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Charles Brenton Huggins

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"Charles Huggins" redirects here. For the politician, seeCharlie Huggins.
Charles Brenton Huggins
Huggins in 1966
Born(1901-09-22)September 22, 1901
Halifax,Nova Scotia,Canada
DiedJanuary 12, 1997(1997-01-12)(aged 95)
Chicago, Illinois,U.S.
CitizenshipCanadian, American
Alma materAcadia University
Harvard University
Known forprostate cancer
hormones
AwardsNobel Prize for Physiology or Medicine(1966)
Cameron Prize for Therapeutics of the University of Edinburgh(1956)
Gairdner Foundation International Award(1966)
Scientific career
Fieldsphysiology
InstitutionsUniversity of Michigan,University of Chicago

Charles Brenton Huggins(September 22, 1901 – January 12, 1997) was a Canadian-American surgeon and physiologist known for his work onprostatefunction,prostate cancer,andbreast cancer.Born inHalifaxin 1901, Huggins moved to the United States for medical school. He was one of the founding staff members of theUniversity of Chicago Medical School,where he remained for the duration of his professional research career. Huggins' work on howsex hormonesinfluence prostate function ultimately led to his discovery of hormone therapies to treat prostate cancer. For this finding, he was awarded the 1966Nobel Prize for Physiology or Medicine.In addition to his work on prostate cancer, Huggins explored the relationship between hormones and breast cancer, developed ananimal modelfor breast cancer, and developed "chromogenic substrate" s that are widely used for biochemical analyses. Huggins continued to perform research into his 90s; he died inChicagoin 1997.

Early life and education

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Charles Brenton Huggins was born September 22nd, 1901 inHalifax,Nova Scotiato Charles E. Huggins and Bessie Maria Spencer.[1][2]At 19, he graduated fromAcadia Universitywith aBAdegree, supplementing his Acadia coursework with summer courses in physical and organic chemistry atColumbia University.[3][1]Huggins went on toHarvard Medical School,and received hisMDdegree in 1924. He served his internship and residency in general surgery withFrederick A. Collerat theUniversity of Michigan.[3]While at Michigan, Huggins met operating room nurse Margaret Wellman; they married in 1927.[1]

Academic career

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In 1927, Huggins was recruited to the newUniversity of Chicago Medical Schoolby chairman of surgeryDallas Phemister.As one of the eight original staff members of the school, Huggins was assigned theurologydepartment, and had to rapidly teach himself the specialty.[1]In 1931, Phemister offered Huggins a paid research sabbatical in Europe; Huggins spent several months at London'sLister Instituteworking inRobert Robison's lab to deepen his knowledge in biochemistry.[1][4]He was promoted toassociate professorin 1933, and fullprofessorin 1936.[2]

In 1951, businessman and longtime financial supporter of Huggins' researchBen E. Mayendowed the Ben May Laboratory for Cancer Research at the University of Chicago. Huggins eventually became the May Laboratory's director, serving in the position until 1969. In 1962, he was granted anendowed professorship,the William B. Ogden Distinguished Service Professor.[1]

Notable students of Professor Huggins included Howard Guy Williams-Ashman, Shutsung Liao,Paul TalalayandA. Hari Reddi.[5][6]

Research

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A plaque in Professor's Huggins office carried his motto: "Discovery is our business."[7]This motto signified his ethos to research and medical discovery.

Huggins' early research work focused on bone physiology. However, he eventually felt this bone work was unlikely to lead to medical progress, and set it aside in favor of studying the male urogenital tract. Through the 1930s, Huggins published work characterizing the constituents ofsemenand which organ (seminal vesiclesor prostate) they derive from.[8]In 1939, Huggins described a method for isolating prostate fluid from dogs, which served as the foundation for much of his subsequent work.[8]He showed that the prostate requires androgens (male sex hormones) in order to function, and that androgen treatment could be counteracted by treatment with estrogens.[8]In the course of this work, he discovered that older dogs tended to have enlarged prostates, and that these enlarged prostates could be shrunk by administering estrogen.[1][8]

In 1940 and 1941, Huggins – along with studentsClarence V. HodgesandWilliam Wallace Scott– published a series of three papers detailing his most famous finding: that counteracting androgen activity byorchiectomy(surgical removal of the testicles) or estrogen treatment shrunk tumors in many men with metastatic prostate cancer.[3][8]These men experienced dramatic pain relief within days of the treatment; four of the original 21 treated went on to survive more than 12 years from the original treatment.[3]

