Clidinium bromide

Clidinium bromide
Clinical data
AHFS/Drugs.com	Monograph
MedlinePlus	a601036
Routes of; administration	Oral
ATC code	A03CA02(WHO) (combination with psycholeptics);
Legal status
Legal status	US:℞-only;
Pharmacokineticdata
Bioavailability	Low
Excretion	Renaland biliary
Identifiers
	IUPAC name 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-1-azabicyclo[2.2.2]octan-1-ium bromide;
CAS Number	7020-55-53485-62-9;
PubChemCID	2784;
IUPHAR/BPS	366;
DrugBank	DB00771;
ChemSpider	2682;
UNII	BO76JF850N;
KEGG	D00716;
ChEMBL	ChEMBL1200950;
CompTox Dashboard(EPA)	DTXSID6045379;
Chemical and physical data
Formula	C22H26NO3+
Molar mass	352.454g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(OC2C1CC[N+](CC1)(C)C2)C(O)(c3ccccc3)c4ccccc4;
	InChI InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1; Key:HOOSGZJRQIVJSZ-UHFFFAOYSA-N;
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Clidinium bromide(INN) is ananticholinergic(specifically amuscarinic antagonist)drug.^[1]^[2]It may help symptoms of cramping and abdominal/stomach pain by decreasingstomach acid,and slowing the intestines. It is commonly prescribed in combination withchlordiazepoxide(abenzodiazepinederivative) using the brand nameNormaxin.

Uses

Peptic ulcer disease

Used in fixed combination with chlordiazepoxide as adjunctive therapy in the treatment of peptic ulcer disease; however, no conclusive data that antimuscarinics aid in the healing, decrease the rate of recurrence, or prevent complications of peptic ulcers.^[3]

With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.

GI motility disturbances

Used in fixed combination with chlordiazepoxide in the treatment of functional GI motility disturbances (e.g., irritable bowel syndrome).

Has limited efficacy in treatment of GI motility disturbance and should only be used if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.

Acute enterocolitis

Used in fixed combination withchlordiazepoxidein the treatment of acuteenterocolitis.However,antimuscarinicsshould be used with extreme caution in patients with diarrhea orulcerative colitis.

Mechanism of action

Clidinium inhibitsmuscarinic acetylcholine receptorsonsmooth muscles,secretory glands,and in thecentral nervous systemto relaxsmooth muscleand decreasebiliary tractsecretions.^[4]

References

^"Clidinium bromide".Drugs.com.RetrievedAugust 24,2013.
^Aronson JK (2016)."Clidinium bromide".Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions(Sixteenth ed.). Amsterdam: Elsevier. p. 404.ISBN 978-0-444-53716-4.
^"Clidinium Bromide Monograph".Drugs.com.RetrievedAugust 24,2013.
^"Clidinium bromide".2014 Nurse's Drug Handbook(13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246.ISBN 978-1-284-03115-7.

External links

[1] "Clidinium bromide".Drugs.com.RetrievedAugust 24,2013.

[Aronson_2016-2] Aronson JK (2016)."Clidinium bromide".Meyler's side effects of drugs: the international encyclopedia of adverse drug reactions and interactions(Sixteenth ed.). Amsterdam: Elsevier. p. 404.ISBN 978-0-444-53716-4.

[3] "Clidinium Bromide Monograph".Drugs.com.RetrievedAugust 24,2013.

[jones_and_bartlett-4] "Clidinium bromide".2014 Nurse's Drug Handbook(13th ed.). Burlington, MA: Jones & Bartlett Learning. 2013. pp. 245–246.ISBN 978-1-284-03115-7.

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