Centrum (multivitamin)
Product type | Multivitamins |
---|---|
Owner | Haleon |
Country | United States |
Introduced | 1978 |
Previous owners | |
Website | www |
Centrumis an American brand ofmultivitaminsproduced byHaleon.It was previously owned byPfizer(formerlyWyeth) andGSK.[1]
Physicians' Health Study II[edit]
This sectionmay be too technical for most readers to understand.(January 2013) |
In 2012, the Physicians' Health Study II (PHS-II) found that participants who took a Centrum-brand multivitamin each day for an average of 11 years had no change in cancer mortality or cardiovascular disease mortality compared to the placebo group. The authors did find a slight reduction in cancer incidence although this conclusion was questioned in theJournal of the American Medical Association.[2]
On October 17, 2012, researchers reported on adouble-blind studyof 14,641 male U.S. physicians initially aged 50 years or older (mean age of 64.3, standard deviation 9.2 years), that began in 1997 with treatment and follow-up through June 1, 2011. They compared total cancer (excludingnonmelanoma skin cancer) for participants taking a daily multivitamin (Centrum Silver byPfizer) versusplacebo.Compared with placebo, men taking a daily multivitamin had astatistically significantreduction in the incidence of total cancer, with ahazard ratio(HR) = 0.92 (95%confidence interval(CI) 0.86-0.998; P =.04). No statistically significant effects were found for any specific cancers or cancer mortality. The 95% CI of the hazard ratio implied a benefit of between 14% and.2% over placebo. In absolute terms the difference was 1.3 cancer diagnoses, per 1000 years of life (18.3-17 events, respectively). The median follow up time was 11.2 years.[3]The paper's co-principal investigator,Dr. J. Michael Gaziano, acardiologist,was quoted byThe New York Timesas saying "it certainly appears there is a modest reduction in the risk of cancer from a typical multivitamin."[4]The study was also featured inThe Wall Street Journalon October 17, 2012.[5]
An editorial in the same issue of theJournal of the American Medical Association(JAMA), reflecting the opinion of JAMA, was dismissive of the report on several counts. First, they said, "it seems unlikely that a common characteristic across all diseases included under this wide category of cancer would be a protective effect from multivitamins", suggesting if no specific cancer was effected, why would general cancer risk be so affected. Second, they questioned the study's abilities to deliver on the question of whether a multivitamin would be protective in a well-nourished population (Bayesian probability) stating: "The plausibility of a protective effect is reduced by the absence of a clear path through which 30 different vitamins and minerals would cause a decline in the risk of multiple cancers and, especially, by the negative pattern of prior results." In addition the investigators observed no difference in effect whether the study participants were or were not adherent to the multivitamin intervention, which diminishes thedose–response relationship.[2]