Huggins' work on prostate cancer often necessitated measuring the amount of prostate-derived enzymes in the blood. To this end, Huggins developedcolorimetric methodsfor quantifying the concentration of variousphosphatases,glucuronidases,andesterases.These assays relied on "chromogenic substrates" (substances that change color in response to a given enzyme), a term Huggins coined, and a concept he pioneered.[8]

In the 1950s, Huggins went on to show an analogous relationship between sex hormones and breast cancer – tumor growth was stimulated by estrogens, and slowed by androgens. At the time breast cancer research was hindered by the lack of ananimal model.Huggins described the first reliable model:7,12-dimethylbenz(a)anthraceneadministered orally to rats, 100% of which rapidly developed breast tumors; the model is now called "Huggins Tumor".[1]Around this time, Huggins wound down his surgical practice, turning his attention to full-time scientific research.[3]

Altogether, Huggins published over 200 peer-reviewed papers describing his research.[1]

Honors

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Huggins was elected to the United StatesNational Academy of Sciencesand theAmerican Academy of Arts and Sciencesin 1949.[9][10]In 1962, he was elected to theAmerican Philosophical Society,[11]and was awarded theLasker Awardthe following year. In 1966, following nominations from noted surgeonJ. Hartwell Harrisonas well as Nobel laureatesOtto H. Warburg,William P. Murphy,andAlbert Szent-Györgyi,Huggins was awarded theNobel Prize in Physiology or Medicine"for his discoveries concerning hormonal treatment of prostatic cancer".[12][2]From 1972–1979, Huggins was named the ceremonialchancellorof his alma mater, Acadia University.[3]His prize, shared with fellow cancer researcherPeyton Rous,was just the second Nobel for cancer treatment or research.[13]

Personal life

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Huggins and his wife Margaret had a son and a daughter. His son, Charles E. Huggins, was also a surgeon, and directed the Massachusetts General Hospital blood bank until his death in 1990. Margaret Huggins died in 1983.[1]Huggins devoted much of his time to laboratory work, logging long hours in the lab, and continuing to perform hands-on laboratory work in his 90s. Huggins died on January 12, 1997, inChicago, Illinois,aged 95.[1]

References

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  1. ^abcdefghijkForster, R E (June 1999). "Charles Brenton Huggins (22 September 1901–12 January 1997)".Proceedings of the American Philosophical Society.143(2): 325–31.JSTOR3181942.PMID11623829.
  2. ^abc"Charles B. Huggins".Nobel Lectures, Physiology or Medicine 1963–1970.Elsevier. 1972.Retrieved3 January2024.
  3. ^abcdef"Charles B. Huggins, MD, 1901–1997".University of Chicago Medicine 1997 Press Releases.University of Chicago. 12 January 1997. Archived fromthe originalon 21 June 2010.Retrieved8 September2015.
  4. ^"Classics in oncology. Charles Brenton Huggins".CA: A Cancer Journal for Clinicians.22(4): 230–1. 1972.doi:10.3322/canjclin.22.4.230.PMID4625048.S2CID221547609.
  5. ^"DR. HOWARD GUY WILLIAMS-ASHMAN, 78".Chicago Tribune. 3 June 2004.Retrieved17 June2024.
  6. ^"Paul Talalay, Hopkins Researcher Famed for Finding Cancer-Preventing Compound in Broccoli, Dies".Johns Hopkins Medicine.Retrieved17 June2024.
  7. ^"Charles B. Huggins, MD, 1901-1997".The University of Chicago. 13 January 1997.
  8. ^abcdefTalalay P (June 1965). "The Scientific Contributions of Charles Brenton Huggins".JAMA.192:1137–40.doi:10.1001/jama.1965.03080260025007.PMID14301033.
  9. ^"Charles B. Huggins".www.nasonline.org.Retrieved2022-11-15.
  10. ^"Charles Brenton Huggins".American Academy of Arts & Sciences.Retrieved2022-11-15.
  11. ^"APS Member History".search.amphilsoc.org.Retrieved2022-11-15.
  12. ^Hansson N, Moll F, Schultheiss D, Krischel M (June 2016). "Remembering Charles B. Huggins' Nobel Prize for Hormonal Treatment of Prostatic Cancer at its 50th Anniversary".Eur Urol.69(6): 971–2.doi:10.1016/j.eururo.2016.01.030.PMID26838478.
  13. ^Altman, Lawrence K. (January 15, 1997),"C. B. Huggins Dies at 95; Won Nobel for Cancer Work",The New York Times,retrievedOctober 13,2017
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