Dysmetria
| Dysmetria | |
|---|---|
| Specialty | Neurology |
Dysmetria(English:wrong length) is a lack of coordination of movement typified by the undershoot or overshoot of intended position with the hand, arm, leg, or eye. It is a type ofataxia.It can also include an inability to judge distance or scale.[1]
Hypermetriaandhypometriaare, respectively, overshooting and undershooting the intended position.[2][3]
Presentation
[edit]Associated diseases
[edit]Dysmetria is often found in individuals withmultiple sclerosis(MS),amyotrophic lateral sclerosis(ALS), and persons who have hadtumorsorstrokes.Persons who have been diagnosed withautosomaldominantspinocerebellar ataxia(SCAs) also exhibit dysmetria.[4]There are many types of SCAs and though many exhibit similar symptoms (one being dysmetria), they are considered to be heterogeneous.[4]Friedreich's ataxiais a relatively common cause of dysmetria.[5]Cerebellar malformations extending to thebrainstemcan also present with dysmetria.[6]
Causes
[edit]The actual cause of dysmetria is thought to be caused by lesions in the cerebellum or by lesions in the proprioceptive nerves that lead to the cerebellum that coordinate visual, spatial and other sensory information with motor control.[7]Damage to theproprioceptivenerves does not allow the cerebellum to accurately judge where the hand, arm, leg, or eye should move. These lesions are often caused bystrokes,multiple sclerosis(MS),amyotrophic lateral sclerosis(ALS), ortumors.[citation needed]
According to the research article cited above, motor control is a learning process that utilizes APPGs.[8]Disruption of APPGs is possibly the cause of ataxia and dysmetria and upon identification of the motor primitives, clinicians may be able to isolate the specific areas responsible for the cerebellar problems.[8]
There are two types of cerebellar disorders that produce dysmetria, specifically midline cerebellar syndromes and hemispheric cerebellar syndromes. Midline cerebellar syndromes can causeocular dysmetria,a condition in which the eyes can not track an object properly and either overshoot (ahead of the object )or undershoot (lagging behind the object). Ocular dysmetria also makes it difficult to maintain fixation on a stationary object. Hemispheric cerebellar syndromes cause dysmetria in the typical motor sense that many think of when hearing the term dysmetria.[citation needed]
A common motor syndrome that causes dysmetria is cerebellar motor syndrome, which also marked by impairments ingait(also known asataxia), disordered eye movements,tremor,difficultyswallowingand poorarticulation.[5]As stated above, cerebellar cognitive affective syndrome (CCAS) also causes dysmetria.
Anatomy
[edit]Thecerebellumis the area of the brain that contributes to coordination and motor processes and is anatomically inferior to thecerebrum.[9][7]Sensorimotorintegration is the brain's way of integrating the information received from thesensory (or proprioceptive) neuronsfrom the body, including any visual information. To be more specific, information needed to perform a motor task comes fromretinalinformation pertaining to the eyes' position and has to be translated into spatial information. Sensorimotor integration is crucial for performing any motor task and takes place in the post parietal cortex.[9][10]After the visual information has been translated into spatial information, the cerebellum must use this information to perform the motor task.[5]If there is damage to any pathways that connect the pathways, dysmetria may result.[citation needed]
Motor
[edit]Motor dysmetria is the customary term used when a person refers to dysmetria. Dysmetria of the extremities caused by hemispheric syndromes is manifested in multiple ways:dysrhythmictapping of hands and feet anddysdiadochokinesis,which is the impairment of alternating movements.[5]Damage to the cerebellum makes a person slow to orient their extremities in space.[7]
Motor control as a learning process
Recent research has also shed light upon a specific process that if interrupted, may be the cause ofataxiaand dysmetria. According to sources cited in this article,motor controlis a learning process that occurs in thesynapsesofPurkinjedendrites.[8]There have been varying theories as to the makeup of the cerebellum, which controls this process. Some predicted that the cerebellum was an array of adjustable pattern generators (APGs), each of which generate a "burst command" with varying intensity and duration. Other models, which apply mostly inroboticapplications, propose that the cerebellum acquires an "inverse model of the motor apparatus".[8]More recent research inelectrophysiologyhas shown modular structures in thespinal cordknown as "motor primitives".[8] Based on the APG model, modules of APG are the features that controlmotor learning.[8]The entire process is apositive feedback loop.Inhibitory input is transmitted and received from various components of thecortex,including thecerebellar nucleus,a motor cortical cell andPurkinje cells.[8]Purkinje cells send the inhibitive information by obtaining learning information from parallel fibers ofgranule cells.This model of APGs is useful in that it effectively describes the motor learning process.[8]
