DCTN5

DCTN5
Identifiers
Aliases	DCTN5,dynactin subunit 5
External IDs	OMIM:612962;MGI:1891689;HomoloGene:10998;GeneCards:DCTN5;OMA:DCTN5 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	23,677,472bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	121,748,267bp
RNA expressionpattern
	Top expressed in
	islet of Langerhans; ; rectum; ; stromal cell of endometrium; ; smooth muscle tissue; ; monocyte; ; mucosa of esophagus; ; ganglionic eminence; ; lymph node; ; epithelium of colon; ; mucosa of transverse colon;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; right kidney; ; granulocyte; ; superior frontal gyrus; ; medial ganglionic eminence; ; yolk sac; ; pituitary gland; ; tail of embryo; ; cumulus cell; ; blood;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytosol; centrosome; nuclear membrane; chromosome, centromeric region; cytoskeleton; kinetochore; nucleoplasm; chromosome;
Biological process	endoplasmic reticulum to Golgi vesicle-mediated transport; aorta development; ventricular septum development; antigen processing and presentation of exogenous peptide antigen via MHC class II; coronary vasculature development;
	Sources:Amigo/QuickGO
Orthologs
	84516
	59288
	ENSG00000166847
	ENSMUSG00000030868
	Q9BTE1
	Q9QZB9
	NM_001199011; NM_001199743; NM_032486
	NM_021608
	NP_001185940; NP_001186672; NP_115875
	NP_067621
	Wikidata
View/Edit Human	View/Edit Mouse

Dynactin 5 (p25)is aproteinthat in humans is encoded by the DCTN5gene.^[5]

This gene encodes a subunit of dynactin, a component of the cytoplasmic dynein motor machinery involved in minus-end-directed transport. The encoded protein is a component of the pointed-end subcomplex and is thought to bind membranous cargo. A pseudogene of this gene is located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.^[5]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000166847–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000030868–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^^a ^b"Entrez Gene: Dynactin 5 (p25)".Retrieved2011-09-20.

Eckley DM, Gill SR, Melkonian KA, Bingham JB, Goodson HV, Heuser JE, et al. (October 1999)."Analysis of dynactin subcomplexes reveals a novel actin-related protein associated with the arp1 minifilament pointed end".The Journal of Cell Biology.147(2): 307–320.doi:10.1083/jcb.147.2.307.PMC2174220.PMID 10525537. Parisi G, Fornasari MS, Echave J (March 2004). "Dynactins p25 and p27 are predicted to adopt the LbetaH fold".FEBS Letters.562(1–3): 1–4.doi:10.1016/S0014-5793(04)00165-6.PMID 15043994.S2CID 84381211. Burton PR, Clayton DG, Cardon LR, Craddock N, Deloukas P, Duncanson A, et al. (June 2007)."Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls".Nature.447(7145): 661–678.Bibcode:2007Natur.447..661B.doi:10.1038/nature05911.PMC2719288.PMID 17554300.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000166847–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030868–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dynactin 5 (p25)".Retrieved2011-09-20.

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References

Further reading