CatSper2
CatSper2,is aproteinwhich in humans is encoded by theCATSPER2gene.[5][6]CatSper2 is a member of thecation channels of spermfamily of protein. The four proteins in this family together form aCa2+-permeantion channelspecific essential for the correct function of sperm cells.[7]
Function[edit]
Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific tospermatozoaand localize to theflagellum.The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q15; the second copy of this gene is thought to be apseudogene.[8]
See also[edit]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000166762–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000033486–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Quill TA, Ren D, Clapham DE, Garbers DL (October 2001)."A voltage-gated ion channel expressed specifically in spermatozoa".Proc. Natl. Acad. Sci. U.S.A.98(22): 12527–31.Bibcode:2001PNAS...9812527Q.doi:10.1073/pnas.221454998.PMC60087.PMID11675491.
- ^Clapham DE, Garbers DL (December 2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacol. Rev.57(4): 451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
- ^*"CatSper and Two-Pore Channels: Introduction".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology.
- ^"Entrez Gene: CatSper2".
Further reading[edit]
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Zhang D, Chen J, Saraf A, et al. (2006)."Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity".J. Biol. Chem.281(31): 22332–41.doi:10.1074/jbc.M511288200.PMID16740636.
- Garbers DL (2001). "Ion channels. Swimming with sperm".Nature.413(6856): 579, 581–2.Bibcode:2001Natur.413..579G.doi:10.1038/35098164.PMID11595929.S2CID6099942.
- Quill TA, Ren D, Clapham DE, Garbers DL (2001)."A voltage-gated ion channel expressed specifically in spermatozoa".Proc. Natl. Acad. Sci. U.S.A.98(22): 12527–31.Bibcode:2001PNAS...9812527Q.doi:10.1073/pnas.221454998.PMC60087.PMID11675491.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
- Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels".Pharmacol. Rev.57(4): 451–4.doi:10.1124/pr.57.4.7.PMID16382101.S2CID35096827.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.
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