Motor primitives are another proposed module of motor learning.[8]This information was found by electrical stimulation of thelumbar spinal cordin rats and frogs.[8]Upon the stimulation, researchers found that motor primitives are found in thespinal cordand use patterns ofmuscleactivation to generate a specific motor output. Different movements are learned from different levels of activation. These findings led researchers to believe that these same motor primitives could be found in the cerebellum.[8]
These two different models combined show that it is possible that motor primitives are in the cerebellum, because, "a set of parallel arrays of APG can drive each motor primitive module in the spinal cord."[8]The authors have generated a model of adjustable primitive pattern generator (APPG), which is basically a group of parallel APGs summed together.[8]
The APPG model is a vector sum of all the inputs of the APG, which are units of position, velocity and time.[8]Granule cellssend information from the spinal cord and themotor cortexwhich in turn translates the information in a process called state mapping.[8]The final model of the APPG becomes linear upon the vector summation of the information from theneuronsand muscles.[8]This model is consistent with the "virtual trajectory hypothesis" which states that the desired trajectory is sent to the spinal cord as a motor command.[8]
Saccadic
[edit]Saccadesare the very quick, simultaneous movements made by the eye to receive visual information and shift the line of vision from one position to another.[11]A person depends profoundly on the ability of the accuracy of these movements.[11]The information is received from the retina, is translated into spatial information and is then transferred to motor centers for motor response. A person with saccadic dysmetria will constantly produce abnormal eye movements including microsaccades, ocular flutter, and square wave jerks even when the eye is at rest.[5]During eye movements hypometric andhypermetricsaccades will occur and interruption and slowing of normal saccadic movement is common.[5]
Diagnosis
[edit]Diagnosis of any cerebellar disorder or syndrome should be made by a qualifiedneurologist.Prior to referring a patient to a neurologist, a general practitioner or MS nurse will perform a finger-to-nose test.[5]The clinician will raise a finger in front of the patient and ask him to touch it with his finger and then touch his nose with his forefinger several times. This shows a patient's ability to judge the position of a target. Other tests that could be performed are similar in nature and include a heel to shin test in whichproximalovershoot characterizes dysmetria and an inability to draw an imaginary circle with the arms or legs without any decomposition of movement.[5]After a positive result in the finger-to-nose test, a neurologist will do amagnetic resonance image(MRI) to determine any damage to the cerebellum.[5]
Cerebellar patients encounter difficulties to adapt to unexpected changes of the inertia of the limbs.[12]This can be used to increase dysmetria and confirm a diagnosis of cerebellar dysfunction. Patients also show an abnormal response to changes in damping. These findings confirm a role of the cerebellum in predictions.[13]
Treatments
[edit]Currently there is no cure for dysmetria itself as it is actually a symptom of an underlying disorder. However,isoniazidandclonazepamhave been used to treat dysmetria.Frenkel exercisestreat dysmetria.[citation needed]
Research
[edit]Researchers now are testing different possibilities for treating dysmetria andataxia.One opportunity for treatment is called rehearsal by eye movement.[14]It is believed that visually guided movements require both lower- and higher-order visual functioning by first identifying a target location and then moving to acquire what is sought after.[4]In one study, researchers used visually guided stepping which is parallel to visually guided arm movements to test this treatment.[14]The patients had saccadic dysmetria which in turn caused them to overshoot their movements 3. The patients first walked normally and were then told to twice review the area that was to be walked through 3. After rehearsal with eye movements, the patients improved their motor performance.[14]Researchers believe that prior rehearsal with the eyes might be enough for a patient with motor dysmetria as a result of saccadic dysmetria to complete a motor task with enhancedspatial awareness.[14]
Research has also been done for those patients with MS.[15]Deep brain stimulation (DBS) remains a viable possibility for some MS patients though the long-term effects of this treatment are currently under review.[15]The subjects who have undergone this treatment had no major relapse for six months and disabling motor function problems.[15]Most subjects benefited from the implantation of theelectrodesand some reported that their movement disorder was gone after surgery.[15]However, these results are limiting at this time because of the small range of subjects who were used for the experiment and it is unknown whether this is a viable option for all MS patients with motor control problems.[15]
See also
[edit]References
[edit]- ^"dysmetria – definition of dysmetria in the Medical dictionary – by the Free Online Medical Dictionary, Thesaurus and Encyclopedia".
