Dectaflur
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| Routes of administration | Topical(gel, solution) |
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| ECHA InfoCard | 100.297.781 |
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| Formula | C18H38FN |
| Molar mass | 287.507g·mol−1 |
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Dectaflur(INN) is afluoride-containing substance used for the prevention and treatment ofdental caries,sensitiveteeth,and the refluoridation of damagedtooth enamel,typically in combination witholaflur.[1]
Chemistry and mechanism of action
[edit]Dectaflur consists ofoleyl amine(the amine corresponding tooleyl alcohol) andhydrofluoric acid.Oleyl amine with its longlipophilichydrocarbonchain hassurfactantproperties. It forms a film layer on the surface of teeth, which facilitates incorporation of fluoride into the top layers of the enamel, reaching a depth of only a fewnanometers.The precise mechanism of action is unknown.[2]
Side effects
[edit]Like other fluorides, dectaflur is toxic when overdosed over an extended period of time. Especially in children, before the development of thepermanent teeth,overdosage can lead todental fluorosis.[3]
References
[edit]- ^Haberfeld H, ed. (2009).Austria-Codex(in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Elmex Zahngel.ISBN978-3-85200-196-8.
- ^Müller F, Zeitz C, Mantz H, Ehses KH, Soldera F, Schmauch J, et al. (December 2010). "Elemental depth profiling of fluoridated hydroxyapatite: saving your dentition by the skin of your teeth?".Langmuir.26(24): 18750–9.doi:10.1021/la102325e.PMID21090577.
- ^Abanto Alvarez J, Rezende KM, Marocho SM, Alves FB, Celiberti P, Ciamponi AL (February 2009). "Dental fluorosis: exposure, prevention and management".Medicina Oral, Patologia Oral y Cirugia Bucal.14(2): E103-7.PMID19179949.