CREBL1

ATF6B
Identifiers
Aliases	ATF6B,CREB-RP, CREBL1, G13, activating transcription factor 6 beta
External IDs	OMIM:600984;MGI:105121;HomoloGene:31238;GeneCards:ATF6B;OMA:ATF6B - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,115,264bp End 32,128,253bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.22 cM Start 34,866,120bp End 34,874,048bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in monocyte granulocyte right uterine tube left ovary right ovary right lobe of thyroid gland spleen right hemisphere of cerebellum left lobe of thyroid gland gallbladder Top expressed in yolk sac granulocyte lip dentate gyrus of hippocampal formation granule cell neural layer of retina neural tube ventricular zone thymus choroid plexus of fourth ventricle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding cAMP response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane intracellular anatomical structure integral component of endoplasmic reticulum membrane protein-DNA complex endoplasmic reticulum nucleus endomembrane system nucleolus RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II transcription, DNA-templated endoplasmic reticulum unfolded protein response ATF6-mediated unfolded protein response response to unfolded protein signal transduction transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of ATF6-mediated unfolded protein response Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 1388 12915 Ensembl ENSG00000213676 ENSG00000228628 ENSG00000234539 ENSG00000168468 ENSMUSG00000015461 UniProt Q99941 O35451 RefSeq (mRNA) NM_004381 NM_001136153 NM_017406 RefSeq (protein) NP_001129625 NP_004372 n/a Location (UCSC) Chr 6: 32.12 – 32.13 Mb Chr 17: 34.87 – 34.87 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

CAMP responsive element binding protein-like 1,also known asCREBL1,is aproteinwhich in humans is encoded by theCREBL1gene.

Function

The protein encoded by this gene bears sequence similarity with theCreb/ATF subfamily of thebZipsuperfamily oftranscription factors.It localizes to both thecytoplasmand thenucleus.The gene localizes to themajor histocompatibility complex(MHC) class III region onchromosome 6.

Further reading

• Bristow J, Tee MK, Gitelman SE, et al. (1993)."Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B".J. Cell Biol.122(1): 265–78.doi:10.1083/jcb.122.1.265.PMC2119596.PMID7686164.
• Min J, Shukla H, Kozono H, et al. (1996)."A novel Creb family gene telomeric of HLA-DRA in the HLA complex".Genomics.30(2): 149–56.doi:10.1006/geno.1995.9891.PMID8586413.
• Khanna A, Campbell RD (1996)."The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein".Biochem. J.319. ( Pt 1) (Pt 1): 81–9.doi:10.1042/bj3190081.PMC1217738.PMID8870652.
• Speek M, Barry F, Miller WL (1997)."Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes".Hum. Mol. Genet.5(11): 1749–58.doi:10.1093/hmg/5.11.1749.PMID8923003.
• Swanson DJ, Adachi M, Lewis EJ (2000)."The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein".J. Biol. Chem.275(4): 2911–23.doi:10.1074/jbc.275.4.2911.PMID10644760.
• Yoshida H, Okada T, Haze K, et al. (2001)."Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response".Mol. Cell. Biol.21(4): 1239–48.doi:10.1128/MCB.21.4.1239-1248.2001.PMC99577.PMID11158310.
• Ye J, Rawson RB, Komuro R, et al. (2001)."ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs".Mol. Cell.6(6): 1355–64.doi:10.1016/S1097-2765(00)00133-7.PMID11163209.
• Haze K, Okada T, Yoshida H, et al. (2001)."Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response".Biochem. J.355(Pt 1): 19–28.doi:10.1042/0264-6021:3550019.PMC1221707.PMID11256944.
• Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003)."Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta"(PDF).Biochem. Biophys. Res. Commun.299(3): 366–72.doi:10.1016/S0006-291X(02)02638-4.PMID12445808.Archived fromthe original(PDF)on 2020-07-12.Retrieved2020-09-05.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Okada T, Haze K, Nadanaka S, et al. (2003)."A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6".J. Biol. Chem.278(33): 31024–32.doi:10.1074/jbc.M300923200.PMID12782636.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425(6960): 805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID14574404.
• Xie T, Rowen L, Aguado B, et al. (2004)."Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse".Genome Res.13(12): 2621–36.doi:10.1101/gr.1736803.PMC403804.PMID14656967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.

External links

• CREBL1+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• HumanATF6Bgenome location andATF6Bgene details page in theUCSC Genome Browser.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.