en.2002-220830.PMID12586763.
- Chen S, Anderson PO, Li L, Sjögren HO, Wang P, Li SL (Mar 2003)."Functional association of cytokine-induced SH2 protein and protein kinase C in activated T cells".International Immunology.15(3): 403–9.doi:10.1093/intimm/dxg039.PMID12618484.
- Yamasaki K, Hanakawa Y, Tokumaru S, Shirakata Y, Sayama K, Hanada T, Yoshimura A, Hashimoto K (Apr 2003)."Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes".The Journal of Investigative Dermatology.120(4): 571–80.doi:10.1046/j.1523-1747.2003.12100.x.hdl:11094/44640.PMID12648219.
- Cheng J, Zhang D, Zhou C, Marasco WA (Jan 2004). "Down-regulation of SHP1 and up-regulation of negative regulators of JAK/STAT signaling in HTLV-1 transformed cell lines and freshly transformed human peripheral blood CD4+ T-cells".Leukemia Research.28(1): 71–82.doi:10.1016/S0145-2126(03)00158-9.PMID14630083.
- Bayle J, Letard S, Frank R, Dubreuil P, De Sepulveda P (Mar 2004)."Suppressor of cytokine signaling 6 associates with KIT and regulates KIT receptor signaling".The Journal of Biological Chemistry.279(13): 12249–59.doi:10.1074/jbc.M313381200.PMID14707129.
- Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004)."Functional proteomics mapping of a human signaling pathway".Genome Research.14(7): 1324–32.doi:10.1101/gr.2334104.PMC442148.PMID15231748.
- Hunter MG, Jacob A, O'donnell LC, Agler A, Druhan LJ, Coggeshall KM, Avalos BR (Oct 2004)."Loss of SHIP and CIS recruitment to the granulocyte colony-stimulating factor receptor contribute to hyperproliferative responses in severe congenital neutropenia/acute myelogenous leukemia".Journal of Immunology.173(8): 5036–45.doi:10.4049/jimmunol.173.8.5036.PMID15470047.
External links[edit]
- HumanCISHgenome location andCISHgene details page in theUCSC Genome Browser.