CYP12 family
Cytochrome P450, family 12,also known asCYP12,is acytochrome P450familyfound ininsectgenomebelongs toMitochondrial clanCYPs,which is located in theinner membraneofmitochondria(IMM).[1][2]The first gene identified in this family is theCYP12A1from theMusca domestica(house fly), which is involved ininsecticide resistance.[3]CYP12A1 protein localization inmitochondriabyimmunohistochemistryand absolute dependence on mitochondrialelectron donorsadrenodoxin reductaseandadrenodoxin.[3]
RabbitgeneCYP8B1was named CYP12 at the beginning of its discovery, because it hydroxylated itssterolsubstrateon the 12 position.[4]However, CYP12 is a family of insect P450s found in mitochondria, so this gene was renamed to CYP8B1.[5]
References
[edit]- ^Nelson, DR (November 1998). "Metazoan cytochrome P450 evolution".Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology.121(1–3): 15–22.doi:10.1016/s0742-8413(98)10027-0.PMID9972448.
- ^Tijet, N; Helvig, C; Feyereisen, R (10 January 2001). "The cytochrome P450 gene superfamily in Drosophila melanogaster: annotation, intron-exon organization and phylogeny".Gene.262(1–2): 189–98.doi:10.1016/s0378-1119(00)00533-3.PMID11179683.
- ^abGuzov, VM; Unnithan, GC; Chernogolov, AA; Feyereisen, R (15 November 1998). "CYP12A1, a mitochondrial cytochrome P450 from the house fly".Archives of Biochemistry and Biophysics.359(2): 231–40.doi:10.1006/abbi.1998.0901.PMID9808765.
- ^Eggertsen, G; Olin, M; Andersson, U; Ishida, H; Kubota, S; Hellman, U; Okuda, KI; Björkhem, I (13 December 1996)."Molecular cloning and expression of rabbit sterol 12alpha-hydroxylase".The Journal of Biological Chemistry.271(50): 32269–75.doi:10.1074/jbc.271.50.32269.PMID8943286.S2CID84628848.
- ^Nelson, DR (2006). "Cytochrome P450 Nomenclature, 2004".Cytochrome P450 Protocols.Methods in Molecular Biology. Vol. 320. pp. 1–10.doi:10.1385/1-59259-998-2:1.ISBN1-59259-998-2.PMID16719369.
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