Cyclin E1

CCNE1
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 1W98
Identifiers
Aliases	CCNE1,CCNE, pcyclin E1
External IDs	OMIM:123837;MGI:88316;HomoloGene:14452;GeneCards:CCNE1;OMA:CCNE1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q12 Start 29,811,991bp End 29,824,312bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 25.35 cM Start 37,797,409bp End 37,806,959bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in secondary oocyte placenta testicle decidua bone marrow left testis right testis amniotic fluid gingival epithelium mucosa of transverse colon Top expressed in embryo epiblast morula condyle fossa internal carotid artery fetal liver hematopoietic progenitor cell primitive streak embryo mandibular prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription coactivator activity kinase activity cyclin-dependent protein serine/threonine kinase regulator activity protein binding androgen receptor binding protein kinase binding cyclin-dependent protein serine/threonine kinase activity protein kinase activity Cellular component cytosol cyclin-dependent protein kinase holoenzyme complex nucleoplasm nucleus cyclin E1-CDK2 complex cytoplasm centrosome Biological process androgen receptor signaling pathway Wnt signaling pathway regulation of transcription involved in G1/S transition of mitotic cell cycle regulation of cell cycle cell division positive regulation of transcription, DNA-templated protein phosphorylation DNA replication initiation cell cycle regulation of protein kinase activity negative regulation of transcription by RNA polymerase II telomere maintenance homologous chromosome pairing at meiosis chromosome organization involved in meiotic cell cycle G1/S transition of mitotic cell cycle regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle regulation of mitotic nuclear division positive regulation of cell population proliferation positive regulation of cell cycle positive regulation of G1/S transition of mitotic cell cycle mitotic cell cycle phase transition Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 898 12447 Ensembl ENSG00000105173 ENSMUSG00000002068 UniProt P24864 Q61457 RefSeq (mRNA) NM_001238 NM_057182 NM_001322259 NM_001322261 NM_001322262 NM_007633 RefSeq (protein) NP_001229 NP_001309188 NP_001309190 NP_001309191 NP_001309188.1 NP_001309190.1 NP_031659 Location (UCSC) Chr 19: 29.81 – 29.82 Mb Chr 7: 37.8 – 37.81 Mb PubMedsearch
Wikidata
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G1/S-specific cyclin-E1is aproteinthat in humans is encoded by theCCNE1gene.

Function

The protein encoded by this gene belongs to thehighly conservedcyclin family,whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators ofCDK.Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of eachmitoticevent. This cyclin forms a complex with and functions as a regulatory subunit ofCDK2,whose activity is required for cell cycleG1/S transition.This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute totumorigenesis.This protein was found to associate with, and be involved in, the phosphorylation ofNPATprotein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available.

Interactions

Cyclin E1 has been shown tointeractwith:

• CDC25A,
• CDKN1B,
• CUL3
• Cdk1,
• Cyclin-dependent kinase 2,
• HERC5,
• P21,
• Retinoblastoma-like protein 2,and
• SMARCA4.