The editorial was critical of the statistical multiplicity (multiple comparisons): the complete planned analysis of the primary and secondary end points in the PHS II study would entail 28 tests of association; each of which has "some possibility of yielding a statistically significant result by chance alone, even when there is no true treatment effect. [...] when this finding is considered in the context of the number of already completed and planned analyses of the same study, the strength of the inference is weaker, because the likelihood of a randomly occurring finding [...] is much greater." They concluded that any of the conventional P value corrections for multiple comparisons would eliminate the apparent "statistical significance" of the results.[2]
From the same double-blind study, they found that taking a daily multivitamin did not have any effect in reducingheart attacksand other major cardiovascular events, MI, stroke, and CVD mortality.[6]
Contains[edit]
Incomplete list of the nutritional facts for each type of Centrum brand vitamin:
Centrum Mens[edit]
Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%) |
---|---|---|---|---|
Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene) |
Vitamin C | 90,000 | 90 | 0.09 | 100 |
Vitamin D3 | 25 | 0.025 | 0.000025 | 125 |
Vitamin E | 20,300 | 20.3 | 0.0203 | 135 |
Vitamin K | 60 | 0.060 | 0.000006 | 50 |
Thiamin | 1,200 | 1.2 | 0.0012 | 100 |
Riboflavin | 1,300 | 1.3 | 0.0013 | 100 |
Niacin | 16,000 | 16 | 0.016 | 100 |
Vitamin B6 | 2,000 | 2 | 0.002 | 118 |
Folate | 333 | 0.333 | 0.000333 | 83 |
Vitamin B12 | 6 | 0.006 | 0.00006 | 250 |
Biotin | 40 | 0.04 | 0.0004 | 133 |
Pantothenic Acid | 15,000 | 15 | 0.015 | 300 |
Calcium | 210,000 | 210 | 0.21 | 16 |
Iron | 8,000 | 8 | 0.008 | 44 |
Phosphorus | 20,000 | 20 | 0.02 | 2 |
Iodine | 150 | 0.15 | 0.00015 | 100 |
Magnesium | 100,000 | 100 | 0.1 | 24 |
Zinc | 11,000 | 11 | 0.01 | 100 |
Selenium | 100 | 0.1 | 0.0001 | 182 |
Copper | 900 | 0.9 | 0.0009 | 100 |
Manganese | 2,300 | 2.3 | 0.0023 | 100 |
Chromium | 35 | 0.035 | 0.000035 | 100 |
Molybdenum | 50 | 0.05 | 0.00005 | 111 |
Chloride | 7,2000 | 72 | 0.072 | 3 |
Potassium | 8,000 | 80 | 0.08 | 2 |
Lycopene | 600 | 0.6 | 0.0006 | NE |
NE = Not Established
Centrum Womens[edit]
Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%) |
---|---|---|---|---|
Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene) |
Vitamin C | 75,000 | 75 | 0.075 | 83 |
Vitamin D3 | 25 | 0.025 | 0.000025 | 125 |
Vitamin E | 15,800 | 15.8 | 0.0203 | 105 |
Vitamin K | 50 | 0.050 | 0.000005 | 42 |
Thiamin | 1,100 | 1.1 | 0.0011 | 92 |
Riboflavin | 1,100 | 1.1 | 0.0011 | 85 |
Niacin | 14,000 | 14 | 0.014 | 88 |
Vitamin B6 | 2,000 | 2 | 0.002 | 118 |
Folate | 667 | 0.667 | 0.000667 | 167 |
Vitamin B12 | 6 | 0.006 | 0.00006 | 250 |
Biotin | 40 | 0.04 | 0.0004 | 133 |
Pantothenic Acid | 15,000 | 15 | 0.015 | 300 |
Calcium | 200,000 | 200 | 0.20 | 15 |
Iron | 18,000 | 18 | 0.018 | 100 |
Phosphorus | 20,000 | 20 | 0.02 | 2 |
Iodine | 150 | 0.15 | 0.00015 | 100 |
Magnesium | 100,000 | 100 | 0.1 | 24 |
Zinc | 8,000 | 8 | 0.08 | 24 |
Selenium | 18 | 0.018 | 0.0000018 | 33 |
Copper | 00 | 0.5 | 0.0005 | 56 |
Manganese | 1,800 | 1.8 | 0.0018 | 78 |
Chromium | 32 | 0.032 | 0.000032 | 91 |
Molybdenum | 50 | 0.05 | 0.00005 | 111 |
Chloride | 7,2000 | 72 | 0.072 | 3 |
Potassium | 8,000 | 80 | 0.08 | 2 |
