Cytochrome P450 eryF
| Cytochrome P450 eryF | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | eryF | ||||||
| Alt. symbols | CYP107A1 | ||||||
| UniProt | Q00441 | ||||||
| Other data | |||||||
| EC number | 1.14.15.35 | ||||||
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6-deoxyerythronolide B hydroxylaseis anActinomycetotaCytochrome P450enzymeoriginally fromSaccharopolyspora erythraea,catalyzes the 6S-hydroxylate of6-deoxyerythronolide B(6-DEB) toerythronolide B(EB) which is the first step of biosynthesis of themacrolideantibioticerythromycin.[1][2]This bacterial enzyme belongs to CYP familyCYP107,with the CYP SymbolCYP107A1.[3][4]
References
[edit]- ^Weber JM, Leung JO, Swanson SJ, Idler KB, McAlpine JB (April 1991). "An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea".Science.252(5002): 114–7.Bibcode:1991Sci...252..114W.doi:10.1126/science.2011746.PMID2011746.
- ^Andersen JF, Hutchinson CR (February 1992)."Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase".Journal of Bacteriology.174(3): 725–35.doi:10.1128/jb.174.3.725-735.1992.PMC206148.PMID1732208.
- ^Cupp-Vickery JR, Poulos TL (February 1995). "Structure of cytochrome P450eryF involved in erythromycin biosynthesis".Nature Structural Biology.2(2): 144–53.doi:10.1038/nsb0295-144.PMID7749919.S2CID22536232.
- ^Harris DL (September 2002). "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF".Journal of Inorganic Biochemistry.91(4): 568–85.doi:10.1016/s0162-0134(02)00477-4.PMID12237223.
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