See also

• Cyclin E
• Cyclin E/Cdk2

Further reading

• Akita H (2003). "[Prognostic importance of altered expression of cell cycle regulators in lung cancer]".Nippon Rinsho.60. Suppl 5: 267–71.PMID12101670.
• Mazumder S, DuPree EL, Almasan A (2004)."A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy".Current Cancer Drug Targets.4(1): 65–75.doi:10.2174/1568009043481669.PMC1307511.PMID14965268.
• Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA (1992). "Regulation of retinoblastoma protein functions by ectopic expression of human cyclins".Cell.70(6): 993–1006.doi:10.1016/0092-8674(92)90249-C.PMID1388095.S2CID30799229.
• Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM (1992). "Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle".Science.257(5077): 1689–94.Bibcode:1992Sci...257.1689K.doi:10.1126/science.1388288.PMID1388288.
• Koff A, Cross F, Fisher A, Schumacher J, Leguellec K, Philippe M, Roberts JM (1991). "Human cyclin E, a new cyclin that interacts with two members of the CDC2 gene family".Cell.66(6): 1217–28.doi:10.1016/0092-8674(91)90044-Y.PMID1833068.S2CID38910227.
• Demetrick DJ, Matsumoto S, Hannon GJ, Okamoto K, Xiong Y, Zhang H, Beach DH (1995). "Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3)".Cytogenet. Cell Genet.69(3–4): 190–2.doi:10.1159/000133960.PMID7698009.
• Ohtsubo M, Theodoras AM, Schumacher J, Roberts JM, Pagano M (1995)."Human cyclin E, a nuclear protein essential for the G1-to-S phase transition".Mol. Cell. Biol.15(5): 2612–24.doi:10.1128/mcb.15.5.2612.PMC230491.PMID7739542.
• Sewing A, Rönicke V, Bürger C, Funk M, Müller R (1994). "Alternative splicing of human cyclin E.".J. Cell Sci.107. ( Pt 2) (2): 581–8.doi:10.1242/jcs.107.2.581.PMID8207080.
• Dyson N, Dembski M, Fattaey A, Ngwu C, Ewen M, Helin K (1993)."Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1".J. Virol.67(12): 7641–7.doi:10.1128/JVI.67.12.7641-7647.1993.PMC238233.PMID8230483.
• Li Y, Graham C, Lacy S, Duncan AM, Whyte P (1994)."The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E."Genes Dev.7(12A): 2366–77.doi:10.1101/gad.7.12a.2366.PMID8253383.
• Xu X, Burke SP (1996)."Roles of active site residues and the NH2-terminal domain in the catalysis and substrate binding of human Cdc25".J. Biol. Chem.271(9): 5118–24.doi:10.1074/jbc.271.9.5118.PMID8617791.
• Ohtani K, DeGregori J, Nevins JR (1996)."Regulation of the cyclin E gene by transcription factor E2F1".Proc. Natl. Acad. Sci. U.S.A.92(26): 12146–50.doi:10.1073/pnas.92.26.12146.PMC40313.PMID8618861.
• Geng Y, Eaton EN, Picón M, Roberts JM, Lundberg AS, Gifford A, Sardet C, Weinberg RA (1996). "Regulation of cyclin E transcription by E2Fs and retinoblastoma protein".Oncogene.12(6): 1173–80.PMID8649818.
• Poon RY, Jiang W, Toyoshima H, Hunter T (1996)."Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage".J. Biol. Chem.271(22): 13283–91.doi:10.1074/jbc.271.22.13283.PMID8662825.
• Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A (1996)."Cyclin-binding motifs are essential for the function of p21CIP1".Mol. Cell. Biol.16(9): 4673–82.doi:10.1128/MCB.16.9.4673.PMC231467.PMID8756624.
• Li H, Lahti JM, Valentine M, Saito M, Reed SI, Look AT, Kidd VJ (1997). "Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors".Genomics.32(2): 253–9.doi:10.1006/geno.1996.0112.PMID8833152.
• Won KA, Reed SI (1996)."Activation of cyclin E/CDK2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E."EMBO J.15(16): 4182–93.doi:10.1002/j.1460-2075.1996.tb00793.x.PMC452142.PMID8861947.
• Sala A, Kundu M, Casella I, Engelhard A, Calabretta B, Grasso L, Paggi MG, Giordano A, Watson RJ, Khalili K, Peschle C (1997)."Activation of human B-MYB by cyclins".Proc. Natl. Acad. Sci. U.S.A.94(2): 532–6.Bibcode:1997PNAS...94..532S.doi:10.1073/pnas.94.2.532.PMC19547.PMID9012818.
• Mumberg D, Wick M, Bürger C, Haas K, Funk M, Müller R (1997)."Cyclin ET, a new splice variant of human cyclin E with a unique expression pattern during cell cycle progression and differentiation".Nucleic Acids Res.25(11): 2098–105.doi:10.1093/nar/25.11.2098.PMC146711.PMID9153308.