- ^Schmahmann JD, Weilburg JB, Sherman JC (2007). "The neuropsychiatry of the cerebellum – insights from the clinic".Cerebellum.6(3): 254–67.doi:10.1080/14734220701490995.PMID17786822.S2CID14176315.
- ^Manto M (2009)."Mechanisms of human cerebellar dysmetria: experimental evidence and current conceptual bases".J Neuroeng Rehabil.6:10.doi:10.1186/1743-0003-6-10.PMC2679756.PMID19364396.
- ^abcManto MU (2005). "The wide spectrum of spinocerebellar ataxias (SCAs)".Cerebellum.4(1): 2–6.doi:10.1080/14734220510007914.PMID15895552.S2CID5311177.
- ^abcdefghiSchmahmann JD (2004). "Disorders of the cerebellum: ataxia, dysmetria of thought, and the cerebellar cognitive affective syndrome".J Neuropsychiatry Clin Neurosci.16(3): 367–78.doi:10.1176/jnp.16.3.367.PMID15377747.
- ^Mario Manto (2010).Cerebellar Disorders: A Practical Approach to Diagnosis and Management.Cambridge, UK: Cambridge University Press.ISBN978-0-521-87813-5.OCLC456170457.
- ^abcTownsend J, Courchesne E, Covington J, et al. (July 1999)."Spatial attention deficits in patients with acquired or developmental cerebellar abnormality".J. Neurosci.19(13): 5632–43.doi:10.1523/JNEUROSCI.19-13-05632.1999.PMC6782343.PMID10377369.
- ^abcdefghijklmnopqVahdat S, Maghsoudi A, Haji Hasani M, Towhidkhah F, Gharibzadeh S, Jahed M (October 2006). "Adjustable primitive pattern generator: a novel cerebellar model for reaching movements".Neurosci. Lett.406(3): 232–4.doi:10.1016/j.neulet.2006.07.038.PMID16930835.S2CID9679947.
- ^abTrillenberg P, Sprenger A, Petersen D, Kömpf D, Heide W, Helmchen C (2007). "Functional dissociation of saccade and hand reaching control with bilateral lesions of the medial wall of the intraparietal sulcus: implications for optic ataxia".NeuroImage.36(Suppl 2): T69–76.doi:10.1016/j.neuroimage.2007.03.038.PMID17499172.S2CID43241167.
- ^Indovina I, Sanes JN (October 2001). "Combined visual attention and finger movement effects on human brain representations".Exp Brain Res.140(3): 265–79.doi:10.1007/s002210100796.PMID11681302.S2CID14364368.
- ^abIwamoto Y, Yoshida K (June 2002). "Saccadic dysmetria following inactivation of the primate fastigial oculomotor region".Neurosci. Lett.325(3): 211–5.doi:10.1016/S0304-3940(02)00268-9.PMID12044658.S2CID35443728.
- ^Manto, M.; Godaux, E.; Jacquy, J. (January 1994). "Cerebellar hypermetria is larger when the inertial load is artificially increased".Annals of Neurology.35(1): 45–52.doi:10.1002/ana.410350108.ISSN0364-5134.PMID8285591.S2CID19328973.
- ^Leggio, M.; Molinari, M. (February 2015). "Cerebellar sequencing: a trick for predicting the future".Cerebellum (London, England).14(1): 35–38.doi:10.1007/s12311-014-0616-x.ISSN1473-4230.PMID25331541.S2CID15713873.
- ^abcdCrowdy KA, Kaur-Mann D, Cooper HL, Mansfield AG, Offord JL, Marple-Horvat DE (September 2002). "Rehearsal by eye movement improves visuomotor performance in cerebellar patients".Exp Brain Res.146(2): 244–7.doi:10.1007/s00221-002-1171-0.PMID12195526.S2CID7703727.
- ^abcdeHooper J, Taylor R, Pentland B, Whittle IR (April 2002). "A prospective study of thalamic deep brain stimulation for the treatment of movement disorders in multiple sclerosis".Br J Neurosurg.16(2): 102–9.doi:10.1080/02688690220131769.PMID12046727.S2CID30644098.