Calcitonin receptor
Thecalcitonin receptor(CT) is aG protein-coupled receptorthat binds the peptide hormonecalcitoninand is involved in maintenance ofcalciumhomeostasis,[5]particularly with respect to bone formation and metabolism.[6][7][8]
CT works by activating theG-proteinsGsandGqoften found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain.[9]It may also affect the ovaries in women and the testes in men.
The function of the CT receptor protein is modified through its interaction withReceptor activity-modifying proteins(RAMPs), forming the multimericamylin receptorsAMY1(CT + RAMP1), AMY2(CT + RAMP2), and AMY3(CT+ RAMP3).[10]
Preclinical studies have suggested thatdual amylin and calcitonin receptor agonistsmay be more effective thanamylin receptoragonists for obesity andtype II diabetes.[11]
Interactions
[edit]![](https://upload.wikimedia.org/wikipedia/commons/thumb/f/f0/Human_calcitonin_recptor-Gs_complex_PDB_7TYO.png/220px-Human_calcitonin_recptor-Gs_complex_PDB_7TYO.png)
Calcitonin receptor has been shown tointeractwithApolipoprotein B[12][13]andLRP1.[14]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000004948–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000023964–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Purdue BW, Tilakaratne N, Sexton PM (2002). "Molecular pharmacology of the calcitonin receptor".Receptors & Channels.8(3–4): 243–55.doi:10.1080/10606820213681.PMID12529940.
- ^Chambers TJ, Magnus CJ (January 1982). "Calcitonin alters behaviour of isolated osteoclasts".The Journal of Pathology.136(1): 27–39.doi:10.1002/path.1711360104.PMID7057295.S2CID8395420.
- ^Dacquin R, Davey RA, Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (February 2004)."Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo".The Journal of Cell Biology.164(4): 509–14.doi:10.1083/jcb.200312135.PMC2171986.PMID14970190.
- ^Davey RA, Turner AG, McManus JF, Chiu WS, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C, Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (August 2008)."Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice".Journal of Bone and Mineral Research.23(8): 1182–93.doi:10.1359/jbmr.080310.PMC2680171.PMID18627265.
- ^senselabArchivedFebruary 28, 2009, at theWayback Machine
- ^"Calcitonin Receptors: Introduction".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-12.
- ^Sonne N, Karsdal MA, Henriksen K (1 April 2021)."Mono and dual agonists of the amylin, calcitonin, and CGRP receptors and their potential in metabolic diseases".Molecular Metabolism.46:101109.doi:10.1016/j.molmet.2020.101109.ISSN2212-8778.PMC8085567.PMID33166741.
- ^Zhang J, Herscovitz H (February 2003)."Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B".The Journal of Biological Chemistry.278(9): 7459–68.doi:10.1074/jbc.M207976200.PMID12397072.
- ^Linnik KM, Herscovitz H (August 1998)."Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state".The Journal of Biological Chemistry.273(33): 21368–73.doi:10.1074/jbc.273.33.21368.PMID9694898.
- ^Orr AW, Pedraza CE, Pallero MA, Elzie CA, Goicoechea S, Strickland DK, Murphy-Ullrich JE (June 2003)."Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly".The Journal of Cell Biology.161(6): 1179–89.doi:10.1083/jcb.200302069.PMC2172996.PMID12821648.
Further reading
[edit]- Pondel M (December 2000)."Calcitonin and calcitonin receptors: bone and beyond".International Journal of Experimental Pathology.81(6): 405–22.doi:10.1046/j.1365-2613.2000.00176.x.PMC2517743.PMID11298188.
- Gorn AH, Lin HY, Yamin M, Auron PE, Flannery MR, Tapp DR, Manning CA, Lodish HF, Krane SM, Goldring SR (November 1992)."Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line".The Journal of Clinical Investigation.90(5): 1726–35.doi:10.1172/JCI116046.PMC443230.PMID1331173.
- Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K (December 1995). "Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene".Endocrinology.136(12): 5377–84.doi:10.1210/endo.136.12.7588285.PMID7588285.
