Class II PI 3-kinases

Class II PI 3-kinasesare a subgroup of the enzyme family,phosphoinositide 3-kinasethat share a common protein domain structure, substrate specificity and method of activation.

Class II PI 3-kinases were the most recently identified class of PI 3-kinases.

There are three class II PI 3-kinase isoforms expressed in mammalian cells;

PI3K-C2α encoded by thePIK3C2Agene
PI3K-C2β encoded by thePIK3C2Bgene
PI3K-C2γ encoded by thePIK3C2Ggene

References

[edit]

Stein RC (September 2001). "Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment".Endocrine-Related Cancer.8(3): 237–248.doi:10.1677/erc.0.0080237.PMID 11566615.
Foster FM, Traer CJ, Abraham SM, Fry MJ (August 2003). "The phosphoinositide (PI) 3-kinase family".Journal of Cell Science.116(Pt 15): 3037–3040.doi:10.1242/jcs.00609.PMID 12829733.
Vanhaesebroeck B, Waterfield MD (November 1999). "Signaling by distinct classes of phosphoinositide 3-kinases".Experimental Cell Research.253(1): 239–254.doi:10.1006/excr.1999.4701.PMID 10579926.

Transferases:phosphorus-containing groups (EC2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1:OHacceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2:COOHacceptor	Phosphoglycerate Aspartate kinase
2.7.3:Nacceptor	Creatine
2.7.4:PO₄acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6:diphosphotransferase
(P₂O₇)

2.7.7:nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I/A γ θ ν T7 Taq II/B α δ ε ζ Pfu III/C IV/X β λ μ TDT V/Y η ι κ RNA-directed DNA polymerase Reverse transcriptase Telomerase
RNA polymerase	Template-directed RNA polymerase I II III IV V ssRNAP POLRMT Primase 1 2 PrimPol RNA-dependent RNA polymerase Polyadenylation PAP PNPase

Phosphorolytic
3' to 5'exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8:miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13:protein kinase
(PO₄;protein acceptor)

2.7.10:protein-tyrosine	seetyrosine kinases
2.7.11:protein-serine/threonine	seeserine/threonine-specific protein kinases
2.7.12:protein-dual-specificity	seeserine/threonine-specific protein kinases
2.7.13:protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1Oxidoreductases(list) EC2Transferases(list) EC3Hydrolases(list) EC4Lyases(list) EC5Isomerases(list) EC6Ligases(list) EC7Translocases(list)

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See also

References