Centrum Adults[edit]
Vitamin | micrograms (mcg) | milligrams (mg) | grams (g) | Daily Value (%) |
---|---|---|---|---|
Vitamin A | 1,050 | 1.05 | 0.00105 | 117 (29% as β-Carotene) |
Vitamin C | 60,000 | 60 | 0.06 | 67 |
Vitamin D3 | 25 | 0.025 | 0.000025 | 125 |
Vitamin E | 13,500 | 13.5 | 0.0135 | 90 |
Vitamin K | 25 | 0.025 | 0.0000025 | 21 |
Thiamin | 1,500 | 1.5 | 0.0015 | 125 |
Riboflavin | 1,700 | 1.7 | 0.0017 | 100 |
Niacin | 20,000 | 20 | 0.020 | 125 |
Vitamin B6 | 2,000 | 2 | 0.002 | 118 |
Folate | 667 | 0.667 | 0.000667 | 167 |
Vitamin B12 | 6 | 0.006 | 0.00006 | 250 |
Biotin | 30 | 0.03 | 0.0003 | 100 |
Pantothenic Acid | 10,000 | 10 | 0.010 | 200 |
Calcium | 200,000 | 200 | 0.20 | 15 |
Iron | 18,000 | 18 | 0.0018 | 100 |
Phosphorus | 20,000 | 20 | 0.02 | 2 |
Iodine | 150 | 0.15 | 0.00015 | 100 |
Magnesium | 50,000 | 50 | 0.050 | 12 |
Zinc | 11,000 | 11 | 0.01 | 100 |
Selenium | 55 | 0.055 | 0.000055 | 100 |
Copper | 500 | 0.5 | 0.0005 | 56 |
Manganese | 2,300 | 2.3 | 0.0023 | 100 |
Chromium | 35 | 0.035 | 0.000035 | 100 |
Molybdenum | 45 | 0.045 | 0.000045 | 100 |
Chloride | 7,2000 | 72 | 0.072 | 3 |
Potassium | 8,000 | 80 | 0.08 | 2 |
References[edit]
- ^"Wyeth sued by teachers group over Centrum ads".National Post.2003-09-18. p. 2.
- ^abcBach, Peter B.; Lewis, Roger J. (14 November 2012). "Multiplicities in the Assessment of Multiple Vitamins Is It Too Soon to Tell Men That Vitamins Prevent Cancer?".The Journal of the American Medical Association.308(18): 1916–1917.doi:10.1001/jama.2012.53273.PMID23150011.
- ^Gaziano, J. Michael; Sesso, Howard D.; Christen, William G.; Bubes, Vadim; Smith, Joanne P.; MacFadyen, Jean; Schvartz, Miriam; Manson, JoAnn E.; Glynn, Robert J.; Buring, Julie E. (October 17, 2012)."Multivitamins in the Prevention of Cancer in Men - The Physicians' Health Study II Randomized Controlled Trial".JAMA.308(18): 1871–80.doi:10.1001/jama.2012.14641.PMC3517179.PMID23162860.
- ^Rabin, Roni Caryn (October 17, 2012)."Daily Multivitamin May Reduce Cancer Risk, Clinical Trial Finds".The New York Times.Archivedfrom the original on October 18, 2012.RetrievedOctober 17,2012.
- ^Winslow, Ron (18 October 2012)."Multivitamin Cuts Cancer Risk, Large Study Finds".The Wall Street Journal.Archivedfrom the original on 22 December 2015.Retrieved13 December2012.
- ^Sesso, Howard D.; Christen, William G.; Bubes, Vadim; Smith, Joanne P.; MacFadyen, Jean; Schvartz, Miriam; Manson, JoAnn E.; Glynn, Robert J.; Buring, Julie E.; Gaziano, J. Michael (November 7, 2012)."Multivitamins in the Prevention of Cardiovascular Disease in Men - The Physicians' Health Study II Randomized Controlled Trial".JAMA.308(17): 1751–60.doi:10.1001/jama.2012.14805.PMC3501249.PMID23117775.
- ^https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000770-web-ready-centrum-men-tablets-(version-2).pdfArchived2021-04-25 at theWayback Machine[bare URL PDF]
- ^https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000773-web-ready-centrum-women-(version-2).pdfArchived2021-04-25 at theWayback Machine[bare URL PDF]
- ^https://www.centrum.com/content/dam/cf-consumer-healthcare/bp-wellness-centrum/en_US/pdf/lbl-00000767-web-ready-centrum-adults-(version-2).pdfArchived2021-04-25 at theWayback Machine[bare URL PDF]