- Egerton M, Needham M, Evans S, Millest A, Cerillo G, McPheat J, Popplewell M, Johnstone D, Hollis M (April 1995). "Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization".Journal of Molecular Endocrinology.14(2): 179–89.doi:10.1677/jme.0.0140179.PMID7619207.
- Nussenzveig DR, Mathew S, Gershengorn MC (May 1995). "Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor".Endocrinology.136(5): 2047–51.doi:10.1210/endo.136.5.7720653.PMID7720653.
- Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). "A new type of human calcitonin receptor isoform generated by alternative splicing".Biochemical and Biophysical Research Communications.209(2): 744–51.doi:10.1006/bbrc.1995.1562.PMID7733946.
- Pérez Jurado LA, Li X, Francke U (1995). "The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome".Cytogenetics and Cell Genetics.70(3–4): 246–9.doi:10.1159/000134044.PMID7789182.
- Nussenzveig DR, Thaw CN, Gershengorn MC (November 1994)."Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes".The Journal of Biological Chemistry.269(45): 28123–9.doi:10.1016/S0021-9258(18)46903-7.PMID7961748.
- Kuestner RE, Elrod RD, Grant FJ, Hagen FS, Kuijper JL, Matthewes SL, O'Hara PJ, Sheppard PO, Stroop SD, Thompson DL (August 1994). "Cloning and characterization of an abundant subtype of the human calcitonin receptor".Molecular Pharmacology.46(2): 246–55.PMID8078488.
- Frendo JL, Pichaud F, Mourroux RD, Bouizar Z, Segond N, Moukhtar MS, Jullienne A (April 1994)."An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid".FEBS Letters.342(2): 214–6.Bibcode:1994FEBSL.342..214F.doi:10.1016/0014-5793(94)80503-2.PMID8143880.S2CID5709002.
- Masi L, Becherini L, Gennari L, Colli E, Mansani R, Falchetti A, Cepollaro C, Gonnelli S, Tanini A, Brandi ML (April 1998). "Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women".Biochemical and Biophysical Research Communications.245(2): 622–6.doi:10.1006/bbrc.1998.8445.PMID9571205.
- Taboulet J, Frenkian M, Frendo JL, Feingold N, Jullienne A, de Vernejoul MC (December 1998)."Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women".Human Molecular Genetics.7(13): 2129–33.doi:10.1093/hmg/7.13.2129.PMID9817931.
- Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM (July 1999). "Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product".Molecular Pharmacology.56(1): 235–42.doi:10.1124/mol.56.1.235.PMID10385705.
- Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (September 1999)."A novel calcitonin receptor gene in human osteoclasts from normal bone marrow".FEBS Letters.458(3): 409–14.Bibcode:1999FEBSL.458..409N.doi:10.1016/S0014-5793(99)01176-X.PMID10570950.S2CID41350895.
- Beaudreuil J, Taboulet J, Orcel P, Graulet AM, Denne MA, Baudoin C, Jullienne A, De Vernejoul MC (July 2000). "Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement".Bone.27(1): 161–8.doi:10.1016/S8756-3282(00)00305-7.PMID10865224.
- Wada S, Yasuda S, Nagai T, Maeda T, Kitahama S, Suda S, Findlay DM, Iitaka M, Katayama S (April 2001)."Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor".Endocrinology.142(4): 1471–8.doi:10.1210/endo.142.4.8085.PMID11250927.
- Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM (September 2001)."C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells".The Journal of Experimental Medicine.194(6): 781–95.doi:10.1084/jem.194.6.781.PMC2195958.PMID11560994.
- Nosaka Y, Tachi Y, Shimpuku H, Kawamura T, Ohura K (2002). "Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants".The International Journal of Oral & Maxillofacial Implants.17(1): 38–43.PMID11858573.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proceedings of the National Academy of Sciences of the United States of America.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
External links
[edit]- "Calcitonin Receptors".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2007-07-23.
- Calcitonin+receptorsat the U.S. National Library of MedicineMedical Subject Headings(MeSH)