EAF1

EAF1
Identifiers
Aliases	EAF1,ELL associated factor 1
External IDs	OMIM:608315;MGI:1921677;HomoloGene:12561;GeneCards:EAF1;OMA:EAF1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	15,450,635bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	31,231,815bp
RNA expressionpattern
	Top expressed in
	amniotic fluid; ; islet of Langerhans; ; decidua; ; monocyte; ; secondary oocyte; ; lower lobe of lung; ; palpebral conjunctiva; ; pancreatic epithelial cell; ; epithelium of nasopharynx; ; prefrontal cortex;
	Top expressed in
	epithelium of lens; ; tail of embryo; ; olfactory epithelium; ; decidua; ; primitive streak; ; superior cervical ganglion; ; gastrula; ; thymus; ; genital tubercle; ; endothelial cell of lymphatic vessel;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	Cajal body; nuclear speck; transcription elongation factor complex; super elongation complex; intracellular membrane-bounded organelle; intercellular bridge; nucleus; nucleoplasm; nuclear body;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter;
	Sources:Amigo/QuickGO
Orthologs
	85403
	74427
	ENSG00000144597
	ENSMUSG00000021890
	Q96JC9
	Q9D4C5
	NM_033083
	NM_028932
	NP_149074
	NP_083208
	Wikidata
View/Edit Human	View/Edit Mouse

ELL-associated factor 1is aproteinthat, in humans, is encoded by theEAF1gene.^[5]^[6]It is part of theEAF familyof proteins.

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000144597–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000021890–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Simone F, Polak PE, Kaberlein JJ, Luo RT, Levitan DA, Thirman MJ (July 2001). "EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein".Blood.98(1): 201–9.doi:10.1182/blood.V98.1.201.PMID 11418481.S2CID 2577367.
^"Entrez Gene: EAF1 ELL associated factor 1".

Polak PE, Simone F, Kaberlein JJ, Luo RT, Thirman MJ (April 2003)."ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia".Molecular Biology of the Cell.14(4): 1517–28.doi:10.1091/mbc.E02-07-0394.PMC153119.PMID 12686606.
Kong SE, Banks CA, Shilatifard A, Conaway JW, Conaway RC (July 2005)."ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL".Proceedings of the National Academy of Sciences of the United States of America.102(29): 10094–8.Bibcode:2005PNAS..10210094K.doi:10.1073/pnas.0503017102.PMC1177379.PMID 16006523.
Xiao W, Jiang F, Wang Z (January 2006). "ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation".The Prostate.66(1): 1–12.doi:10.1002/pros.20309.PMID 16114057.S2CID 32749490.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.
Jiang F, Ai J, Xiao W, Wang Z (August 2007)."FB1, an E2A fusion partner in childhood leukemia, interacts with U19/EAF2 and inhibits its transcriptional activity".Cancer Letters.253(2): 265–72.doi:10.1016/j.canlet.2007.02.003.PMC1989770.PMID 17395368.

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